DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3529 and TOM1L2

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001337261.1	Gene:	TOM1L2 / 146691	HGNCID:	11984	Length:	536	Species:	Homo sapiens

Alignment Length:	578	Identity:	244/578 - (42%)
Similarity:	326/578 - (56%)	Gaps:	90/578 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGNVFSTPVGQRIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVV 74
            |||.|||||||.:|.|||.:|.||:|..||||||:|||:.:..:||:||::|||  |..:|.:.|
Human     5 LGNPFSTPVGQCLEKATDGSLQSEDWTLNMEICDIINETEEGPKDAIRALKKRL--NGNRNYREV 67

  Fly    75 MYTLTVLETCVKNCGKAFHVLVAQKDFINE-LVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQP 138
            |..||||||||||||..||:|||.:|||:. |||:|.|||:||..:|:|||:|||.|||||::.|
Human    68 MLALTVLETCVKNCGHRFHILVANRDFIDSVLVKIISPKNNPPTIVQDKVLALIQAWADAFRSSP 132

  Fly   139 DLNGVTQMYMELKNKGIEFPANDLDAMAPIYTPQRSVPEMPPQLV----AAQQHTISPQHMAAAA 199
            ||.||..:|.|||.||:|||..||||::||:||||||||:.|...    .:||.|.:..:.:...
Human   133 DLTGVVHIYEELKRKGVEFPMADLDALSPIHTPQRSVPEVDPAATMPRSQSQQRTSAGSYSSPPP 197

  Fly   200 AAAAAAAAP--PSTGPLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPDDYALLNELT 262
            |..:|..||  ..|||:....||.|:|||||::|..|..::||||:.:.||||...|..||.||.
Human   198 APYSAPQAPALSVTGPITANSEQIARLRSELDVVRGNTKVMSEMLTEMVPGQEDSSDLELLQELN 262

  Fly   263 STCKEMQSRIVDLIGRVQDDELTAEFLRINDELNNVFLRHQRYEKNRS----QGQGAGV---TSP 320
            .||:.||.|||:||.||.::|:|.|.|.:||:|||||||::|:|:.||    |....||   .:.
Human   263 RTCRAMQQRIVELISRVSNEEVTEELLHVNDDLNNVFLRYERFERYRSGRSVQNASNGVLNEVTE 327

  Fly   321 SAVLGAAMGLPGVGAAGAGATTVATLPPPPTTTAVSNTPQSDQLLIDLIESSEEAQLPQSLGQIS 385
            ..::....|.|.|.:...|.|.      ||::.                 ||:.|.|  .||..|
Human   328 DNLIDLGPGSPAVVSPMVGNTA------PPSSL-----------------SSQLAGL--DLGTES 367

  Fly   386 LGGGAPIGVQRSARPADEFDMLAQSRTDGNHKSDLLRDIPSVDAAAGSVTATASPYKPNQPQQAQ 450
            :.|  .:...:...|.|.|||.||:|  ||..::..:.:...|..|....|:|   ..|:.|.::
Human   368 VSG--TLSSLQQCNPRDGFDMFAQTR--GNSLAEQRKTVTYEDPQAVGGLASA---LDNRKQSSE 425

  Fly   451 ---------RSAG-----EP-----------PVVSKSTKENEIDEMEAWL-----GSSHIEGIEE 485
                     |..|     ||           ||...|.    :|::|.||     |....||:
Human   426 GTFLSSAQKRGRGGESDLEPIDSWLITQGMIPVAQPSV----MDDIEVWLRTDLKGDDLEEGV-- 484

  Fly   486 LTSSEFDKFLEERAAAAENLPTISASNSAASATTGSAGADSLRKTPKKPGAEEDLLAL 543
             ||.||||||||||.|||.:|.:.:....|.|   .|...|.||.|::  :|:.|.||
Human   485 -TSEEFDKFLEERAKAAEMVPDLPSPPMEAPA---PASNPSGRKKPER--SEDALFAL 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	85/141 (60%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	46/84 (55%)
TOM1L2	NP_001337261.1	VHS_Tom1L2	12..148	CDD:340793	82/137 (60%)
TOM1L2	NP_001337261.1	GAT_TM1L2	218..309	CDD:260096	49/90 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	179	1.000	Domainoid score	I3543
eggNOG	1	0.900	-	-		E1_KOG1087
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H44901
Inparanoid	1	1.050	372	1.000	Inparanoid score	I2123
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46484
OrthoDB	1	1.010	-	-		D1213216at2759
OrthoFinder	1	1.000	-	-		FOG0000599
OrthoInspector	1	1.000	-	-		otm41029
orthoMCL	1	0.900	-	-		OOG6_102984
Panther	1	1.100	-	-	O	PTHR13856
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	1	1.000	-	-		X466
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870