DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3529 and tom1l2

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_009304960.1	Gene:	tom1l2 / 560327	ZFINID:	ZDB-GENE-061013-3	Length:	527	Species:	Danio rerio

Alignment Length:	559	Identity:	241/559 - (43%)
Similarity:	326/559 - (58%)	Gaps:	66/559 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGNVFSTPVGQRIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVV 74
            |||.:|||||..||.|||.:|.||:|..||||||:|||:.|..:|||||::|||  |..||.:.|
Zfish     5 LGNPYSTPVGHCIERATDGSLQSEDWTLNMEICDIINETEDGPKDAMRAVKKRL--NGNKNYREV 67

  Fly    75 MYTLTVLETCVKNCGKAFHVLVAQKDFIN-ELVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQP 138
            |.|||||||||||||..||:||..:|||: .|||:|.|||:|||.:|:|||:|||.|||||::.|
Zfish    68 MLTLTVLETCVKNCGYRFHMLVTTRDFIDGVLVKIISPKNNPPAIVQDKVLALIQAWADAFRSSP 132

  Fly   139 DLNGVTQMYMELKNKGIEFPANDLDAMAPIYTPQR--SVPEMPPQLVAAQQHTISPQHMAAAA-- 199
            ||.||..:|.|:|.||||||.::|:.::||:||||  :.|||..|..:|........|.|:|.
Zfish   133 DLTGVVHVYEEMKRKGIEFPRSELETLSPIHTPQRQQTAPEMDQQKYSAPVQPKPQPHPASAPPF 197

  Fly   200 AAAAAAAAP--PS---TGPLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPDDYALLN 259
            .|..|..:|  |:   .||::.:|||..||||||:||..|..::||||:.:.||||.|.|:.||.
Zfish   198 TAPVAHTSPQMPNLHIAGPINPSPEQICKLRSELDIVRGNTKVMSEMLTEMVPGQEDPSDHELLQ 262

  Fly   260 ELTSTCKEMQSRIVDLIGRVQDDELTAEFLRINDELNNVFLRHQRYEKNRS----QGQGAGV--- 317
            ||..||:.||.|||:||.||.::|:|.|.|.:||:|||:|||::|||:.||    ||...|:
Zfish   263 ELNRTCRAMQQRIVELISRVSNEEVTEELLHVNDDLNNIFLRYERYERFRSGRTAQGVNNGLREV 327

  Fly   318 ---TSPSAVLGAAMGLPGVGAAGAGATTVATLPPPPTTTAVSNTPQSDQLLIDLIESSEEAQLPQ 379
               .:...::....|.|.|.:....||..::|||       |..|         :.|:....|..
Zfish   328 LNEATEDNLIDLGPGSPAVVSPRISATPPSSLPP-------SVAP---------VRSASPVTLSS 376

  Fly   380 SLGQISLGGGAPIGVQRS---ARPADEFDMLAQSRTDGNHKSDLLRDIPSVDAAAGSVTATASPY 441
            .|..:.:|..:..|...|   .:|.|:|||.||:||.         .:|...:|....|..:|..
Zfish   377 RLAGLDVGSDSVSGTLSSLATCQPQDDFDMFAQTRTG---------TVPEWKSAPFEDTKASSGV 432

  Fly   442 KPNQPQQAQRSAGEPPVVSKSTKENEIDEMEAWLGSSHI---EGIEELTSSEFDKFLEERAAAAE 503
            .|....:.|.:      .:...:.:.:|::|.|| |:.:   ||.|.:||.||||||||||.|||
Zfish   433 APTLDVRQQNA------TAALDQSSVMDDIEEWL-STDVKGDEGEEGVTSEEFDKFLEERAKAAE 490

  Fly   504 NLPTI-SASNSAASATTGSAGADSLRKTPKKPGAEEDLL 541
            .:||: :......||..||:...|     ||.|..||.|
Zfish   491 MVPTLPTPPTDELSAAAGSSANAS-----KKTGRSEDTL 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	89/141 (63%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	48/84 (57%)
tom1l2	XP_009304960.1	VHS_Tom1	12..152	CDD:239623	89/141 (63%)
tom1l2	XP_009304960.1	GAT_TM1L2	221..312	CDD:260096	52/90 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	179	1.000	Domainoid score	I3490
eggNOG	1	0.900	-	-		E1_KOG1087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1981
OMA	1	1.010	-	-		QHG46484
OrthoDB	1	1.010	-	-		D1213216at2759
OrthoFinder	1	1.000	-	-		FOG0000599
OrthoInspector	1	1.000	-	-		otm25424
orthoMCL	1	0.900	-	-		OOG6_102984
Panther	1	1.100	-	-	O	PTHR13856
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	1	1.000	-	-		X466
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870