DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTF-1 and blmp-1

DIOPT Version :9

Sequence 1:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_001251370.1	Gene:	blmp-1 / 172917	WormBaseID:	WBGene00003847	Length:	817	Species:	Caenorhabditis elegans

Alignment Length:	627	Identity:	142/627 - (22%)
Similarity:	229/627 - (36%)	Gaps:	188/627 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 YFHSEWKTTANSHGNSLSDSRDYDTN---SSRNSLSGSPPVTSNCSSSGSLDFDRPLAQLLEPKL 76
            ||::..|..||:. .|...||||...   |:|..:....|.|....|:........:|.|.|..:
Worm   223 YFYTVKKIEANTE-LSFWFSRDYARKLNYSTRPYVRVRRPATQLIPSAPPASASTAIASLAETIV 286

  Fly    77 EADGLGIIHGDNYSIYGSQTAESTSGEQQVLNLGLTLDTGDAQATYGDLFGAQDQLT-------- 133
            ..|         ||:  .:..||...         ||.|..:.|:..::...::|.:
Worm   287 AID---------YSV--KKLIESPID---------TLSTDASSASDEEMIDVEEQESCTRPVAEV 331

  Fly   134 --------------ASQTHGHSQVVVSAAADNAFSLAD---------QL---------TPLPITV 166
                          |::.:....:.|......|..|.|         ||         :|:..|.
Worm   332 TRPNVIQNPVVRPVATKVNNFPGIPVRLGNFYASPLVDFKEFMRKSLQLKLVDTSMFVSPVAQTT 396

  Fly   167 IPITYHHTTENLSSSHSEV-PLIASLSDITAQVFNLDDICFTLEYQFENQRLVQVQPPTVVSLSM 230
            ..||   .|...|....:| |::|:.:.  |...|...|..:.::|.|            :|..:
Worm   397 AAIT---ATGGRSGQPIDVQPVLAATAG--AHFGNYAAIYGSQDFQHE------------LSKPL 444

  Fly   231 VSSPNEAANPPINCDNDQGTGNS-----------ISRDSTSNSPAYFTIETSYVDEYDPNEPDED 284
            .:|.:.|...........|.|.|           ::..|:|::.:.|....:||
Worm   445 YTSASPAFGGGGGMGGGFGMGGSAHTSSFHQLPFVNHSSSSHNDSSFNGVPNYV----------- 498

  Fly   285 EQLAHCIQPGVLHQDVDEEEVERQDENDQLMALAYESSDEALSRYRCNYENCYRSYSTIGNLRTH 349
                                  :|.||.:             :||.|  ::|.:::..:.||:.|
Worm   499 ----------------------QQQENGK-------------TRYAC--KDCNKTFGQLSNLKVH 526

  Fly   350 LKTHTGDYSFKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYECEVSGCDKAFNTRYRLHAHLRLHN 414
            ::||||:..|||  :.|.|.|.....|:.|..|||..:|:.|::  |||.|::...|..||||||
Worm   527 VRTHTGERPFKC--EICTKEFTQLAHLQKHHLVHTGERPHRCDI--CDKRFSSTSNLKTHLRLHN 587

  Fly   415 GE-TFNCELCQKCFTTLSDLKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTHRRTHTGEKPYPC 478
            |: .:.|::|...||....|:.|.|.|..||||.|  ..|||.:.:...|:||.:|.|      |
Worm   588 GQKPYTCDVCDAKFTQYVHLRLHKRLHANERPYSC--GTCGKKYISPSGLRTHWKTTT------C 644

  Fly   479 QEDSCQKSF--------------STSHSLKSHKKTHQRQLQNKGRKKRPLKTQQTKCSD------ 523
            :|:..:.|.              |.|.|...:....:..|.::  .||||...:|..|.
Worm   645 KEEDMKDSMRDDLMDIKGEIDEGSMSGSGYGNLGIFENTLNSE--LKRPLMPIETIYSKYNLPNA 707

  Fly   524 ----------QEQKDPQQEEQEEEEFIKEDQPEMTLLNPGSH 555
                      |||:.|....|:::..:..:  .|..:..|||
Worm   708 SLLGQGPSGMQEQQAPPPTSQQQQHMMYGN--TMGHMGQGSH 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	55/142 (39%)
		C2H2 Zn finger	331..353	CDD:275368	5/21 (24%)
		zf-H2C2_2	345..372	CDD:290200	13/26 (50%)
		C2H2 Zn finger	361..383	CDD:275368	6/21 (29%)
		zf-H2C2_2	375..402	CDD:290200	11/26 (42%)
		C2H2 Zn finger	391..413	CDD:275368	9/21 (43%)
		zf-C2H2	418..440	CDD:278523	7/21 (33%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..458	CDD:290200	12/25 (48%)
		COG5048	442..>519	CDD:227381	24/90 (27%)
		C2H2 Zn finger	448..470	CDD:275368	7/21 (33%)
		zf-H2C2_2	462..489	CDD:290200	8/40 (20%)
		C2H2 Zn finger	478..500	CDD:275368	6/35 (17%)
		DUF3682	862..>931	CDD:289231
blmp-1	NP_001251370.1	SET	119..247	CDD:214614	10/24 (42%)
		zf-C2H2	508..530	CDD:278523	6/23 (26%)
		C2H2 Zn finger	510..530	CDD:275368	5/21 (24%)
		zf-H2C2_2	522..547	CDD:290200	13/26 (50%)
		C2H2 Zn finger	538..558	CDD:275368	6/21 (29%)
		zf-H2C2_2	550..575	CDD:290200	11/26 (42%)
		C2H2 Zn finger	566..586	CDD:275368	9/21 (43%)
		zf-H2C2_2	578..603	CDD:290200	11/24 (46%)
		C2H2 Zn finger	594..614	CDD:275368	7/19 (37%)
		zf-H2C2_2	606..631	CDD:290200	12/26 (46%)
		ARS2	<620..772	CDD:282772	32/140 (23%)
		C2H2 Zn finger	622..641	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000