DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3529 and Tom1

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001129731.1	Gene:	Tom1 / 21968	MGIID:	1338026	Length:	516	Species:	Mus musculus

Alignment Length:	555	Identity:	236/555 - (42%)
Similarity:	322/555 - (58%)	Gaps:	69/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGNVFSTPVGQRIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVV 74
            |||.||:|||||||.|||.:|.||:||.||||||:|||:.:..:||.||::||:..|  ||...|
Mouse     5 LGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDAFRAVKKRIMGN--KNFHEV 67

  Fly    75 MYTLTVLETCVKNCGKAFHVLVAQKDFI-NELVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQP 138
            |..||||||||||||..||||||.:||: |.||:.|.|||:||..:.:|||:|||.|||||::.|
Mouse    68 MLALTVLETCVKNCGHRFHVLVANQDFVENVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSP 132

  Fly   139 DLNGVTQMYMELKNKGIEFPANDLDAMAPIYTPQRSV--PEMPPQLVAAQQHTISPQHMAAAAAA 201
            ||.||..:|.:|:.||:|||..|||.::||:||||:|  .|.|.:..:...:|.....::..|..
Mouse   133 DLTGVVAVYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETPSRQNSVSSNTSQRGDLSQHATP 197

  Fly   202 AAAAAAPPSTGPLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPDDYALLNELTSTCK 266
            ....|..|...|:..||||..|||||||:||.|:.::||||:.|.|.|..|.|..||.||..||:
Mouse   198 LPTPAVLPGDSPITPTPEQIGKLRSELEMVSGNVRVMSEMLTELVPTQVEPADLELLQELNRTCR 262

  Fly   267 EMQSRIVDLIGRVQDDELTAEFLRINDELNNVFLRHQRYEKNRSQGQGAGVTSPSAVLGAAMGLP 331
            .||.||::||.|:.:::||.|.|.|||.||||||||:|:|:.|: ||.|..:|.:.:
Mouse   263 AMQQRILELIPRISNEQLTEELLMINDNLNNVFLRHERFERFRT-GQTAKASSEAEL-------- 318

  Fly   332 GVGAAGAGATTVATLPPPPTTTAVSNTPQSDQL------LID-----LIESSEEAQLP-QSLGQI 384
                    ||.:..:.|.|..|  :|.  |.||      |:.     |:|..::...| |.||..
Mouse   319 --------ATDLIDMGPDPAAT--NNL--SSQLAGMNNRLLSLSNHFLLEEGKKEWAPLQDLGSR 371

  Fly   385 SLGGGAPIGVQRSARPADEFDMLAQSRTDGNHKSDLLRDI-----PSVDAAAGSVTATASPYKPN 444
            |:..|.. .::.|....|:|||.|.:|  |:..:|..:.:     .:.|..||::.|
Mouse   372 SVRAGLQ-SLETSGHLEDDFDMFALTR--GSSLADQRKGVKYEAPQTTDGLAGALDA-------- 425

  Fly   445 QPQQAQRSAGEPPVVSKSTKENEIDEMEAWLGSSHIEGIEE---LTSSEFDKFLEERAAAAENLP 506
                .|:|.|..|    :|:...::::|.||.:......||   :||.||||||||||.||:.||
Mouse   426 ----RQQSTGAIP----ATQARIMEDIEQWLSTDVGNSAEEPSGVTSEEFDKFLEERAKAADRLP 482

  Fly   507 TISASNSAASATTGSAGADSLRKTPKKPGAEEDLL 541
            .: ||.||......|.|....|||.:|   ::|:|
Mouse   483 NL-ASPSAEGPPRPSPGTAPRRKTQEK---DDDML 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	85/141 (60%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	48/84 (57%)
Tom1	NP_001129731.1	VHS_Tom1	12..152	CDD:239623	85/141 (60%)
Tom1	NP_001129731.1	GAT_TOM1	214..308	CDD:260094	53/94 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831179
Domainoid	1	1.000	178	1.000	Domainoid score	I3545
eggNOG	1	0.900	-	-		E1_KOG1087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	372	1.000	Inparanoid score	I2096
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46484
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000599
OrthoInspector	1	1.000	-	-		otm43099
orthoMCL	1	0.900	-	-		OOG6_102984
Panther	1	1.100	-	-	LDO	PTHR13856
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X466
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760