DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3529 and Gga3

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_766636.2	Gene:	Gga3 / 260302	MGIID:	2384159	Length:	718	Species:	Mus musculus

Alignment Length:	601	Identity:	132/601 - (21%)
Similarity:	220/601 - (36%)	Gaps:	130/601 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GQRIEA----ATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYTLT 79
            |:.:|:    ||:.:...|:|...:..||.||:..:..:.|:|.:..::.   .......:..||
Mouse     6 GESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQ---SPQEWEAVQALT 67

  Fly    80 VLETCVKNCGKAFHVLVAQKDFINELVKLIGPK---NDPPAAMQEKVLSLIQIWADAFKNQPDLN 141
            |||.|:||||:..|..|.:..|:|||:|::.||   :.....::.||:.|:..|..|.   |:..
Mouse    68 VLEACMKNCGRRLHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLFSWTLAL---PEEA 129

  Fly   142 GVTQMYMELKNKGIEFPANDLDAMAPIYTPQRSVPEMPP-------------QLVAAQQHTISPQ 193
            .:...|..||.:||      :.:..||...:..:|..||             :|:|....:.:|.
Mouse   130 KIKDAYHMLKRQGI------VQSDPPIPMDRTLIPSPPPRPKNPVFDDEEKSKLLARLLKSKNPD 188

  Fly   194 HMAAAAAAAAAAAAPPSTGPLHLTPEQAAKLRS------ELEIVSNNMSILSEMLSVLKPGQESP 252
            .:..|.....:           :..|..|:::.      .||.|:||:.:|.|||........|.
Mouse   189 DLQEANRLIKS-----------MVKEDEARIQKVTKRLHTLEEVNNNVKLLHEMLLHYSQEYSSD 242

  Fly   253 DDYALLNELTSTCKEMQSRIVDLIGRVQD-DELTAEFLRINDELNNVFLRHQR-YEKNRSQGQGA 315
            .|..|:.||...|:..:..:..|....:| |....:.|:.:|.|:.|...::. .|.....|:..
Mouse   243 ADKELMKELFDRCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQIVNGEVT 307

  Fly   316 GVTSPSAV-------LGAAMGLPGVGAAGAGATTVA-------TLPPPPTTTAVSNTPQSDQLLI 366
            ..|.|.:.       .||.:.|..:.|....:..:|       .|||||.|   |..|:|
Mouse   308 TSTMPDSEGNSHCGNQGALIDLAELDAPSNSSPALAPPTSGIPILPPPPQT---SGPPRS----- 364

  Fly   367 DLIESSEEAQLP--------------QSLGQISLGGGAPIGVQRSA----------RPADEFDML 407
               .||.:|:.|              :.|..:.|...||...:.|.          .|..:.|..
Mouse   365 ---RSSSQAEAPPGSDSTNNALSLLDEELLCLGLTDPAPTAPKESPGSSQWHLFQNEPPSDLDFF 426

  Fly   408 AQSRTDGNHKSDLLRDIPSVDAAAGSVTATASPYKPNQPQQAQRSAGEP-PVVSKSTKENEIDEM 471
            :.            |.:|:....:.. .....|...:...||...|..| |||..|...:.....
Mouse   427 SP------------RPVPAASCPSDG-PQLPPPVSTSSMSQAPLPAAFPAPVVPASAPTHSTGSF 478

  Fly   472 -------EAWLGSSHIEGIEELTSS------EFDKFLEERAAAAENLPTISASNSAASAT---TG 520
                   .|....:..:|.|..:||      ..|:.|||....:..:..:|..:...:|:   ..
Mouse   479 MFSSGPAPALAPKAEPKGPEYPSSSTSHRLDALDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPA 543

  Fly   521 SAGADSLRKTPKKPGA 536
            ||.|..|......||:
Mouse   544 SAPARPLLPFSTGPGS 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	42/145 (29%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	23/92 (25%)
Gga3	NP_766636.2	VHS_GGA	8..146	CDD:239624	41/149 (28%)
		GAT_GGA3	213..299	CDD:260098	22/85 (26%)
		Unstructured hinge	299..588		56/285 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..381		15/57 (26%)
		Autoinhibitory. /evidence=ECO:0000250	387..391		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..455		9/72 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..506		5/28 (18%)
		Alpha_adaptinC2	596..710	CDD:197886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1087
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840