DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTF-1 and GLIS2

DIOPT Version :9

Sequence 1:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_001305847.1	Gene:	GLIS2 / 84662	HGNCID:	29450	Length:	524	Species:	Homo sapiens

Alignment Length:	498	Identity:	111/498 - (22%)
Similarity:	158/498 - (31%)	Gaps:	165/498 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 FTLEYQFENQRLVQVQPPTVVSLSMVSSPNEAANPPINCDNDQGTGN-SISRDSTSNSPAYFTIE 269
            |.|..:|..:...:.....:|.||:        :||...|:..|:.: |..|....:.|...:..
Human    59 FLLNSKFPEKVEGRFSAAPLVDLSL--------SPPSGLDSPNGSSSLSPERQGNGDLPPVPSAS 115

  Fly   270 TSYVDEYDPNEPDEDEQLAHCIQPGVLHQDVDEEEVERQDENDQLMALAY--ESSDEALS----- 327
            ......|....|...:........|.||                |.|.::  ...|:.||
Human   116 DFQPLRYLDGVPSSFQFFLPLGSGGALH----------------LPASSFLTPPKDKCLSPDLPL 164

  Fly   328 --RYRCNYENCYRSYSTIGNLRTHLKTHTGDYSFKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYE 390
              :..|.:..|.:.:    .|...|..|..||..| ||                     |...|.
Human   165 PKQLVCRWAKCNQLF----ELLQDLVDHVNDYHVK-PE---------------------KDAGYC 203

  Fly   391 CEVSGC---DKAFNTRYRLHAHLRLH-NGETFNCELCQKCFTTLSDLKKHMRTHTQERPYKCPED 451
            |...||   .:.||.||::..|:|.| |.:...|..|.|.|:.|.:||.|.|:||.|:||.||.:
Human   204 CHWEGCARHGRGFNARYKMLIHIRTHTNEKPHRCPTCSKSFSRLENLKIHNRSHTGEKPYVCPYE 268

  Fly   452 DCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFSTSHSLKSHKKTHQRQLQNKGRKKRPLKT 516
            .|.|.::.|.....|.|||..:|||.|:...|.|.::...||:.|.|.|
Human   269 GCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSLRKHIKAH---------------- 317

  Fly   517 QQTKCSDQEQKDPQQEEQEEEEFIKEDQPEMTLLNPGSHCSETTSTDSGVVLQTLTPQDHLSNVF 581
                                ..|:..:|.|:..|.|                   .|:
Human   318 --------------------GHFVSHEQQELLQLRP-------------------PPK------- 336

  Fly   582 ILQGNEPLILPETSQAYQLSYAAEEEIPSPWIDAGVLVSKPIIPMAPLTDACVALPTEMPSFVNL 646
                 .||..|:......   .|:..||:|    ..|...|.:|..||..|        |..::|
Human   337 -----PPLPAPDGGPYVS---GAQIIIPNP----AALFGGPGLPGLPLPLA--------PGPLDL 381

  Fly   647 KPTF-----GNAVSGNMGDPQPETMDVDPTVETSLPTPTLELN 684
            ....     |:...|.||              ..||.|.|.||
Human   382 SALACGNGGGSGGGGGMG--------------PGLPGPVLPLN 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	45/145 (31%)
		C2H2 Zn finger	331..353	CDD:275368	4/21 (19%)
		zf-H2C2_2	345..372	CDD:290200	8/26 (31%)
		C2H2 Zn finger	361..383	CDD:275368	2/21 (10%)
		zf-H2C2_2	375..402	CDD:290200	6/29 (21%)
		C2H2 Zn finger	391..413	CDD:275368	9/24 (38%)
		zf-C2H2	418..440	CDD:278523	9/21 (43%)
		C2H2 Zn finger	420..440	CDD:275368	9/19 (47%)
		zf-H2C2_2	432..458	CDD:290200	13/25 (52%)
		COG5048	442..>519	CDD:227381	23/76 (30%)
		C2H2 Zn finger	448..470	CDD:275368	7/21 (33%)
		zf-H2C2_2	462..489	CDD:290200	10/26 (38%)
		C2H2 Zn finger	478..500	CDD:275368	7/21 (33%)
		DUF3682	862..>931	CDD:289231
GLIS2	NP_001305847.1	Interaction with CTNND1. /evidence=ECO:0000250	35..174		24/138 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..62		1/2 (50%)
		Transcription activation. /evidence=ECO:0000250	71..137		12/73 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..114		7/29 (24%)
		Transcription repression. /evidence=ECO:0000250	148..171		3/22 (14%)
		C2H2 Zn finger	213..229	CDD:275368	6/15 (40%)
		COG5048	233..>327	CDD:227381	36/129 (28%)
		C2H2 Zn finger	237..257	CDD:275368	9/19 (47%)
		C2H2 Zn finger	265..287	CDD:275368	7/21 (33%)
		C2H2 Zn finger	295..317	CDD:275368	7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4667
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960