DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTF-1 and MTF1

DIOPT Version :9

Sequence 1:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_005946.2	Gene:	MTF1 / 4520	HGNCID:	7428	Length:	753	Species:	Homo sapiens

Alignment Length:	743	Identity:	225/743 - (30%)
Similarity:	320/743 - (43%)	Gaps:	223/743 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   270 TSYVDEYDP---NEPDEDEQ---------------------------LAHCIQPGVLHQDVD--E 302
            |:.:.|.||   .:.|:|.|                           :.|.|.|..:|..::  .
Human    47 TTVLIEQDPGTLEDEDDDGQCGEHLPFLVGGEEGFHLIDHEAMSQGYVQHIISPDQIHLTINPGS 111

  Fly   303 EEVERQDEND--QLMALAYESSDEALSRYRCNYENCYRSYSTIGNLRTHLKTHTGDYSFKCPEDG 365
            ..:.|..|..  .|.:...|:..:.:.||:|.:|.|.|:|||.||||||.|||.|:|:|.|.::|
Human   112 TPMPRNIEGATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEG 176

  Fly   366 CHKAFLTSYSLKIHVRVHTKVKPYECEVSGCDKAFNTRYRLHAHLRLHNGETFNCEL--CQKCFT 428
            |.|||||||||:||||||||.||:||:|.||:|||||.|||.||.|||.|:|||||.  |.|.||
Human   177 CGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCSKYFT 241

  Fly   429 TLSDLKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFSTSHSL 493
            |||||:||:||||.|:|::|..|.|||||.||||||||.||||||:|:.|..:.|:|:|||.:||
Human   242 TLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSL 306

  Fly   494 KSHKKTHQRQLQNKGRKKRPLKTQQTKCSDQEQKDPQQEEQEE--EEFIKEDQPEMTLLNPGSHC 556
            |||.|.|    .|||.....|              ||....|:  ......|   ::||:..|..
Human   307 KSHMKGH----DNKGHSYNAL--------------PQHNGSEDTNHSLCLSD---LSLLSTDSEL 350

  Fly   557 SETTSTDSGVVLQTLTPQDHLSNVF---------------------------------------- 581
            .|.:||..|..|.|::|.....::|
Human   351 RENSSTTQGQDLSTISPAIIFESMFQNSDDTAIQEDPQQTASLTESFNGDAESVSDVPPSTGNSA 415

  Fly   582 ------ILQ----------------------------------GNEPLIL--PETSQAYQLSYAA 604
                  :||                                  ||.|.:|  ||....:...:||
Human   416 SLSLPLVLQPGLSEPPQPLLPASAPSAPPPAPSLGPGSQQAAFGNPPALLQPPEVPVPHSTQFAA 480

  Fly   605 --EEEIPSPWIDAGVLVSKPIIP----------MAPLTDACVALP------TE-MPSFVNLKPTF 650
              :|.:|.|      ...:||:|          .|....:.||.|      || :|:.|...|..
Human   481 NHQEFLPHP------QAPQPIVPGLSVVAGASASAAAVASAVAAPAPPQSTTEPLPAMVQTLPLG 539

  Fly   651 GNAVSGNMGDPQPETMDVDPTVETSLPTPTLELNQPNIEELLK--QDSFENEEDMETESLLNDIL 713
            .|:|..|  :|   |:.:.||..|::...:|.:.:.|::.:|.  ..|.:|:|.::..|.:..:.
Human   540 ANSVLTN--NP---TITITPTPNTAILQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEKVF 599

  Fly   714 MTIDNNSALLQATLQQASQVP---SDASGLVELDIRDNKPTLKQITADAGICNCTNCKC------ 769
            .|               :.||   |..|.:.::.:......:||..|    |.| .|.|
Human   600 FT---------------TAVPVASSPGSSVQQIGLSVPVIIIKQEEA----CQC-QCACRDSAKE 644

  Fly   770 ---DQTKSC----------HGGDCGAAAAQQTTRTGAPTTTTTTTTMNSSGGKRICGSVVPTKKV 821
               .:.|.|          ...|..:......|.:.||...::::|:.||     |......:..
Human   645 RASSRRKGCSSPPPPEPSPQAPDGPSLQLPAQTFSSAPVPGSSSSTLPSS-----CEQSRQAETP 704

  Fly   822 SKRETEMNQNIEDVA--LLLQNLASMSS 847
            |..:|| ..:..||:  |.||:|.:.|:
Human   705 SDPQTE-TLSAMDVSEFLSLQSLDTPSN 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	100/143 (70%)
		C2H2 Zn finger	331..353	CDD:275368	14/21 (67%)
		zf-H2C2_2	345..372	CDD:290200	17/26 (65%)
		C2H2 Zn finger	361..383	CDD:275368	16/21 (76%)
		zf-H2C2_2	375..402	CDD:290200	20/26 (77%)
		C2H2 Zn finger	391..413	CDD:275368	15/21 (71%)
		zf-C2H2	418..440	CDD:278523	16/23 (70%)
		C2H2 Zn finger	420..440	CDD:275368	14/21 (67%)
		zf-H2C2_2	432..458	CDD:290200	16/25 (64%)
		COG5048	442..>519	CDD:227381	41/76 (54%)
		C2H2 Zn finger	448..470	CDD:275368	16/21 (76%)
		zf-H2C2_2	462..489	CDD:290200	16/26 (62%)
		C2H2 Zn finger	478..500	CDD:275368	12/21 (57%)
		DUF3682	862..>931	CDD:289231
MTF1	NP_005946.2	COG5048	<93..291	CDD:227381	114/197 (58%)
		Nuclear localization signal. /evidence=ECO:0000255	133..138		0/4 (0%)
		C2H2 Zn finger	145..164	CDD:275368	13/18 (72%)
		zf-H2C2_2	156..183	CDD:290200	17/26 (65%)
		C2H2 Zn finger	172..194	CDD:275368	16/21 (76%)
		zf-H2C2_2	186..213	CDD:290200	20/26 (77%)
		C2H2 Zn finger	202..224	CDD:275368	15/21 (71%)
		zf-C2H2_8	231..319	CDD:292531	57/91 (63%)
		C2H2 Zn finger	234..253	CDD:275368	12/18 (67%)
		zf-H2C2_2	245..271	CDD:290200	16/25 (64%)
		C2H2 Zn finger	261..283	CDD:275368	16/21 (76%)
		zf-H2C2_2	275..302	CDD:290200	16/26 (62%)
		C2H2 Zn finger	291..313	CDD:275368	12/21 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..328		10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..466		5/70 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	648..715		13/72 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149883
Domainoid	1	1.000	47	1.000	Domainoid score	I12058
eggNOG	1	0.900	-	-		E33208_3BK16
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008189
OrthoInspector	1	1.000	-	-		oto88370
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5629
SonicParanoid	1	1.000	-	-		X6153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.730