DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3529 and Gga1

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_666041.1	Gene:	Gga1 / 106039	MGIID:	2146207	Length:	635	Species:	Mus musculus

Alignment Length:	535	Identity:	134/535 - (25%)
Similarity:	219/535 - (40%)	Gaps:	86/535 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYTLTVLETCV 85
            ||..||:......|||:....|:.:||..:....|.|.:..::.   .......:..|||||||:
Mouse    13 RINRATNPLNKELNWASINSFCEQLNEDFEGPPLATRLLAHKIQ---SPQEWEAIQALTVLETCM 74

  Fly    86 KNCGKAFHVLVAQKDFINELVKLIGPK---NDPPAAMQEKVLSLIQIWADAFKNQPDLNGVTQMY 147
            |:|||.||..|.:..|:|||:|::.||   :.....::.|:|.|:..|....   |:...:.:.|
Mouse    75 KSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKSKILELLYSWTVCL---PEEVKIAEAY 136

  Fly   148 MELKNKGI--EFPANDLDAMAPIYTPQ-RSV---PEMPPQLVAAQQHTISPQHMAAAAAAAAAAA 206
            ..||.:||  ..|....||:.|:..|: ::|   .|...:::|....:..|:.:.||........
Mouse   137 QMLKKQGIVKSDPKLPEDAIFPLPPPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMV 201

  Fly   207 APPSTGPLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPDDYALLNELTSTCKEMQSR 271
            .....     ..|:.:|..:.:|.|:||:.:|:||:.....|..|.....|:.||...|:.|:..
Mouse   202 QEDQK-----RMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGAASSSSEDLMKELYQRCERMRPT 261

  Fly   272 IVDLIGRVQD-DELTAEFLRINDELNNVFLRHQRYEKNRSQGQGAGVTSPSAVLGAAMGLPGVGA 335
            :..|....:| ||..||.|:.||.|..|...:::..:.......|..:|......|.:.|.|:
Mouse   262 LFRLASDTEDNDEALAEILQANDNLTQVINLYKQLVRGEEVNGDATASSIPGSTSALLDLSGL-- 324

  Fly   336 AGAGATTVATLPPPPTTTAVSNTPQSDQLLIDLIESSEEAQLPQSLGQI-----SLG---GGAPI 392
                     .||||.||...:.|...:|       ||.| ||..|:..:     |||   ...|.
Mouse   325 ---------DLPPPGTTQPATPTRPGNQ-------SSPE-QLSASVSLLDDELMSLGLSDPTPPS 372

  Fly   393 GVQRSARPADEFDMLAQSRTDGNHKSDLLRDIPSVDAAAGSVTATASPYKPNQPQQAQRSAGEPP 457
            |....:...|.|    || :||...|     :|                   .|.||......||
Mouse   373 GTSSDSVGWDNF----QS-SDGTESS-----VP-------------------PPAQAPSMDCRPP 408

  Fly   458 VVSKSTKENEIDEMEAWLGSSHIEGIEELTSSEFDKFLEERAAAAENLPTISASNSAASATTGSA 522
            ..:.....:.:|:::. ||.:.   :::....|..:...|:...|   |.::..:..:.:::.|.
Mouse   409 AQAPPPTSSGLDDLDL-LGKTL---MQQALPPEAQQVRWEKQQPA---PRLTLRDLQSKSSSPSP 466

  Fly   523 GADSLRKT--PKKPG 535
            ||.||..|  |:.||
Mouse   467 GAASLLHTTSPEPPG 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	43/141 (30%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	26/85 (31%)
Gga1	NP_666041.1	VHS_GGA	9..147	CDD:239624	43/139 (31%)
		Interaction with ARF3. /evidence=ECO:0000250	114..273		39/166 (23%)
		DUF327	<180..234	CDD:294489	12/58 (21%)
		GAT_GGA1_GGA2	210..298	CDD:260097	26/87 (30%)
		Unstructured hinge	299..505		53/238 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..349		16/62 (26%)
		Autoinhibitory. /evidence=ECO:0000250	357..361		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..422		19/88 (22%)
		DUF1176	<382..>445	CDD:284160	17/95 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..490		9/27 (33%)
		Alpha_adaptinC2	513..627	CDD:197886
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2130
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940