DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3529 and Tom1l1

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001240788.1	Gene:	Tom1l1 / 287622	RGDID:	1562626	Length:	474	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	145/506 - (28%)
Similarity:	251/506 - (49%)	Gaps:	82/506 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FSTPVGQRIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYTL 78
            ::|.:|..||.||.|.:.:|:|...|.|||:||.:.|..:||::|::||:|:|  .|::.:..:|
  Rat    11 YATSLGHLIEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRISKN--YNHKEIQLSL 73

  Fly    79 TVLETCVKNCGKAFHVLVAQKDFINE-LVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQPDLNG 142
            ::::.|::|||.:|..|:.:|:|:.: ||||:.|:...|...|.::||.|::|:..|....|::.
  Rat    74 SLIDMCMQNCGPSFQSLIVKKEFVKDTLVKLLNPRYTLPLETQNRILSFIKMWSQGFPGGVDVSE 138

  Fly   143 VTQMYMELKNKGIEFPANDLDAMAPIYTPQRSVPEMPPQLVAAQQHTISPQH-MAAAAAAAAAAA 206
            |.::|::|..||::||            |....||...:  |.|   |||.. .:...|.|.::.
  Rat   139 VKEVYLDLLKKGVQFP------------PLDGEPETKQE--AGQ---ISPSRPTSVPTAPALSSI 186

  Fly   207 APPSTGPLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPDDYALLNELTSTCKEMQSR 271
            ..|....:.|.|||..||.|||::|..|:.:::.:|....||.|:.:|..||.:|..|.:|||.|
  Rat   187 IAPKNPTISLVPEQIGKLHSELDMVKMNVKVMTAILMENTPGSENHEDIELLRKLYKTGREMQER 251

  Fly   272 IVDLIGRVQDDELTAEFLRINDELNNVFLRHQRYEKN--------RSQGQGAGVTSPSAV----- 323
            |:||:..|:::::|.|.:::|::|||..|.::|:.:|        |:..:....:.|||.
  Rat   252 IMDLLVVVENEDVTVELIQVNEDLNNAILGYERFTRNQQRLLEQKRNPTEANTSSEPSAPSCDLL 316

  Fly   324 -LGAAMGLP--------GVGAAGAGATTVATLPPPPTTTAVSNTPQSDQLLIDLIESSEEAQLPQ 379
             ||....:|        .|.|..:|....:..|........|..||.|.|      :||:.::|
  Rat   317 NLGPVAPVPVSSEGPLNSVNAQLSGLNVSSQSPVITNNLYPSLQPQMDLL------ASEDTEVP- 374

  Fly   380 SLGQISLGGGAPIGVQRSARPADEFDMLAQSRTDGN---HKSDLLRDIPSVDAAAGSVTATASPY 441
                       .:..||:::      .||.|.|..|   |.|.:|....|:..|..:.::...|.
  Rat   375 -----------TLFPQRTSQ------NLASSHTYDNFPDHSSSVLLQPVSLHTAPAAPSSQRLPP 422

  Fly   442 KPNQPQQAQRSAGEPPVVSK--------STKENEIDEMEAWLGSSHIEGIE 484
            .|:.....:.||.:||...:        .|.|...:|::|    ||.:|.:
  Rat   423 LPSNHPVLKNSALQPPSYYEVMEFDPLAPTTEAIYEEIDA----SHKKGAQ 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	50/141 (35%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	32/84 (38%)
Tom1l1	NP_001240788.1	VHS_Tom1	14..154	CDD:239623	50/141 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..175		8/24 (33%)
		GAT_TM1L1	198..289	CDD:260095	35/90 (39%)
		Interaction with GRB2. /evidence=ECO:0000250	391..394		0/2 (0%)
		SH3-binding. /evidence=ECO:0000250	420..424		1/3 (33%)
		Interaction with PIK3R1. /evidence=ECO:0000250	441..444		0/2 (0%)
		SH2-binding. /evidence=ECO:0000250	457..460		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334900
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352228at33208
OrthoFinder	1	1.000	-	-		FOG0000599
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13856
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X466
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850