DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3529 and Tom1

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001008366.1	Gene:	Tom1 / 361370	RGDID:	1308024	Length:	492	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	236/549 - (42%)
Similarity:	315/549 - (57%)	Gaps:	81/549 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGNVFSTPVGQRIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVV 74
            |||.||:|||||||.|||.:|.||:||.||||||:|||:.:..:||.||::||:..|  ||...|
  Rat     5 LGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDAFRAVKKRIVGN--KNFHEV 67

  Fly    75 MYTLTVLETCVKNCGKAFHVLVAQKDFI-NELVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQP 138
            |..||||||||||||..||||||.:||: |.||:.|.|||:||..:.:|||:|||.|||||::.|
  Rat    68 MLALTVLETCVKNCGHRFHVLVASQDFVENVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSP 132

  Fly   139 DLNGVTQMYMELKNKGIEFPANDLDAMAPIYTPQRSV-----PEMPPQLVAAQQH--TISPQHMA 196
            ||.||..:|.:|:.||:|||..|||.::||:||||:|     |.....:|:...|  .:| ||
  Rat   133 DLTGVVAVYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETPSRQNPVVSNSSHRGDLS-QH-- 194

  Fly   197 AAAAAAAAAAAPPSTGPLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPDDYALLNEL 261
              |......|..|...|:..||||..|||||||:|:.|:.::||||:.|.|.|..|.|..||.||
  Rat   195 --ATPLPTPAVLPGDSPITPTPEQIGKLRSELEMVNGNVRVMSEMLTELVPTQVEPADLELLQEL 257

  Fly   262 TSTCKEMQSRIVDLIGRVQDDELTAEFLRINDELNNVFLRHQRYEKNRSQGQGAGVTSPSAVLGA 326
            ..||:.||.||::||.|:.:::||.|.|.|||.||||||||:|:|:.|: ||.|..:
  Rat   258 NRTCRAMQQRILELIPRISNEQLTEELLMINDNLNNVFLRHERFERFRT-GQTAKAS-------- 313

  Fly   327 AMGLPGVGAAGAGATTVATLPPPPTTTAVSNTPQSDQLL-IDLIESSEEAQLPQSLGQISLGGGA 390
                   |.|...|..:...|.|..|:.:|:     ||. :||..|...|.| |||
  Rat   314 -------GEAELAADLIDMGPDPAATSNLSS-----QLAGVDLGSSRVRAGL-QSL--------- 356

  Fly   391 PIGVQRSARPADEFDMLAQSRTDGNHKSDLLRDI-----PSVDAAAGSVTATASPYKPNQPQQAQ 450
                :.|....|:|||.|.:|  |:..:|..:.:     .:.|..||::.|            .|
  Rat   357 ----EASGHLEDDFDMFALTR--GSSLADQRKGVKYEAPQTTDGLAGALDA------------RQ 403

  Fly   451 RSAGEPPVVSKSTKENEIDEMEAWLGSSHIEGIEE---LTSSEFDKFLEERAAAAENLPTISASN 512
            :|.|..|    :|:...::::|.||.:......||   :||.||||||||||.||:.||.: ||.
  Rat   404 QSTGAIP----ATQARIMEDIEQWLSTDVGSSAEEPSGVTSEEFDKFLEERAKAADRLPNL-ASP 463

  Fly   513 SAASATTGSAGADSLRKTPKKPGAEEDLL 541
            ||........||...|||.:|   ::|:|
  Rat   464 SAEGPPRPCPGAAPRRKTQEK---DDDVL 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	85/141 (60%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	47/84 (56%)
Tom1	NP_001008366.1	VHS_Tom1	12..152	CDD:239623	85/141 (60%)
Tom1	NP_001008366.1	GAT_TOM1	214..308	CDD:260094	52/94 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334901
Domainoid	1	1.000	178	1.000	Domainoid score	I3467
eggNOG	1	0.900	-	-		E1_KOG1087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	372	1.000	Inparanoid score	I2055
OMA	1	1.010	-	-		QHG46484
OrthoDB	1	1.010	-	-		D352228at33208
OrthoFinder	1	1.000	-	-		FOG0000599
OrthoInspector	1	1.000	-	-		otm45165
orthoMCL	1	0.900	-	-		OOG6_102984
Panther	1	1.100	-	-	LDO	PTHR13856
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X466
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810