DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3529 and tom1

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001338580.1	Gene:	tom1 / 553244	ZFINID:	ZDB-GENE-060721-1	Length:	454	Species:	Danio rerio

Alignment Length:	522	Identity:	182/522 - (34%)
Similarity:	279/522 - (53%)	Gaps:	91/522 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FFNVGALGNVFSTPVGQRIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAG 68
            ||.    ||.|||||||.||.||.::|.||:|..||||||::||:.:..:||:|||:||:..|
Zfish     3 FFT----GNPFSTPVGQLIEHATSSSLPSEDWGLNMEICDLVNEAQEGPKDAVRAIKKRILGN-- 61

  Fly    69 KNNQVVMYTLTVLETCVKNCGKAFHVLVAQKDFI-NELVKLIGPKNDPPAAMQEKVLSLIQIWAD 132
            :|.:.||..|:|||.||||||..|||.|:.:||: |.||:.|.|||:.|..:|::||.:||.|||
Zfish    62 RNFKEVMLALSVLEACVKNCGHKFHVYVSTRDFVENVLVQTILPKNNAPVVLQDRVLIMIQAWAD 126

  Fly   133 AFKNQPDLNGVTQMYMELKNKGIEFPANDLDAMAPIYTPQRSVPEMPPQLVAAQQHTISPQHMAA 197
            ||::..||.||..:|.:|:.:|:|||..:|:..:||:||:|||..:.|.....:.|.::
Zfish   127 AFRSSTDLTGVVTVYEDLRRRGVEFPMTELNGYSPIHTPKRSVENVSPVKAHTESHPVT------ 185

  Fly   198 AAAAAAAAAAPPST-GPLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPDDYALLNEL 261
                   ::.|.:| .|:.|:|:|...:::|||:|.||:|::|:|::.::|....|.|..||.:|
Zfish   186 -------SSQPQNTETPVTLSPKQMKTIKAELEVVRNNLSVMSDMMNQMEPATFEPSDTELLQQL 243

  Fly   262 TSTCKEMQSRIVDLIGRVQDDELTAEFLRINDELNNVFLRHQRYEKNRSQGQGAGVTSPSAVLGA 326
            .|..|:||||:|::|..:.|::||.:.|..||::|..|.::.|:||:.|:...|...:||
Zfish   244 YSMTKDMQSRMVEVIPTLTDEKLTEQLLNANDDINTTFTQYHRFEKHLSRQSSAQPNAPS----- 303

  Fly   327 AMGLPGVGAAGAGATTVATLPPPPTTTAVSNTPQSDQLLIDLIESSEEAQLPQSLGQISLGGGAP 391
                          |.:..|..|....|.:...||....:
Zfish   304 --------------TNLTDLDSPKQLKAANGAHQSAVTTL------------------------- 329

  Fly   392 IGVQRSARPADEFDMLAQSRTDGNHKSDLLRDIPSVDAAAGSVTATASPYKPNQPQQAQ--RSAG 454
                     :::...|:....|.|.||..|...|...|      |.|:|.:.....:::  .|.|
Zfish   330 ---------SNQMSGLSTKEDDLNFKSSSLLKSPERSA------ALATPGRDTGLDESRDSTSLG 379

  Fly   455 EPP----VVSKS---TKENEI-DEMEAWLGSSHIEGIEE-LTSSEFDKFLEERAAAAENLPTISA 510
            ..|    ::.|.   ..::|: |::|.||.....|...| :||.||||||.|||.|||.||::.|
Zfish   380 SSPQFLWMIEKGMIPVNQSEVMDDIEQWLDDVDDEDDSEGVTSEEFDKFLAERAKAAERLPSVKA 444

  Fly   511 SN 512
            |:
Zfish   445 SH 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	73/141 (52%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	32/84 (38%)
tom1	NP_001338580.1	VHS_ENTH_ANTH	12..152	CDD:321980	73/141 (52%)
tom1	NP_001338580.1	GAT_TOM1_like	203..289	CDD:260091	32/85 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574142
Domainoid	1	1.000	179	1.000	Domainoid score	I3490
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1213216at2759
OrthoFinder	1	1.000	-	-		FOG0000599
OrthoInspector	1	1.000	-	-		otm25424
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13856
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X466
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.950