DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTF-1 and GLIS1

DIOPT Version :9

Sequence 1:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_001377765.1	Gene:	GLIS1 / 148979	HGNCID:	29525	Length:	803	Species:	Homo sapiens

Alignment Length:	845	Identity:	191/845 - (22%)
Similarity:	268/845 - (31%)	Gaps:	311/845 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RNSLSGSPPVTSNCSSSGSLD-FDRPLA------QLLEPKLEAD-------GLGIIHGDNYSIYG 93
            |.::||     ..|...|..| ..||.|      .||.|:...|       ..|.::|.    ||
Human    37 RVTVSG-----GGCGDRGPRDLLARPPAPPPRAHDLLRPRSPRDYGPSKAAAAGKVNGS----YG 92

  Fly    94 SQTAESTSGEQQVLNLGLTLDTGDAQATYGDLFGAQDQLTASQ--THGHSQVVVSAAADNA--FS 154
            .:|..|   |:.:|:|.|.  .|........||     |.|..  ...|.|     |.:..  |.
Human    93 HRTPGS---EKSLLDLDLA--EGPGPTCCQGLF-----LPAGSPPPRAHPQ-----ACERLLHFP 142

  Fly   155 LADQLTPLPITV-----IPITYHHTTENLS------------SSHSEVPLIASLSDITAQVFNLD 202
            ..|: :|.|...     :|.|.|...|:|.            |:|...||...|..      :||
Human   143 HPDR-SPRPQATYVNGSLPTTQHIKQESLPDYQAMAEARTSLSAHCRGPLATGLHP------DLD 200

  Fly   203 ----------DICFTLEYQFENQRLVQVQ----------------PPT------------VVSL- 228
                      ..|:.|..:..:...:|.:                |||            |.|:
Human   201 LPGRSLATPAPSCYLLGSEPSSGLGLQPETHLPEGSLKRCCVLGLPPTSPASSSPCASSDVTSII 265

  Fly   229 -----SMVSSPNEAANPPINCDNDQGTGNSISRDSTSNSPAYFTIETSYVDEYDPNEPDEDE--- 285
                 |:|:..|...:||:.  .|.|..:..:|..                   |...|..|
Human   266 RSSQTSLVTCVNGLRSPPLT--GDLGGPSKRARPG-------------------PASTDSHEGSL 309

  Fly   286 QLAHCIQPGVLHQDVDEEEVERQDENDQLMALAYESSD-----------------EALSRYRCNY 333
            ||..|.:...|.|:..:|..|....:.|.:...|..|.                 ....|..|.:
Human   310 QLEACRKASFLKQEPADEFSELFGPHQQGLPPPYPLSQLPPGPSLGGLGLGLAGRVVAGRQACRW 374

  Fly   334 ENCYRSYSTIGNL-----RTHLKTHTGDYSFKCPEDGC---HKAFLTSYSLKIHVRVHTKVKPYE 390
            .:|..:|.....|     ::|:....|: .|.|...||   :|.|...|.|.||:|||:..||.:
Human   375 VDCCAAYEQQEELVRHIEKSHIDQRKGE-DFTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNK 438

  Fly   391 C--------EVSGCDKAFNTRYRLHAHLRLHNGETFNCELCQKCFTTLSDLKKHMRTHTQERPYK 447
            |        |..||.|||:         ||.|                  ||.|:|:||.|:||.
Human   439 CMPFPQFFHEFEGCSKAFS---------RLEN------------------LKIHLRSHTGEKPYL 476

  Fly   448 CPEDDCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFSTSHSLKSHKKTHQRQLQNKGRKKR 512
            |....|.|||:.|.....|:|||...|||.||...|.|.::...||:.|.|.|..:.|...:|..
Human   477 CQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPSSLRKHVKAHSAKEQQVRKKLH 541

  Fly   513 P------------LKTQQTKCSDQ----EQKDPQQEEQEEEEFIKEDQPEMTLLNPGSHCSETTS 561
            .            |..||...|.|    :.|......||              |.||.:....|.
Human   542 AGPDTEADVLTECLVLQQLHTSTQLAASDGKGGCGLGQE--------------LLPGVYPGSITP 592

  Fly   562 TD---SGVVL-------------QTLTPQDHLSN-------------------VFILQGNEPLIL 591
            .:   ||::.             .|.:...|||.                   |..|:|..|..|
Human   593 HNGLASGLLPPAHDVPSRHHPLDATTSSHHHLSPLPMAESTRDGLGPGLLSPIVSPLKGLGPPPL 657

  Fly   592 PETSQAYQLSYAAEEEIPSPWIDAGVLVSKPIIP--MAPLTDACVALPTEMP-------SFVNLK 647
            |.:||::.   ...:..|:       |.|||..|  .:|       .|..:|       ||.:::
Human   658 PPSSQSHS---PGGQPFPT-------LPSKPSYPPFQSP-------PPPPLPSPQGYQGSFHSIQ 705

  Fly   648 PTFGNAVSGNMGDPQP-------ETMDVDP-------TVETSLPT-----------PTLELNQPN 687
            ..|.......|.:|..       ||...:|       ::.|.||.           ||....||:
Human   706 SCFPYGDCYRMAEPAAGGDGLVGETHGFNPLRPNGYHSLSTPLPATGYEALAEASCPTALPQQPS 770

Fly 688 687
Human 771 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	49/157 (31%)
		C2H2 Zn finger	331..353	CDD:275368	5/26 (19%)
		zf-H2C2_2	345..372	CDD:290200	9/34 (26%)
		C2H2 Zn finger	361..383	CDD:275368	10/24 (42%)
		zf-H2C2_2	375..402	CDD:290200	15/34 (44%)
		C2H2 Zn finger	391..413	CDD:275368	8/29 (28%)
		zf-C2H2	418..440	CDD:278523	4/21 (19%)
		C2H2 Zn finger	420..440	CDD:275368	4/19 (21%)
		zf-H2C2_2	432..458	CDD:290200	13/25 (52%)
		COG5048	442..>519	CDD:227381	29/88 (33%)
		C2H2 Zn finger	448..470	CDD:275368	8/21 (38%)
		zf-H2C2_2	462..489	CDD:290200	11/26 (42%)
		C2H2 Zn finger	478..500	CDD:275368	8/21 (38%)
		DUF3682	862..>931	CDD:289231
GLIS1	NP_001377765.1	C2H2 Zn finger	376..395	CDD:275368	3/18 (17%)
		C2H2 Zn finger	406..431	CDD:275368	10/24 (42%)
		COG5048	447..>522	CDD:227381	35/101 (35%)
		C2H2 Zn finger	450..469	CDD:275368	12/45 (27%)
		C2H2 Zn finger	477..499	CDD:275368	8/21 (38%)
		C2H2 Zn finger	507..529	CDD:275368	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4667
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960