DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTF-1 and Phs

DIOPT Version :9

Sequence 1:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_648789.3	Gene:	Phs / 39697	FlyBaseID:	FBgn0036522	Length:	971	Species:	Drosophila melanogaster

Alignment Length:	723	Identity:	161/723 - (22%)
Similarity:	254/723 - (35%)	Gaps:	235/723 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SLSDSRD----YDTNSSRNSLSGSPPV--------TSNCSSSGSLDFDRPL-------------- 68
            ||.|.:|    .|.....|...|..||        |||.:.:|:...:..:
  Fly   365 SLRDEQDNAEKTDKKKKLNKEEGQQPVLEPLQAKKTSNQAENGATQSNNVVKVQQNAKGSKKDGT 429

  Fly    69 --AQLLE--PKLEADGLGIIHGDNYSIYGSQTAESTSGEQQVLNLGLTLDTGDAQATYGDLFGAQ 129
              ||..|  ||         |.:|.........||.:.::.:.:..||:|......|..|....|
  Fly   430 QSAQKSETNPK---------HLENAETNSKDNTESVALKETIHDKQLTIDEAGKAGTQKDDNSNQ 485

  Fly   130 DQLTASQTHG---------HSQVVVSAAADNAFSLADQLTPLPITVIPITYHHTTE---NLSSSH 182
            .||..|:.:.         |.|:.|.:|.|:     .|:|..|.        ::|:   ......
  Fly   486 KQLDKSEANAGKSKMVDQVHQQMPVESAKDH-----QQMTEEPT--------NSTKRKRGRKERK 537

  Fly   183 SEVPLIASLSDITAQVFNLDDICFTLEYQFENQRLVQVQPPTVVSLSMVSSPNEAANPPINCDND 247
            |..|::..|.|...:.          |.:...:|:
  Fly   538 SPTPVLIPLGDKEIKE----------EPELPERRM------------------------------ 562

  Fly   248 QGTGNSISRDSTSNSPAYFTIETSYVDEYDPNEPDEDEQLAHCIQPGVLHQDVDEEEVE------ 306
                    |.|..:        ..||.|....|.|:||              |:|.||:
  Fly   563 --------RKSRQH--------VDYVVEIKDEEEDDDE--------------VEEAEVDDDSSAT 597

  Fly   307 ----RQDENDQLMALAYESSDEALSR-----YRCNYENCYRSYSTIGNLRTHLKTHTGDYSFKCP 362
                ....::...::..|||:|:...     :.||:  |.:::.....::.||:.|||:..:.|.
  Fly   598 ISPHNSSTDESFTSIKRESSEESQHNGIGGIHTCNF--CGKTFKRFSRMQDHLRLHTGEKPYVCG 660

  Fly   363 EDGCHKAFLTSYSLKIHVRVHTKVKPYECEVSGCDKAFNTRYRLHAHLRLH-NGETFNCELCQKC 426
            :  |.:||.....|..|...|...|.|:|::  |.....|:..|..|:|.| |...:.|:.|.|.
  Fly   661 Q--CGRAFRLKMRLVEHQLRHRAEKAYKCDI--CSMPLATKQDLSLHMRHHKNDRRYKCDKCNKG 721

  Fly   427 FTTLSDLKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTHRRT---------------------- 469
            |...|||..|:|.||.|:||.|  |.|||||.|..:|..||||
  Fly   722 FVRSSDLSIHVRIHTGEKPYSC--DLCGKAFRARQNLVVHRRTHLGDKPIQCELCDKRFARKIDM 784

  Fly   470 ------HTGEKPYPCQEDSCQKSFSTSHSLKSH-KKTHQRQLQNKGRKKRPLKTQQTKCSDQEQK 527
                  |||||||.|  |:||:.:|:..:|..| ::.|..:.|..|..:...|..:|...::::.
  Fly   785 RVHMRRHTGEKPYNC--DACQRGYSSRVNLLRHQEREHGIEEQVPGSGQADKKHTKTATENEQEN 847

  Fly   528 DPQQEEQEEEEFIKEDQPEMTLLNPGSHCSETTSTDSGVVLQTLTPQDHLSNVFILQGNEPLILP 592
            :|:.:....       :|....|.                 |.:..|:.|.|......:....:|
  Fly   848 EPKAKAAPR-------RPRREKLQ-----------------QKIAAQEKLLNDLKRSLSAMPEIP 888

  Fly   593 ETSQAYQLSYAAEEEIPSPWIDAG-------VLVSKPIIPMAPLTDACVALPTEMPSFVNLKPTF 650
            |.|...:|. .:.::||:   |||       |.:|..:.| ||.|:          ....:.|..
  Fly   889 EESAQVKLD-GSGQDIPA---DAGAGHAQVQVTLSMQMEP-APNTE----------DDEEITPEK 938

  Fly   651 GNAVSGNM 658
            .||:|.:|
  Fly   939 ENALSSSM 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	52/170 (31%)
		C2H2 Zn finger	331..353	CDD:275368	5/21 (24%)
		zf-H2C2_2	345..372	CDD:290200	9/26 (35%)
		C2H2 Zn finger	361..383	CDD:275368	6/21 (29%)
		zf-H2C2_2	375..402	CDD:290200	7/26 (27%)
		C2H2 Zn finger	391..413	CDD:275368	6/21 (29%)
		zf-C2H2	418..440	CDD:278523	9/21 (43%)
		C2H2 Zn finger	420..440	CDD:275368	9/19 (47%)
		zf-H2C2_2	432..458	CDD:290200	15/25 (60%)
		COG5048	442..>519	CDD:227381	34/105 (32%)
		C2H2 Zn finger	448..470	CDD:275368	13/49 (27%)
		zf-H2C2_2	462..489	CDD:290200	16/54 (30%)
		C2H2 Zn finger	478..500	CDD:275368	7/22 (32%)
		DUF3682	862..>931	CDD:289231
Phs	NP_648789.3	COG5048	<594..787	CDD:227381	56/200 (28%)
		C2H2 Zn finger	631..651	CDD:275368	5/21 (24%)
		zf-H2C2_2	644..666	CDD:290200	7/23 (30%)
		zf-H2C2_2	699..724	CDD:290200	9/24 (38%)
		zf-C2H2	713..735	CDD:278523	9/21 (43%)
		C2H2 Zn finger	715..735	CDD:275368	9/19 (47%)
		zf-H2C2_2	727..750	CDD:290200	14/24 (58%)
		C2H2 Zn finger	743..763	CDD:275368	12/21 (57%)
		zf-H2C2_2	755..780	CDD:290200	5/24 (21%)
		C2H2 Zn finger	771..791	CDD:275368	0/19 (0%)
		zf-H2C2_2	783..808	CDD:290200	11/26 (42%)
		C2H2 Zn finger	799..816	CDD:275370	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24377
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010