DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTF-1 and mtf1

DIOPT Version :9

Sequence 1:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	XP_002939525.1	Gene:	mtf1 / 100495484	XenbaseID:	XB-GENE-979128	Length:	727	Species:	Xenopus tropicalis

Alignment Length:	753	Identity:	228/753 - (30%)
Similarity:	323/753 - (42%)	Gaps:	189/753 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 VQPPTVVSLSMVSSPNEAA--NPPINCDNDQGTGNSISRDSTSNSPAYFTIETSYVDEYDPNEPD 282
            |...|.|.:.....|:||.  :...:.|:|...|.::.....:|......:            |:
Frog    39 VYDTTTVLIEQDRPPSEAEEDDEEDDEDDDGNVGTNLPFLDAANEEGLLLL------------PE 91

  Fly   283 EDEQ----LAHCIQPGVLHQDVD--EEEVERQDEND--QLMALAYESSDEALSRYRCNYENCYRS 339
            :|..    :.|.|.|..:|..::  ...:.|..|..  .|.:...|:..:.:.||:|.:|.|.|:
Frog    92 QDAMSQGYVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSECPETKQKEVKRYQCTFEGCPRT 156

  Fly   340 YSTIGNLRTHLKTHTGDYSFKCPEDGCHKAFLTSYSLKIHVRVHTKVKPYECEVSGCDKAFNTRY 404
            |||.||||||.|||.|:|:|.|.:.||.||||||||||||||||||.||:||:|.||:|||||.|
Frog   157 YSTAGNLRTHQKTHRGEYTFVCNQSGCGKAFLTSYSLKIHVRVHTKEKPFECDVQGCEKAFNTLY 221

  Fly   405 RLHAHLRLHNGETFNC--ELCQKCFTTLSDLKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTHR 467
            ||.||.|||.||||||  |.|.|.|||.|||:||:||||:|:|::|..|.|||||.||||||||.
Frog   222 RLRAHQRLHTGETFNCVTEGCSKFFTTHSDLRKHIRTHTREKPFRCDHDGCGKAFAASHHLKTHA 286

  Fly   468 RTHTGEKPYPCQEDSCQKSFSTSHSLKSHKKTH-----QRQLQNKGRKKRPLKTQQTKC------ 521
            |.||||||:.|..|.|:|:|||.:|||||.|.|     :..|.|           .|.|
Frog   287 RKHTGEKPFLCTSDGCEKTFSTQYSLKSHMKGHDITGLEESLPN-----------HTSCEDTNHW 340

  Fly   522 ----------SDQEQKD--------------PQ-------QEEQEEEEFIKEDQPEMTLLNPGSH 555
                      ||.|.::              ||       |..:..::.....|....||...:.
Frog   341 FCLSDVRSLSSDSELRENVDGSPGQSLGQMLPQNLFESMFQSPENTQDTDSTQQKVDALLKTWAT 405

  Fly   556 CS------ETTSTD-SGVVLQTLTPQDHL-----------SNVFILQ------GNEPLILPETSQ 596
            .|      ||:||| :.:.:..:||..::           ||...||      |.:| ..|.|.:
Frog   406 SSETPAAAETSSTDPTSLSIPLVTPPVNVEPPMEKTCAPTSNAAHLQPTTTECGTKP-TPPVTLE 469

  Fly   597 AYQ----------LSYAAEE------EIPSPWIDAGVLVSKPIIPMAPLTDACVALPTEMPSFVN 645
            |.|          ..|...:      :...|.::...:|:...:|:...::      |.||:.|.
Frog   470 ARQSLDLHSANGVTPYTTSQDCLLTPQATQPLVEGLAVVAGHSLPVVSTSE------TSMPTLVQ 528

  Fly   646 LKPTFGNAVSGNMGDPQPETMDVDPTVETSLPTPTLELNQPNIEELLKQDSFENEEDMETESLLN 710
            ......|||..|           .|.: |..|||...|.||::  ::.:.:|:
Frog   529 SAMPSANAVLTN-----------SPAI-TITPTPNAALLQPSL--VMAEQNFQ------------ 567

  Fly   711 DILMTIDNNSALLQATLQQASQV-----------PSDASGLVELDIRDNKPTLKQITADAGICNC 764
                .|.|.:...|...|||::|           |......|: .|..:.|.|  |......|.|
Frog   568 ----WILNGATQSQEQPQQAAKVEKVYFTTTVPLPGSTGNPVQ-QIGLSLPVL--IIKQEESCQC 625

  Fly   765 TNCKC-DQTKSCHGGDCGAAAAQQTTR--------------TGAPTTTTTTTTMNSSGGKRICGS 814
             .|.| |..|.......|.:.|.:...              :.:|...::...:|:||.:....|
Frog   626 -QCACRDSVKEKANKRKGCSPAPEPASDPKPADPPPENLHLSTSPCEGSSGHLLNTSGSQPWTPS 689

  Fly   815 VVPTKK-VSKRETEMNQNIEDVALLLQ----NLASMSS 847
            .:.... :|.:..|...::..:..|||    :|.|.||
Frog   690 SLDISDFLSIQSPENPSSLAPMEALLQGDDISLGSFSS 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	100/143 (70%)
		C2H2 Zn finger	331..353	CDD:275368	14/21 (67%)
		zf-H2C2_2	345..372	CDD:290200	17/26 (65%)
		C2H2 Zn finger	361..383	CDD:275368	17/21 (81%)
		zf-H2C2_2	375..402	CDD:290200	21/26 (81%)
		C2H2 Zn finger	391..413	CDD:275368	15/21 (71%)
		zf-C2H2	418..440	CDD:278523	15/23 (65%)
		C2H2 Zn finger	420..440	CDD:275368	13/21 (62%)
		zf-H2C2_2	432..458	CDD:290200	16/25 (64%)
		COG5048	442..>519	CDD:227381	40/81 (49%)
		C2H2 Zn finger	448..470	CDD:275368	16/21 (76%)
		zf-H2C2_2	462..489	CDD:290200	17/26 (65%)
		C2H2 Zn finger	478..500	CDD:275368	13/21 (62%)
		DUF3682	862..>931	CDD:289231
mtf1	XP_002939525.1	COG5048	<89..297	CDD:227381	117/219 (53%)
		C2H2 Zn finger	151..170	CDD:275368	13/18 (72%)
		C2H2 Zn finger	178..200	CDD:275368	17/21 (81%)
		C2H2 Zn finger	208..230	CDD:275368	15/21 (71%)
		COG5048	239..>360	CDD:227381	60/131 (46%)
		C2H2 Zn finger	240..259	CDD:275368	12/18 (67%)
		C2H2 Zn finger	267..289	CDD:275368	16/21 (76%)
		C2H2 Zn finger	297..319	CDD:275368	13/21 (62%)
		PHA03247	<404..659	CDD:223021	60/295 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11961
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008189
OrthoInspector	1	1.000	-	-		oto102254
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5629
SonicParanoid	1	1.000	-	-		X6153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030