DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTF-1 and mtf1

DIOPT Version :9

Sequence 1:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	XP_021322285.1	Gene:	mtf1 / 195821	ZFINID:	ZDB-GENE-020424-1	Length:	749	Species:	Danio rerio

Alignment Length:	751	Identity:	226/751 - (30%)
Similarity:	313/751 - (41%)	Gaps:	207/751 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 NCDNDQGTGNSISRDSTSNSPAYFTIETSYVDEYDPNEPDEDEQ----------------LAHCI 291
            |.|.|   ||.||..|:|:...|  ..|:.:.|.||...||:.:                ||...
Zfish    63 NFDKD---GNMISGPSSSSGTVY--DRTTVLIEQDPIRLDEEGEEDGMTFLPEGEGDEGSLAFMG 122

  Fly   292 QP-----GVLHQDVDEEEVE-----------RQDENDQLM--ALAYESSDEALSRYRCNYENCYR 338
            .|     |.:|..:..::::           |..|...|.  :...|:....:.||:|.:|.|.|
Zfish   123 DPDGMSQGYIHHTISPDQIQFIINPGSTPMPRNIEGATLTLHSECPETKQREVKRYQCLFEGCTR 187

  Fly   339 SYSTIGNLRTHLKTHTGDYSFKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYECEVSGCDKAFNTR 403
            :|||.||||||.|||.|:|:|.|.:.||.||||||||||||||||||.||:||:|.||:|||||.
Zfish   188 TYSTAGNLRTHQKTHRGEYTFVCNQQGCGKAFLTSYSLKIHVRVHTKEKPFECDVQGCEKAFNTL 252

  Fly   404 YRLHAHLRLHNGETFNCEL--CQKCFTTLSDLKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTH 466
            |||.||.|||.|:|||||.  |.|.|||||||:||:||||.|:|::|..|.|||||.||||||||
Zfish   253 YRLKAHQRLHTGKTFNCESEGCTKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTH 317

  Fly   467 RRTHTGEKPYPCQEDSCQKSFSTSHSLKSHKKTHQR----------------------------- 502
            .||||||||:.|..|.|:|:||:.:|||||.:.|.:
Zfish   318 VRTHTGEKPFFCPSDGCEKTFSSQYSLKSHIRGHDKGPSFTVSSHPLSEDANHSLCLSDLSLIST 382

  Fly   503 --QLQNKGRKK-------RPLKTQQTKCSDQE----QKDPQQEEQEEEEFIKEDQPEMTLLNPGS 554
              :||.....:       .|::..:......|    :.||:..|...|.|..|..|:....:..:
Zfish   383 DSELQENHNSQGLDLNSVTPIRIFELMFQSPENSVSEDDPKPTESLAESFGLEPSPQTAPADAST 447

  Fly   555 H----------CSETTSTDSGVVLQTLTPQDHLSNVFILQGNEPLILPETSQAYQLSYAAEEEIP 609
            |          ||.:.|.       |...||         ...|   |.|.||...:.::..:..
Zfish   448 HPAFPQPPPSTCSSSCSI-------TAPAQD---------AQTP---PTTQQAPPPAVSSSSQTS 493

  Fly   610 S-----PWIDAGVLVSKPIIPMAPLTDACVALPTEMPSFVNLKPTFGN------AVSGNMGDPQP 663
            |     |.......||.|..|.| .....:|.|...||..::......      ||:..:....|
Zfish   494 SFPSAPPSSSQPAEVSSPSAPSA-TQHYMMAQPVSSPSAASVSSVPAGTAEVTAAVTHTVPLAAP 557

  Fly   664 ETMDVDPTVETSLPTPTLELNQPNIEELLKQ--DSFENEEDM--ETESLLNDILMTIDNNSALLQ 724
            .|:.:.||:...   |:|.::..|::.:|..  .:.:|.|..  :.|.:.....:.:..||.
Zfish   558 PTISIAPTLGLQ---PSLVMSDQNLQWILSSAASAQQNPEQQGPKVEKVFFTTAIPVGGNSG--- 616

  Fly   725 ATLQQASQVPSDASGLVELDIRDNKPTLKQITADAGICNCTNCKC-DQTKSCHGGDCGAAAAQQT 788
            ..:||.        ||       :.|.:  |......|.| :|.| |..|     |...:::|..
Zfish   617 NAVQQI--------GL-------SLPVI--IIKQEESCQC-HCACRDSAK-----DKSTSSSQDK 658

  Fly   789 TRTGAP-------------------------------TTTTTTTTMNSSGGKRICGSVVPTKKVS 822
            |:..:|                               ...|...|.|.           ||..:.
Zfish   659 TKNTSPPPPPAPPPPPPALPKEPPSCCPSKPHTQPQQDLPTAPLTPNP-----------PTDALG 712

  Fly   823 KRET------EMNQNIEDVALLLQNLASMSSGGSSG 852
            ..:.      |...||| ..|::.:..||:.||.||
Zfish   713 SMDVSDLLSPETTANIE-ALLMVADGFSMADGGGSG 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	101/143 (71%)
		C2H2 Zn finger	331..353	CDD:275368	14/21 (67%)
		zf-H2C2_2	345..372	CDD:290200	17/26 (65%)
		C2H2 Zn finger	361..383	CDD:275368	17/21 (81%)
		zf-H2C2_2	375..402	CDD:290200	21/26 (81%)
		C2H2 Zn finger	391..413	CDD:275368	15/21 (71%)
		zf-C2H2	418..440	CDD:278523	16/23 (70%)
		C2H2 Zn finger	420..440	CDD:275368	14/21 (67%)
		zf-H2C2_2	432..458	CDD:290200	16/25 (64%)
		COG5048	442..>519	CDD:227381	40/114 (35%)
		C2H2 Zn finger	448..470	CDD:275368	16/21 (76%)
		zf-H2C2_2	462..489	CDD:290200	18/26 (69%)
		C2H2 Zn finger	478..500	CDD:275368	11/21 (52%)
		DUF3682	862..>931	CDD:289231
mtf1	XP_021322285.1	C2H2 Zn finger	183..202	CDD:275368	13/18 (72%)
		COG5048	<185..349	CDD:227381	115/163 (71%)
		C2H2 Zn finger	210..232	CDD:275368	17/21 (81%)
		C2H2 Zn finger	240..262	CDD:275368	15/21 (71%)
		C2H2 Zn finger	272..291	CDD:275368	12/18 (67%)
		C2H2 Zn finger	299..321	CDD:275368	16/21 (76%)
		COG5048	302..>431	CDD:227381	41/128 (32%)
		C2H2 Zn finger	329..351	CDD:275368	11/21 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584023
Domainoid	1	1.000	47	1.000	Domainoid score	I12067
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008189
OrthoInspector	1	1.000	-	-		oto41436
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.930