DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3529 and TOM1

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001129204.1	Gene:	TOM1 / 10043	HGNCID:	11982	Length:	493	Species:	Homo sapiens

Alignment Length:	549	Identity:	234/549 - (42%)
Similarity:	316/549 - (57%)	Gaps:	80/549 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGNVFSTPVGQRIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVV 74
            |||.||:|||||||.|||.:|.||:||.||||||:|||:.:..:||:||::||:..|  ||...|
Human     5 LGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVGN--KNFHEV 67

  Fly    75 MYTLTVLETCVKNCGKAFHVLVAQKDFINE-LVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQP 138
            |..||||||||||||..||||||.:||:.. ||:.|.|||:||..:.:|||:|||.|||||::.|
Human    68 MLALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSP 132

  Fly   139 DLNGVTQMYMELKNKGIEFPANDLDAMAPIYTPQRSVPEMPPQLVAAQQHTISPQHMAAAAAAAA 203
            ||.||..:|.:|:.||:|||..|||.::||:||||:|.....|.......|.|.|...:...||.
Human   133 DLTGVVTIYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDSVGTDSSQQEDSGQHAAP 197

  Fly   204 AAAAPPSTG--PLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPDDYALLNELTSTCK 266
            ..|.|..:|  |:..||||..|||||||:||.|:.::||||:.|.|.|..|.|..||.||..||:
Human   198 LPAPPILSGDTPIAPTPEQIGKLRSELEMVSGNVRVMSEMLTELVPTQAEPADLELLQELNRTCR 262

  Fly   267 EMQSRIVDLIGRVQDDELTAEFLRINDELNNVFLRHQRYEKNRSQGQGAGVTSPSAVLGAA---- 327
            .||.|:::||.::.:::||.|.|.:||.||||||||:|:|:.|:   |....:||....||
Human   263 AMQQRVLELIPQIANEQLTEELLIVNDNLNNVFLRHERFERFRT---GQTTKAPSEAEPAADLID 324

  Fly   328 MGLPGVGAAGAGATTVATLPPPPTTTAVSNTPQSDQLL-IDLIESSEEAQLPQSLGQISLGGGAP 391
            ||                 |.|..|..:|:     ||. ::|..||..|.| |||
Human   325 MG-----------------PDPAATGNLSS-----QLAGMNLGSSSVRAGL-QSL---------- 356

  Fly   392 IGVQRSARPADEFDMLAQSRTDGNHKSDLLRDI-----PSVDAAAGSVTATASPYKPNQPQQAQR 451
               :.|.|..|||||.|.:|  |:..:|..:::     .:.|..||::.|            .|:
Human   357 ---EASGRLEDEFDMFALTR--GSSLADQRKEVKYEAPQATDGLAGALDA------------RQQ 404

  Fly   452 SAGEPPVVSKSTKENEIDEMEAWLGSSHIEGIEE---LTS-SEFDKFLEERAAAAENLPTISASN 512
            |.|..||    |:...::::|.||.:......||   :|| .:|||||||||.||:.||.:| |.
Human   405 STGAIPV----TQACLMEDIEQWLSTDVGNDAEEPKGVTSEGKFDKFLEERAKAADRLPNLS-SP 464

  Fly   513 SAASATTGSAGADSLRKTPKKPGAEEDLL 541
            ||.......:|....:||.:|   ::|:|
Human   465 SAEGPPGPPSGPAPRKKTQEK---DDDML 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	84/141 (60%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	45/84 (54%)
TOM1	NP_001129204.1	VHS_Tom1	12..152	CDD:239623	84/141 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..212		10/40 (25%)
		GAT_TOM1	214..308	CDD:260094	50/96 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..336		10/45 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141235
Domainoid	1	1.000	179	1.000	Domainoid score	I3543
eggNOG	1	0.900	-	-		E1_KOG1087
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	372	1.000	Inparanoid score	I2123
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46484
OrthoDB	1	1.010	-	-		D352228at33208
OrthoFinder	1	1.000	-	-		FOG0000599
OrthoInspector	1	1.000	-	-		otm41029
orthoMCL	1	0.900	-	-		OOG6_102984
Panther	1	1.100	-	-	LDO	PTHR13856
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X466
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770