DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3529 and tom1l1

DIOPT Version :9

Sequence 1:	NP_648315.1	Gene:	CG3529 / 39093	FlyBaseID:	FBgn0035995	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001192093.1	Gene:	tom1l1 / 100170155	XenbaseID:	XB-GENE-494135	Length:	477	Species:	Xenopus tropicalis

Alignment Length:	510	Identity:	156/510 - (30%)
Similarity:	248/510 - (48%)	Gaps:	81/510 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FSTPVGQRIEAATDANLASENWAANMEICDMINESSDTARDAMRAIRKRLSQNAGKNNQVVMYTL 78
            ||||||..|:..|.:.|.:|:|...|.|||:||.::|..:||::|.|||:.:|  .|.:.|.::|
Frog    11 FSTPVGHLIDIHTASTLQNEDWGQFMNICDVINTTADGPKDAVKAFRKRICRN--YNQKEVKFSL 73

  Fly    79 TVLETCVKNCGKAFHVLVAQKDFINE-LVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNQPDLNG 142
            .:||.|::||...||.||.:|||..: |||::.||.:.|.::|.|:|.||..|:...|.:.:...
Frog    74 LLLEMCMQNCVPTFHSLVLKKDFSKDVLVKMLNPKYNLPVSLQNKILFLIMTWSHDPKWKINATE 138

  Fly   143 VTQMYMELKNKGIEFPANDLDAMAPIYTPQRSVPEMPPQLVAA--QQHTISPQHMAAAAAAAAAA 205
            :.::|:||..:||:||:  |.....:...|    |.|.|.:.:  ..|:.:..|
Frog   139 IREVYLELIKRGIKFPS--LQENGEMLETQ----ESPKQSIQSPLSHHSKTDLH----------- 186

  Fly   206 AAPPSTGPLHLTPEQAAKLRSELEIVSNNMSILSEMLSVLKPGQESPDDYALLNELTSTCKEMQS 270
                     :|||||..||.||:::|..|:.::||:|...:.|.|:|:|..||.||...|.|||.
Frog   187 ---------NLTPEQIGKLYSEMDMVRMNVKVMSEILLETRLGAENPEDMDLLEELHKACLEMQR 242

  Fly   271 RIVDLIGRVQDDELTAEFLRINDELNNVFLRHQRYEK--------NRSQGQ-----GAGVTSPSA 322
            ||:.|:..||::::..|.:::||:||||||||:|:.:        :|.|.:     ..|.|:|.:
Frog   243 RILTLVETVQNEDVIIELVQVNDDLNNVFLRHERFSRAKANQSAEHRRQAEIMTFDDNGPTAPLS 307

  Fly   323 VLGAAMGLPG-----VGAAGAGATTVATLPPPPTTTAVSNTPQSDQLLIDLIESSEEAQLPQSLG 382
            .| ..:.:|.     |.:.|. .....|:|..|..|...:.|.         :|..|.::|....
Frog   308 EL-IDLNVPSGPVHPVHSNGF-LLPAPTMPMHPWPTHTPHFPD---------KSGLENRVPFLYP 361

  Fly   383 QISLGG-------GAPIGVQ-RSARPADEFDMLAQSRTDGNHKSDLLRDIPSVDAAAGSVTATAS 439
            |:.|.|       ...:||| ....|.:.:|......|       ||..:|::     |.|....
Frog   362 QMDLQGLREAVDTRFELGVQLPEVPPQNIYDNTPAEPT-------LLPTVPAL-----SPTVLLI 414

  Fly   440 PYKPNQPQQAQRSAGEPPVVSKSTKENEIDEMEAWLGSSHIEGI-EELTSSEFDK 493
            |..|...|.|:..:|.....|......|:.|.:....|:..|.| ||:.:|.:.|
Frog   415 PNNPTSKQLAENKSGASENNSLLPNYYELLEFDPLAESNRTEVIYEEIDTSLWRK 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3529	NP_648315.1	VHS_Tom1	17..158	CDD:239623	55/141 (39%)
CG3529	NP_648315.1	GAT_TOM1_like	222..307	CDD:260091	38/84 (45%)
tom1l1	NP_001192093.1	VHS_ENTH_ANTH	14..154	CDD:295355	55/141 (39%)
tom1l1	NP_001192093.1	GAT_SF	190..281	CDD:296121	41/90 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352228at33208
OrthoFinder	1	1.000	-	-		FOG0000599
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13856
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X466
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020