DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MTF-1 and Mtf1

DIOPT Version :9

Sequence 1:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_032662.3	Gene:	Mtf1 / 17764	MGIID:	101786	Length:	675	Species:	Mus musculus

Alignment Length:	648	Identity:	209/648 - (32%)
Similarity:	291/648 - (44%)	Gaps:	165/648 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 DNDQGTGNSISRDSTSNSPAYFTIETS---YVDEYDPNEPDEDEQLAHCIQPGVLHQDVD--EEE 304
            :.|.||......|.....|..|.:|..   .:|:    |......:.|.|.|..:|..::  ...
Mouse    52 EQDPGTLEDDEDDGQCGEPLPFLVEGEEGFLIDQ----EAMSQGYVQHIISPDQIHLTINPGSTP 112

  Fly   305 VERQDEND--QLMALAYESSDEALSRYRCNYENCYRSYSTIGNLRTHLKTHTGDYSFKCPEDGCH 367
            :.|..|..  .|.:...|:..:.:.||:|.:|.|.|:|||.||||||.|||.|:|:|.|.::||.
Mouse   113 MPRNIEGATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCG 177

  Fly   368 KAFLTSYSLKIHVRVHTKVKPYECEVSGCDKAFNTRYRLHAHLRLHNGETFNCEL--CQKCFTTL 430
            |||||||||:||||||||.||:||:|.||:|||||.|||.||.|||.|:|||||.  |.|.||||
Mouse   178 KAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESQGCSKYFTTL 242

  Fly   431 SDLKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFSTSHSLKS 495
            |||:||:||||.|:|::|..|.|||||.||||||||.||||||:|:.|..:.|:|:|||.:||||
Mouse   243 SDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKS 307

  Fly   496 HKKTHQRQLQNKGRKKRPLKTQQTKCSDQEQKDPQQEEQEEEE---FIKEDQPEMTLLNPGSHCS 557
            |.|.|    .|||.....|              ||....|:..   ::.    |:.||:..|...
Mouse   308 HMKGH----DNKGTAYSAL--------------PQHNGSEDTNHSLYLS----ELGLLSTDSELQ 350

  Fly   558 ETTSTDSGVVLQTLTP----------------QD------------------------------H 576
            |.:|:.....|.|::|                ||                              .
Mouse   351 ENSSSTQDQDLSTISPAIIFESMFQNSDDPGIQDDPLQTAALIDSFNGDAESVIDVPPPAGNSAS 415

  Fly   577 LSNVFILQ----------------------------------GNEPLIL--PETSQAYQLSYAA- 604
            ||...:||                                  |:.|.:|  ||....:...:||
Mouse   416 LSLPLVLQSGISEPPQPLLPATAPSAPPPAPSLGPGSQPAAFGSPPALLQPPEVPVPHSTQFAAN 480

  Fly   605 -EEEIPSPWIDAGVLV-SKPIIPMAPLTDA----CVALP------TE-MPSFVNLKPTFGNAVSG 656
             :|.:|.|......:| ...::..||.:.|    .||.|      || :|:.|...|...|:|..
Mouse   481 HQEFLPHPQAPPQTIVPGLSVVAGAPASAATVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLT 545

  Fly   657 NMGDPQPETMDVDPTVETSLPTPTLELNQPNIEELLK--QDSFENEEDMETESLLNDILMTIDNN 719
            |  :|   |:.:.||..|::...:|.:.:.|::.:|.  ..|.:|:|.::..|.:..:..
Mouse   546 N--NP---TITITPTPNTAILQSSLVMGEQNLQWILNGATSSPQNQEQIQQASKVEQVYF----- 600

  Fly   720 SALLQATLQQASQVP---SDASGLVELDIRDNKPTLKQITADAGICNCTNCKC-DQTKSCHGG 778
                      |:.||   ...|.:.::.:......:||..|    |.| .|.| |..|....|
Mouse   601 ----------ATAVPVASGTGSSVQQIGLSVPVIIIKQEEA----CQC-QCACRDSAKERAAG 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	100/143 (70%)
		C2H2 Zn finger	331..353	CDD:275368	14/21 (67%)
		zf-H2C2_2	345..372	CDD:290200	17/26 (65%)
		C2H2 Zn finger	361..383	CDD:275368	16/21 (76%)
		zf-H2C2_2	375..402	CDD:290200	20/26 (77%)
		C2H2 Zn finger	391..413	CDD:275368	15/21 (71%)
		zf-C2H2	418..440	CDD:278523	16/23 (70%)
		C2H2 Zn finger	420..440	CDD:275368	14/21 (67%)
		zf-H2C2_2	432..458	CDD:290200	16/25 (64%)
		COG5048	442..>519	CDD:227381	41/76 (54%)
		C2H2 Zn finger	448..470	CDD:275368	16/21 (76%)
		zf-H2C2_2	462..489	CDD:290200	16/26 (62%)
		C2H2 Zn finger	478..500	CDD:275368	12/21 (57%)
		DUF3682	862..>931	CDD:289231
Mtf1	NP_032662.3	COG5048	<92..308	CDD:227381	123/215 (57%)
		Nuclear localization signal. /evidence=ECO:0000255	132..137		0/4 (0%)
		C2H2 Zn finger	141..163	CDD:275368	14/21 (67%)
		zf-H2C2_2	155..182	CDD:290200	17/26 (65%)
		C2H2 Zn finger	171..193	CDD:275368	16/21 (76%)
		zf-H2C2_2	185..212	CDD:290200	20/26 (77%)
		C2H2 Zn finger	201..223	CDD:275368	15/21 (71%)
		C2H2 Zn finger	235..252	CDD:275368	12/16 (75%)
		zf-H2C2_2	244..270	CDD:290200	16/25 (64%)
		C2H2 Zn finger	260..282	CDD:275368	16/21 (76%)
		zf-H2C2_2	274..301	CDD:290200	16/26 (62%)
		C2H2 Zn finger	290..312	CDD:275368	12/21 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	427..464		2/36 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..675		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839928
Domainoid	1	1.000	47	1.000	Domainoid score	I11975
eggNOG	1	0.900	-	-		E33208_3BK16
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3890
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008189
OrthoInspector	1	1.000	-	-		oto91941
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5629
SonicParanoid	1	1.000	-	-		X6153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.810