DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MTF-1 and CG42726

DIOPT Version :9

Sequence 1:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_732017.3	Gene:	CG42726 / 318709	FlyBaseID:	FBgn0261679	Length:	441	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	113/507 - (22%)
Similarity:	186/507 - (36%)	Gaps:	156/507 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 PPINCDNDQGTG-NSISRDSTSNSPAYFTIETSYVD--------EYDPNEPDE-------DEQLA 288
            |..|||   .|| |.:..||..::.....:.....|        ..|..|..|       |:::.
  Fly     5 PRCNCD---ATGQNRLVTDSCGHTKCRLCLVADVSDCLECRVARSVDIQETQETQARTSADKRII 66

  Fly   289 ------HCIQPGVLHQDVDEEEVERQDENDQLMALAYESSDEALSRYRCNYENCYRSYSTIGNLR 347
                  ||.   |.::|.       :....|...|.  ..::.|.::.|  :.|.|.::|..:|:
  Fly    67 VTDKGYHCT---VCNKDF-------RSRTQQYYHLT--CGNDLLKKFNC--KECGRRFATSSHLK 117

  Fly   348 THLKTHTGDYSFKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYECEVSGCDKAFNTRYRLHAHLRL 412
            .||.:|.......|  ..|||:|.....|:.|:..|.:.| :.|.:  |.|.|..:..|.:||.:
  Fly   118 YHLMSHEKQSKHSC--SVCHKSFKQPIVLQRHMLTHNQEK-HLCPI--CQKVFRRKSSLASHLAI 177

  Fly   413 HN--GETFNCELCQKCFTTLSDLKKHMRTHTQER-PYKCPEDDCGKAFTASHHLKTHRRTHTGEK 474
            |:  |..|.||||.|.|...::|.:|:|.|.:.. .:.|..  |.|:|.....|:.|.:.|:..:
  Fly   178 HSDLGLQFKCELCSKHFQNKANLNQHLRKHDKNNIRHMCKV--CQKSFLRQTTLRLHMKRHSNRE 240

  Fly   475 PYPCQEDSCQKSFSTSHSLKSHKKTHQR-----------QLQNKGRKKRPLKTQQTKC---SDQE 525
            ...|  ..|.||::...:|..|.:.|:.           .:..|....|.|::....|   |..|
  Fly   241 RQSC--SLCGKSYNDPDALGRHLRQHKTAERYRCIQCDITINRKDNMLRHLRSMHPGCAFASTVE 303

  Fly   526 QKDPQQEEQEEEEFIKEDQPEMTLLNPGSHCSETTSTDSGVVLQTLTPQDHLSNVFILQGN-EPL 589
            ...|:...||..  ..|::|           |:|...:|  |:|::             || ||:
  Fly   304 MVTPRSSAQEAT--TAEERP-----------SQTVRYNS--VIQSV-------------GNVEPV 340

  Fly   590 ILPETSQAYQLSYAAEEEIPSPWIDAGVLVSKPIIPMAPLTDACVALPTEMPSFVNLKPTFGNAV 654
            :|                          |.|.|             ||:::|   .|:...|.||
  Fly   341 ML--------------------------LQSTP-------------LPSQLP---ELQMEKGKAV 363

  Fly   655 SGNMGDPQPETM-------------DVDPTVETSLPT-----PTLELNQPNI 688
            ..::  |.|:.|             |:|....:|.|:     |.::.:||.:
  Fly   364 PEHL--PLPDVMPEENVQLYRKIILDLDNEEYSSEPSPDAQEPAMQHHQPRV 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	43/144 (30%)
		C2H2 Zn finger	331..353	CDD:275368	7/21 (33%)
		zf-H2C2_2	345..372	CDD:290200	9/26 (35%)
		C2H2 Zn finger	361..383	CDD:275368	7/21 (33%)
		zf-H2C2_2	375..402	CDD:290200	8/26 (31%)
		C2H2 Zn finger	391..413	CDD:275368	7/21 (33%)
		zf-C2H2	418..440	CDD:278523	10/21 (48%)
		C2H2 Zn finger	420..440	CDD:275368	9/19 (47%)
		zf-H2C2_2	432..458	CDD:290200	7/26 (27%)
		COG5048	442..>519	CDD:227381	17/88 (19%)
		C2H2 Zn finger	448..470	CDD:275368	6/21 (29%)
		zf-H2C2_2	462..489	CDD:290200	7/26 (27%)
		C2H2 Zn finger	478..500	CDD:275368	6/21 (29%)
		DUF3682	862..>931	CDD:289231
CG42726	NP_732017.3	C2H2 Zn finger	74..94	CDD:275368	5/31 (16%)
		C2H2 Zn finger	103..123	CDD:275368	7/21 (33%)
		COG5048	<112..288	CDD:227381	49/184 (27%)
		C2H2 Zn finger	131..151	CDD:275368	7/21 (33%)
		Chordopox_A33R	151..>254	CDD:283591	33/109 (30%)
		C2H2 Zn finger	158..178	CDD:275368	7/21 (33%)
		C2H2 Zn finger	187..207	CDD:275368	9/19 (47%)
		C2H2 Zn finger	216..236	CDD:275368	6/21 (29%)
		C2H2 Zn finger	244..264	CDD:275368	6/21 (29%)
		C2H2 Zn finger	272..290	CDD:275368	2/17 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840