Protein Alignment CG3529 and Hrs

DIOPT Version :9

• Sequence 1: NP_648315.1
• Gene: CG3529 / 39093
• FlyBaseID: FBgn0035995
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_525099.3
• Gene: Hrs / 33458
• FlyBaseID: FBgn0031450
• Length: 760
• Species: Drosophila melanogaster
• Alignment Length: 802
• Identity: 139/802 - (17%)
• Similarity: 242/802 - (30%)
• Gaps: 320/802 - (39%)

  Fly    13 VFSTPVGQRIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYT 77
            :|.:...:.:|.||.......:|.:.:.|||.||:...|.::|..||:|:::   ..|.....|:
  Fly     1 MFRSSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMN---SPNPHSSCYS 62

  Fly    78 LTVLETCVKNCGKAFHVLVAQKDFINELVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQPDLNG 142
            |.|||:.|||||...|..|..|:........:  ::.|...:::|:|.|:|.||.||::......
  Fly    63 LLVLESIVKNCGAPVHEEVFTKENCEMFSSFL--ESTPHENVRQKMLELVQTWAYAFRSSDKYQA 125

  Fly   143 VTQMYMELKNKGIEFP-ANDLDAM-----AP---------------------------------- 167
            :......||.||..|| ..:.|||     ||
  Fly   126 IKDTMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQ 190

  Fly   168 ------------------------------------------------------------IYTPQ 172
                                                                        :.||.
  Fly   191 CTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQTPA 255

  Fly   173 RSVPE----------------------------MPPQLVAAQQHTISPQ---------------- 193
            |...:                            :||.....||.:.||:
  Fly   256 RKTEQELKEEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRSPSPEAPPEPKEYHQQPEEAT 320

  Fly   194 -------------------HMAAAAAAAAAAAAPPSTGPLHLTP------------EQAAKLRSE 227
                               ..::.|:.:|.:..||:..|..:.|            |.||.:|::
  Fly   321 NPELAKYLNRSYWEQRKISESSSMASPSAPSPMPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQ 385

  Fly   228 LEIVSNNM------------------------SILSEMLSVLKPGQESPDDYALLNELTSTCKEM 268
            :||..|.|                        |:.|:.||.:|...:....|..|.:..:..|:.
  Fly   386 VEIFVNRMKSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDS 450

  Fly   269 QSRI-------VDLIGRVQDDE-----------------LTAEFL---------RINDELNNVFL 300
            ::.:       |:.:.|:.:::                 ...|:|         ||.::...:.|
  Fly   451 RAALDQLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQL 515

  Fly   301 RHQRYEKNRSQGQGA---GVTSPSAV--LGA------------AMGLPGV---GAAGA--GATTV 343
            |.::.:.....||.|   ....||||  .|:            |.|:||.   |.|.|  |....
  Fly   516 RQEQQKAQYLMGQSAPPFPYMPPSAVPQHGSPSHQLNNVYNPYAAGVPGYLPQGPAPAPNGHGQF 580

  Fly   344 ATLPPPPTTTAVSNTPQSDQLLIDLIESSEEAQLPQSLGQISLGGGAPIGVQRSARPADEFDMLA 408
            ..:||.....|:                  :..:|.:|        .|.|:.:...|.....|:.
  Fly   581 QAIPPGMYNPAI------------------QQPMPPNL--------QPGGLMQQPAPPGNPQMMP 619

  Fly   409 QSRTD--GNHKSDLLRDIPSVDAAAGSVTATASPYKP-------NQP-----QQAQRSAGEPP-- 457
            ....:  .|:.:.:|: :|...:.|   .....|::|       .||     ||.|:..|:.|
  Fly   620 PMPENQFANNPAAILQ-LPQQHSIA---QPPQIPFQPQPQQIPGQQPQQIPGQQPQQIPGQQPQQ 680

  Fly   458 VVSKSTKENEIDEMEAWLGSSHIEGIEELTSSEFDKFLEERAA--AAENLPTISASNSAASATTG 520
            :..:..::..:.:.:......|:             .|::..|  ||:..|....:|:...|...
  Fly   681 IPGQQPQQIPVQQPQPQPQMGHV-------------MLQQHQAPPAAQAPPVTEIANNQVQAVAA 732

  Fly   521 SAGADSLRKTPKKPGAEEDLLA 542
            :.........|....|||...|
  Fly   733 APAPPQNEPGPAPVKAEEPATA 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	41/140 (29%)
		GAT_TOM1_like	222..307	CDD:260091	22/141 (16%)
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	44/145 (30%)
		FYVE_Hrs	157..217	CDD:277260	0/59 (0%)
		Hrs_helical	377..471	CDD:289018	18/93 (19%)
		GBP_C	<456..520	CDD:303769	8/63 (13%)
		coiled coil	501..512	CDD:293879	2/10 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438663
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840