DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3529 and WDFY1

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_065881.1	Gene:	WDFY1 / 57590	HGNCID:	20451	Length:	410	Species:	Homo sapiens

Alignment Length:	144	Identity:	32/144 - (22%)
Similarity:	52/144 - (36%)	Gaps:	41/144 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 PQRSVPEMPPQLVAAQQHTISPQHMAAAAAAAAAAAAPPSTGPLHLTPEQAAKLRSELEIVSNNM 235
            ||.|.|.:..::...|.            |..||...|...|.  :|..:...:|..|:..|
Human     9 PQSSRPVLLSKIEGHQD------------AVTAALLIPKEDGV--ITASEDRTIRVWLKRDS--- 56

  Fly   236 SILSEMLSVLKPGQESPDDYALLNELTSTCKEM----QSRIVDLIGRVQDDELTAEFLRINDELN 296
                        ||..|..|   :.:.|.|..|    .||.: .:|  ||:....|| .::::.|
Human    57 ------------GQYWPSIY---HTMASPCSAMAYHHDSRRI-FVG--QDNGAVMEF-HVSEDFN 102

  Fly   297 NV-FLRHQRYEKNR 309
            .: |::.....:||
Human   103 KMNFIKTYPAHQNR 116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	19/89 (21%)
WDFY1	NP_065881.1	WD40	16..272	CDD:330360	28/137 (20%)
		WD 1	22..61		12/67 (18%)
		WD40 repeat	28..67	CDD:293791	12/58 (21%)
		WD 2	66..105		11/42 (26%)
		WD40 repeat	71..111	CDD:293791	11/43 (26%)
		WD 3	112..150		2/5 (40%)
		WD40 repeat	117..154	CDD:293791	32/144 (22%)
		WD 4	153..192
		WD40 repeat	159..197	CDD:293791
		WD 5	197..236
		WD40 repeat	202..239	CDD:293791
		WD 6	240..279
		WD40 repeat	246..314	CDD:293791
		FYVE_WDFY1	279..354	CDD:277295
		WD40 repeat	321..363	CDD:293791
		WD 7	364..403
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141236
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930