DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTF-1 and zld

DIOPT Version :9

Sequence 1:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_001285466.1	Gene:	zld / 32994	FlyBaseID:	FBgn0259789	Length:	1596	Species:	Drosophila melanogaster

Alignment Length:	865	Identity:	184/865 - (21%)
Similarity:	276/865 - (31%)	Gaps:	280/865 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNDQEK------QHQQQQQHY------FHSEWKTTANSHGNSLSDSRDYDTNSSRNSLSGSPPVT 53
            :.|||:      ||||..|.|      :||       |..|:||.|   :||.|..| |.||...
  Fly   866 LRDQEQADDHLHQHQQASQQYLLSARHYHS-------STPNTLSSS---NTNPSTPS-SNSPHTI 919

  Fly    54 SNCSSSGSLDFDR--PLAQLLEPKLEADGLGII--HGDNYSIYG------------SQTAESTSG 102
            ......|: ||.|  |..|.|.|      :|::  ...:|::..            |...:.:|.
  Fly   920 YRQEQQGT-DFSRTTPPPQPLPP------MGMLPPMAMDYNMLALDMPMPMPTLMHSNMLQCSST 977

  Fly   103 EQQVLNLGLTLDTGDA------------QATYGDL---FGAQDQLTASQTHGHS----QVVVSAA 148
            ....|...:|....|.            ||....|   .|.|.|...:..|...    |:.....
  Fly   978 STTPLATTITTSMPDTMQPPQQQLVHHYQAVLHPLHQQLGEQHQRQEADHHQQQRELHQLDQQQQ 1042

  Fly   149 ADNAFSLADQL---------------TPLPITVI---------PITYHHTTENLSSSHSEVPLIA 189
            ...|..|||.|               .|:|:|.|         |...|.|:.........:|::.
  Fly  1043 QQQALILADSLPHSSSSPTSSSPPPTMPMPLTTITAPQLLPLQPPPPHITSTMPMPPTMHMPIMP 1107

  Fly   190 SLSDITAQVFNLDDICFTLEYQ-----------------FENQ------RLVQVQPPTV------ 225
            .......|:..||.   |:.|.                 :.||      :::|:.|.::
  Fly  1108 PPPQCYQQLQPLDP---TMSYHTIIGSGPEAHTGTAGGGYSNQITTSDGQILQLMPTSLFAPYAP 1169

  Fly   226 ---VSLSMVSSPNEAANPPINCDNDQGTGNSISRDSTSNSPAYFTIETSYVDEYDPNE--PDEDE 285
               .|::...||.|...||::........:.......:.:|....:.|.|......:.  |..:.
  Fly  1170 LSPYSVAAQRSPQEGDLPPVHTLTTALHAHQQGGQQEAQTPTLTVLSTPYSPTVSSSRATPALEM 1234

  Fly   286 QLAHCIQPGVLHQDVDEEEVERQ--------------DENDQLMALAYES---SDEALSRYR--- 330
            .:|..:|.   |||.:.|:.:.|              |...|...||.::   :.:.|::.|
  Fly  1235 DMATLMQH---HQDYEMEQYQMQHQQLDQMQQHQQQLDHQQQQQILADQTQTMAQQPLAKKRRGG 1296

  Fly   331 --CNYENCYRSYSTIGNLRTHLKTHTGDYSFKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYECEV 393
              .......|..|::|:...| .|.......||.|
  Fly  1297 NATPSTTKRRRNSSVGSTSPH-STTLPSGRIKCLE------------------------------ 1330

  Fly   394 SGCDKAFNTRYRLHAHLR-LHNGE-TFNCELCQKCFTTLSDLKKHMRTH-TQERPYKCPEDDCGK 455
              |||.|.....|..|.: .|:|| .|.|:.|.|.|.:......|:..| ||::|:||  :.|.|
  Fly  1331 --CDKEFTKNCYLTQHNKSFHSGEYPFRCQKCGKRFQSEDVYTTHLGRHRTQDKPHKC--ELCPK 1391

  Fly   456 AFTASHHLKTHRR----THTGEKPYPCQEDSCQKSFSTSHSLKSHKKTHQRQLQNKGRKKRPLKT 516
            .|   ||....||    .|||.|.:.|  |.|:|.|.....|:.|.:||.|
  Fly  1392 QF---HHKTDLRRHVEAIHTGLKQHMC--DICEKGFCRKDHLRKHLETHNR-------------- 1437

  Fly   517 QQTKCSDQEQKDPQQEEQEEEEFIKEDQPEMTLLNPGSHCSETTSTDSGVVLQTLTPQDHLSNVF 581
                                        |.:.    |...:...:..:.....|.|..
  Fly  1438 ----------------------------PRVV----GKKSAAAAAAAAAAAAVTATAG------- 1463

  Fly   582 ILQGNEPLILPETSQAYQLSYAAEEEIPSPWIDAGVLVSKPIIPMAPLTDACVALPTEMPSF--- 643
             |.|.......:.:.|..|:..|....|.    |||     .||.||.|..|..:.....:.
  Fly  1464 -LGGAPAAGSIKAAFARSLTVTAVSSEPG----AGV-----AIPSAPATATCAPVSVSASALVQA 1518

  Fly   644 VNLKPTFGNAVSGNMGDPQPETMDVDPTVETSLPTPTLELNQPNIEELLKQDSFENEEDMETESL 708
            ||...|.|.::..::.|     :.||   :.||    ||.::..:|..::.|..|.|::.|.|
  Fly  1519 VNPSLTSGLSLKRHIDD-----VAVD---DDSL----LEEDEDEMEMEMEMDMLEEEDEEEEE-- 1569

  Fly   709 LNDILMTIDNNSALLQATLQ 728
            |.|..|.|  .|..:|...|
  Fly  1570 LGDHHMII--KSEYVQEEFQ 1587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	37/153 (24%)
		C2H2 Zn finger	331..353	CDD:275368	4/21 (19%)
		zf-H2C2_2	345..372	CDD:290200	5/26 (19%)
		C2H2 Zn finger	361..383	CDD:275368	2/21 (10%)
		zf-H2C2_2	375..402	CDD:290200	4/26 (15%)
		C2H2 Zn finger	391..413	CDD:275368	6/22 (27%)
		zf-C2H2	418..440	CDD:278523	6/21 (29%)
		C2H2 Zn finger	420..440	CDD:275368	5/19 (26%)
		zf-H2C2_2	432..458	CDD:290200	9/26 (35%)
		COG5048	442..>519	CDD:227381	25/80 (31%)
		C2H2 Zn finger	448..470	CDD:275368	8/25 (32%)
		zf-H2C2_2	462..489	CDD:290200	12/30 (40%)
		C2H2 Zn finger	478..500	CDD:275368	7/21 (33%)
		DUF3682	862..>931	CDD:289231
zld	NP_001285466.1	zf-C2H2_jaz	552..577	CDD:288983
		LIM	1328..1389	CDD:259829	23/94 (24%)
		C2H2 Zn finger	1328..1349	CDD:275368	8/52 (15%)
		C2H2 Zn finger	1357..1377	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1386..1407	CDD:275368	8/25 (32%)
		zf-H2C2_2	1398..1422	CDD:290200	10/25 (40%)
		zf-C2H2	1413..1435	CDD:278523	7/23 (30%)
		C2H2 Zn finger	1415..1435	CDD:275368	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457143
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930