DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpsf5 and Nudt21

DIOPT Version :9

Sequence 1:	NP_001036597.1	Gene:	Cpsf5 / 39083	FlyBaseID:	FBgn0035987	Length:	237	Species:	Drosophila melanogaster
Sequence 2:	NP_080899.1	Gene:	Nudt21 / 68219	MGIID:	1915469	Length:	227	Species:	Mus musculus

Alignment Length:	231	Identity:	179/231 - (77%)
Similarity:	195/231 - (84%)	Gaps:	13/231 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NKSGSGWPRRGSQGQADAASSNNNGTQKYTNQA--LTINRTINLYPLTNYTFGTKEPLFEKDPSV 70
            |:|.:||||           ..|....||..|.  ||:.|||||||||||||||||||:|||.||
Mouse     7 NRSQTGWPR-----------GVNQFGNKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSSV 60

  Fly    71 PSRFQRMREEFDRIGMRRSVEGVLLVHEHGLPHVLLLQLGTTFFKLPGGELNAGEDEVEGLKRLL 135
            .:||||||||||:|||||:|||||:||||.||||||||||||||||||||||.|||||||||||:
Mouse    61 AARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEGLKRLM 125

  Fly   136 SETLGRQDGVKQEWIVEDTIGNWWRPNFEPPQYPYIPPHITKPKEHKRLFLVQLHEKALFAVPKN 200
            :|.|||||||.|:|:::|.||||||||||||||||||.|||||||||:||||||.||||||||||
Mouse   126 TEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPKN 190

  Fly   201 YKLVAAPLFELYDNSQGYGPIISSLPQALCRFNFIY 236
            ||||||||||||||:.|||||||||||.|.||||||
Mouse   191 YKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIY 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf5	NP_001036597.1	NUDIX_2	45..232	CDD:404710	161/186 (87%)
Nudt21	NP_080899.1	Necessary for RNA-binding. /evidence=ECO:0000250\|UniProtKB:O43809	2..147		105/150 (70%)
		NUDIX_2	35..222	CDD:404710	161/186 (87%)
		Necessary for interactions with PAPOLA and PABPN1. /evidence=ECO:0000250\|UniProtKB:O43809	81..160		66/78 (85%)
		Interaction with RNA. /evidence=ECO:0000250\|UniProtKB:O43809	102..104		1/1 (100%)
		Nudix box	109..130		16/20 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842622
Domainoid	1	1.000	346	1.000	Domainoid score	I1049
eggNOG	1	0.900	-	-		E1_KOG1689
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5090
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2134
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54579
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006316
OrthoInspector	1	1.000	-	-		oto93558
orthoMCL	1	0.900	-	-		OOG6_102904
Panther	1	1.100	-	-	LDO	PTHR13047
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4135
SonicParanoid	1	1.000	-	-		X4023
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790