DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3529 and tom1

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001016770.1	Gene:	tom1 / 549524	XenbaseID:	XB-GENE-5834946	Length:	495	Species:	Xenopus tropicalis

Alignment Length:	564	Identity:	226/564 - (40%)
Similarity:	303/564 - (53%)	Gaps:	103/564 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGNVFSTPVGQRIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVV 74
            |||.|:||||||||.|||.:|.||:|..|||:||:|||:.|..:||:||::||:..|  ||.:.|
Frog     5 LGNAFATPVGQRIEKATDGSLRSEDWGLNMEVCDIINETEDGPKDAIRALKKRIVGN--KNFREV 67

  Fly    75 MYTLTVLETCVKNCGKAFHVLVAQKDFI-NELVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQP 138
            |..||:|||||||||..|||||..::|: ..|||.|.|||:|||.:.:|||.|||.|||||::.|
Frog    68 MLALTLLETCVKNCGHRFHVLVGSQEFVEGVLVKTILPKNNPPAIVHDKVLILIQAWADAFRSSP 132

  Fly   139 DLNGVTQMYMELKNKGIEFPANDLDAMAPIYTPQR--SVPEMPPQLVAAQQ---------HTISP 192
            ||.||..:|.:|:.||:|||..|||.::||:|||.  |.||.|.|......         |:..|
Frog   133 DLTGVVSVYEDLRRKGLEFPMTDLDTLSPIHTPQPSFSAPESPSQQDCPSSEFPQRGGSVHSEPP 197

  Fly   193 QHMAAAAAAAAAAAAPPSTGPLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPDDYAL 257
            .:...|.|:...|..|        ||:|.|||.||||||:.|..::||||:.|.|......|..|
Frog   198 PYNVPATASGDTAVTP--------TPDQLAKLHSELEIVNGNAKVMSEMLTELVPQTAKQSDVEL 254

  Fly   258 LNELTSTCKEMQSRIVDLIGRVQDDELTAEFLRINDELNNVFLRHQRYEKNRSQGQGAGVTSPSA 322
            |.||..||:.||.|:::||.||..::||.|.|.:||.|||||:||:|:|:..:..||.
Frog   255 LQELNRTCRAMQQRVLELIPRVTHEQLTEELLIVNDNLNNVFIRHERFERMLAGQQGP------- 312

  Fly   323 VLGAAMGLPGVGAAGAGATTVATLPPPPTTTAVSNTPQSDQLLIDLIE--SSEEAQLPQSLGQIS 385
                        .|.|.......|||.               ||||.|  |:....|...|..|:
Frog   313 ------------VAEAQVARDRVLPPS---------------LIDLEETPSNSAPTLSTQLAGIN 350

  Fly   386 LGGGAPIGVQRS----ARPADEFDMLAQSRTDGNHKSDLLRDI-----PSVDAAAGSVTATASPY 441
            |..|:..|..:|    .:|.|:|||.|.:|  |:..:|..:.:     .:.|..||::
Frog   351 LSSGSVSGTLQSLGGTKKPDDDFDMFALTR--GSSLADQRKSVKYEEPQATDGLAGAL------- 406

  Fly   442 KPNQPQQAQRSAGEPPVVSKSTKENEIDEMEAWLGS---SHIEGIEELTSSEFDKFLEERAAAAE 503
                 ...|::.|..|    :.:.|.:|::|.||.|   ..|||.:.:||.||||||||||.||:
Frog   407 -----DTRQQNTGAIP----AAQNNFMDDIEKWLSSDTGEEIEGEDGVTSEEFDKFLEERAKAAD 462

  Fly   504 NLPTISASNSAASATTGSAGADSLRKTPK----KPGAEEDLLAL 543
            .:|::|           |.|.:..|..|.    |..||:.|.||
Frog   463 RIPSLS-----------SPGTEPPRAAPSTKRDKKEAEDALFAL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	82/141 (58%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	44/84 (52%)
tom1	NP_001016770.1	VHS_Tom1	12..148	CDD:340792	79/137 (58%)
tom1	NP_001016770.1	GAT_TOM1	215..309	CDD:260094	47/93 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3599
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2091
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352228at33208
OrthoFinder	1	1.000	-	-		FOG0000599
OrthoInspector	1	1.000	-	-		otm48230
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X466
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060