DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MTF-1 and zgc:171422

DIOPT Version :9

Sequence 1:	NP_001097560.1	Gene:	MTF-1 / 39089	FlyBaseID:	FBgn0040305	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_001107944.2	Gene:	zgc:171422 / 100001353	ZFINID:	ZDB-GENE-080204-95	Length:	717	Species:	Danio rerio

Alignment Length:	541	Identity:	129/541 - (23%)
Similarity:	190/541 - (35%)	Gaps:	143/541 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NSLSDSRDYDTNSSRNSLSGSPPVTSNCSSSGSLDFDRPLAQLLEPKLEADGLGIIHGDNYSIYG 93
            |.|..:.|.:|      |:|.|.|.:..|||.|....|          ::||....:.|
Zfish   249 NLLKQTVDKET------LAGDPDVRNEGSSSNSESSFR----------DSDGEKETNAD------ 291

  Fly    94 SQTAESTSGEQQVLNLGLTLDTGDAQATYGDL-FGA------QDQLTASQTHGHSQVVVSAAADN 151
             :..|..|.|..:|:     .|.||..  ||| |.|      .|..|.|.:.|...      |..
Zfish   292 -ELQECNSKEPDLLS-----STNDAHT--GDLIFPAAAPPQRPDSFTNSPSKGFHY------AGR 342

  Fly   152 AFSLADQLTPLPITVIPITYHHTTENLSSSHSEVPLIASLSDITAQVFNLDDICFT--------- 207
            ......|.|...|....:..|..|.....:|..:.......|.|....:....|.|
Zfish   343 TVHRCQQCTKYFIYRSDLAKHQETHTKPGAHECLQCGQDFEDSTQLAAHRISSCNTRVFKCVKCR 407

  Fly   208 -----LEYQFENQRLVQVQPP--------TVVSLSMVSSPNEAANPPINCDNDQGTGNSISRDST 259
                 |...:::.|:.:.:..        |..|||.:.|.......|
Zfish   408 AHFRSLRTLYKHNRMHKEKTTHKCPECGRTFTSLSQLVSHRRGHRTP------------------ 454

  Fly   260 SNSPAYFTIETSYVDEYDPNEPDEDEQLAHCIQPGVLHQDVDEEEVERQDEND------QLMALA 318
                   ||:.:|..:       :..:.....:..::||.:.:.:..|..::|      :...|.
Zfish   455 -------TIKRNYTCK-------QCNETFGSYRASLIHQKIHKADAARPSKSDRQPGKCRFCDLT 505

  Fly   319 YESSDEALSRYRCNYE-------NCYRSYSTIGNLRTHLKTHTGDYSFKCPEDG----------- 365
            :....|..|..:.:.|       .|.:.:|...:|..||..|||:....|.:.|
Zfish   506 FNIDSELRSHLKTHAEFRPYICDQCGKCFSANSSLLAHLSNHTGEKPLLCSQCGKRFYSKIQLKS 570

  Fly   366 ---------------CHKAFLTSYSLKIHVRVHTKVKPYECEVSGCDKAFNTRYRLHAHLRLHNG 415
                           |.|.|..|.:||||:|:||..|||.|.  .|.|.|.:...|..|||.|.|
Zfish   571 HMRCHSGERPHICPYCEKQFSLSGNLKIHIRIHTGEKPYVCH--QCGKGFVSAGCLQVHLRSHTG 633

  Fly   416 E-TFNCELCQKCFTTLSDLKKHMRTHTQERPYKCPEDDCGKAFTASHHLKTHRRTHTGEKPYPCQ 479
            | .:.|::|.|.|...|.|..||..||.|||:.|.:  |||.|...:.|..|..||.|::|:||
Zfish   634 EKPYQCKICGKKFVVSSHLTAHMCFHTGERPHCCMQ--CGKRFIRRYDLSKHMYTHIGKRPFPC- 695

  Fly   480 EDSCQKSFSTSHSLKSHKKTH 500
             ..|.|:::....|..|.|:|
Zfish   696 -PMCPKAYTCRTHLNRHMKSH 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MTF-1	NP_001097560.1	zf-C2H2_aberr	329..471	CDD:293622	57/175 (33%)
		C2H2 Zn finger	331..353	CDD:275368	6/28 (21%)
		zf-H2C2_2	345..372	CDD:290200	11/52 (21%)
		C2H2 Zn finger	361..383	CDD:275368	11/47 (23%)
		zf-H2C2_2	375..402	CDD:290200	14/26 (54%)
		C2H2 Zn finger	391..413	CDD:275368	8/21 (38%)
		zf-C2H2	418..440	CDD:278523	8/21 (38%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..458	CDD:290200	12/25 (48%)
		COG5048	442..>519	CDD:227381	22/59 (37%)
		C2H2 Zn finger	448..470	CDD:275368	7/21 (33%)
		zf-H2C2_2	462..489	CDD:290200	10/26 (38%)
		C2H2 Zn finger	478..500	CDD:275368	6/21 (29%)
		DUF3682	862..>931	CDD:289231
zgc:171422	NP_001107944.2	TIN2_N	18..189	CDD:240667
		C2H2 Zn finger	347..367	CDD:275368	4/19 (21%)
		zf-C2H2_8	350..419	CDD:292531	10/68 (15%)
		C2H2 Zn finger	375..392	CDD:275368	2/16 (13%)
		C2H2 Zn finger	403..423	CDD:275368	2/19 (11%)
		zf-C2H2_8	406..478	CDD:292531	11/103 (11%)
		C2H2 Zn finger	431..451	CDD:275368	5/19 (26%)
		C2H2 Zn finger	462..482	CDD:275368	2/26 (8%)
		C2H2 Zn finger	499..519	CDD:275368	3/19 (16%)
		COG5048	<524..683	CDD:227381	54/162 (33%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		C2H2 Zn finger	555..575	CDD:275368	2/19 (11%)
		zf-H2C2_2	568..591	CDD:290200	2/22 (9%)
		C2H2 Zn finger	583..603	CDD:275368	9/19 (47%)
		zf-H2C2_2	595..620	CDD:290200	14/26 (54%)
		C2H2 Zn finger	611..631	CDD:275368	8/21 (38%)
		zf-H2C2_2	624..647	CDD:290200	10/22 (45%)
		zf-C2H2	637..659	CDD:278523	8/21 (38%)
		C2H2 Zn finger	639..659	CDD:275368	8/19 (42%)
		C2H2 Zn finger	667..687	CDD:275368	7/21 (33%)
		zf-H2C2_2	679..704	CDD:290200	10/26 (38%)
		C2H2 Zn finger	695..715	CDD:275368	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100