DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3529 and Tom1l1

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001344472.1	Gene:	Tom1l1 / 71943	MGIID:	1919193	Length:	474	Species:	Mus musculus

Alignment Length:	471	Identity:	140/471 - (29%)
Similarity:	240/471 - (50%)	Gaps:	70/471 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FSTPVGQRIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYTL 78
            ::|.||..||.||.|.:.:|:|...:.|||:||.:.|..:||::|::||:|:|  .|::.:..:|
Mouse    11 YATSVGHLIEKATFAGVLTEDWGQFLHICDIINTTQDGPKDAVKALKKRISKN--YNHKEIQLSL 73

  Fly    79 TVLETCVKNCGKAFHVLVAQKDFINE-LVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQPDLNG 142
            ::::.||:|||.:|..|:.:|:||.: ||||:.|:...|...|.::|:.|:.|:..|....|::.
Mouse    74 SLIDMCVQNCGPSFQSLIVKKEFIKDTLVKLLNPRYTLPLETQNRILNFIKTWSQGFPGGVDVSE 138

  Fly   143 VTQMYMELKNKGIEFPANDLDAMAPIYTPQRSVPEMPPQLVAAQQHTISPQH-MAAAAAAAAAAA 206
            |.::|::|..||::||.:|            ..||...:  |.|   |||.. .:...|.|.::.
Mouse   139 VKEVYLDLLKKGVQFPPSD------------GEPETRQE--AGQ---ISPNRPTSVPTAPALSSI 186

  Fly   207 APPSTGPLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPDDYALLNELTSTCKEMQSR 271
            ..|....:.|.|||..||.|||::|..|:.:::.:|....||.|:.:|..||.:|..|.:|||.|
Mouse   187 IAPKNPTISLVPEQIGKLHSELDMVKMNVKVMTAILMENTPGSENHEDIELLRKLYKTGREMQER 251

  Fly   272 IVDLIGRVQDDELTAEFLRINDELNNVFLRHQRYEKN--------RSQGQGAGVTS-PSAVLGAA 327
            |:||:..|:::::|.|.:::|::|||..|.::|:.:|        |::.:....:| |||.....
Mouse   252 IMDLLVVVENEDVTMELIQVNEDLNNAVLGYERFTRNQQRLLEQKRNRTEATRTSSEPSAPSCDL 316

  Fly   328 MGL--------PGVGA-----AGAGATTVATLPPPPTTTAV-SNTPQSDQLLIDLIESSEEAQLP 378
            :.|        |..||     |.....:|::|.|..|.... |..||.|.|      :||:.::|
Mouse   317 LDLSPIVPVPTPNEGALNSVNAQLSGLSVSSLSPVITNNLYPSLQPQRDLL------ASEDIEIP 375

  Fly   379 QSLGQISLGGGAPIGVQRSARPADEFDMLAQSRTDGNHKSD--LLRDIPSVDAAAGSVTATASPY 441
                        .:..||:::      .||.|.|..|..|:  ||:.:....|.|.:......|.
Mouse   376 ------------TLFPQRTSQ------NLASSHTYDNFHSNSVLLQPVSLHTATAAAAANQRLPP 422

  Fly   442 KPNQPQQAQRSAGEPP 457
            .|:.....:....:||
Mouse   423 LPSSHPVLKDGDLQPP 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	51/141 (36%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	32/84 (38%)
Tom1l1	NP_001344472.1	VHS_ENTH_ANTH	14..154	CDD:321980	51/141 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..180		10/43 (23%)
		GAT_TM1L1	198..289	CDD:260095	35/90 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..317		5/25 (20%)
		Interaction with GRB2	392..395		0/2 (0%)
		SH3-binding	420..424		1/3 (33%)
		Interaction with PIK3R1	441..444
		SH2-binding	457..460
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831178
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352228at33208
OrthoFinder	1	1.000	-	-		FOG0000599
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13856
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X466
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850