DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3529 and gga3a

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001082823.2	Gene:	gga3a / 492643	ZFINID:	ZDB-GENE-041111-218	Length:	699	Species:	Danio rerio

Alignment Length:	545	Identity:	121/545 - (22%)
Similarity:	209/545 - (38%)	Gaps:	130/545 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PVGQRIEA----ATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYT 77
            |.|:.:|:    ||:.:...|.|...:..||.||:..:..:.::|.:..::.   .......:..
Zfish     4 PEGESLESWLNKATNPSNRQEEWEYIIGFCDQINKELEGPQISVRLLAHKIQ---SPQEWESLQA 65

  Fly    78 LTVLETCVKNCGKAFHVLVAQKDFINELVKLIGPK---NDPPAAMQEKVLSLIQIWADAFKNQPD 139
            |||||.|:||||..||..|.:..|:|||:||:.||   :.....::.||:.|:...:.|.   ||
Zfish    66 LTVLEACMKNCGGRFHNEVGKFRFLNELIKLVSPKYLGDRVSERVKTKVIELLYNCSVAL---PD 127

  Fly   140 LNGVTQMYMELKNKGI--EFPANDLDAMAPIYTPQRSVP----EMPPQLVAAQQHTISPQHMAAA 198
            ...:.:.|..||.:||  :.|...:|... |.:|:...|    |...:.:|....:..|:.:..|
Zfish   128 EAKIAEAYHMLKKQGIVTKDPEVHVDRTL-IPSPKTKNPVFDNEEKSKRLAELLKSKKPEDLQEA 191

  Fly   199 AAAAAAAAAPPSTGPLHLTPEQAAKLR------SELEIVSNNMSILSEMLSVLKPGQESPDDYAL 257
            .....           ::..|..|..:      |.||.|:|::.:|:||||..|..:.:.:|..|
Zfish   192 NRIIK-----------NMVKEDEALQQKVSNRVSTLEKVNNSVKLLNEMLSHFKTDESTQEDKEL 245

  Fly   258 LNELTSTCKEMQSRIVDLIGRVQDDE-LTAEFLRINDELNNVFLRHQRYEKNRSQGQGAGVTSPS 321
            |.:|.:.|..:::.:..|....:||: ...:.|..:|:|:.|...:    |...:||
Zfish   246 LKDLYNDCDNLRTAVFRLATETEDDDSALGDILHASDDLSRVINSY----KKIVEGQ-------- 298

  Fly   322 AVLGAAMGLPGVGAAGAGATTVATLPPPPTTTAVSNTPQSDQLLIDLIESSEEAQLPQSLGQISL 386
                                |:....|..|.:...|...|.::||||.:               |
Zfish   299 --------------------TIVIDVPASTPSGCINDRSSSEILIDLAD---------------L 328

  Fly   387 GGGAPIGVQRSARPADEFDMLAQSRTDGNHKSDLLRDIPSVDAAAGSVTATASPYKPNQPQQAQR 451
            |.|.|..::....|....|..|         :|||               |.:.....||..:..
Zfish   329 GSGTPSPLRHGLTPPQHSDSPA---------ADLL---------------TLTSLMGAQPSSSNT 369

  Fly   452 SAG------EPPVVSKSTKENEIDEMEAWLGSSHIEGIEELTSSEFDKFLEERAAAAENLPTISA 510
            |:|      .||   .|...:.:..::..|||..:..::..:.:..:|..:|           :.
Zfish   370 SSGSSSFQTSPP---SSQLPSSLSLLDEELGSFGLGSLDSNSRTSAEKTTKE-----------AQ 420

  Fly   511 SNSAASATTGSAGADSL-RKTPKKP 534
            ||...|:...:...|.| ..||..|
Zfish   421 SNQWISSQISNPVTDFLCSSTPLNP 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	44/149 (30%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	24/91 (26%)
gga3a	NP_001082823.2	VHS_GGA	8..145	CDD:239624	42/142 (30%)
		GAT_SF	212..297	CDD:322464	24/88 (27%)
		Alpha_adaptinC2	577..691	CDD:197886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910