DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpsf5 and NUDT21

DIOPT Version :9

Sequence 1:	NP_001036597.1	Gene:	Cpsf5 / 39083	FlyBaseID:	FBgn0035987	Length:	237	Species:	Drosophila melanogaster
Sequence 2:	NP_008937.1	Gene:	NUDT21 / 11051	HGNCID:	13870	Length:	227	Species:	Homo sapiens

Alignment Length:	232	Identity:	180/232 - (77%)
Similarity:	197/232 - (84%)	Gaps:	15/232 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NKSGSGWPRRGSQ-GQADAASSNNNGTQKYTNQA--LTINRTINLYPLTNYTFGTKEPLFEKDPS 69
            |:|.:||||..:| |            .||..|.  ||:.|||||||||||||||||||:|||.|
Human     7 NRSQTGWPRGVTQFG------------NKYIQQTKPLTLERTINLYPLTNYTFGTKEPLYEKDSS 59

  Fly    70 VPSRFQRMREEFDRIGMRRSVEGVLLVHEHGLPHVLLLQLGTTFFKLPGGELNAGEDEVEGLKRL 134
            |.:||||||||||:|||||:|||||:||||.||||||||||||||||||||||.|||||||||||
Human    60 VAARFQRMREEFDKIGMRRTVEGVLIVHEHRLPHVLLLQLGTTFFKLPGGELNPGEDEVEGLKRL 124

  Fly   135 LSETLGRQDGVKQEWIVEDTIGNWWRPNFEPPQYPYIPPHITKPKEHKRLFLVQLHEKALFAVPK 199
            ::|.|||||||.|:|:::|.||||||||||||||||||.|||||||||:||||||.|||||||||
Human   125 MTEILGRQDGVLQDWVIDDCIGNWWRPNFEPPQYPYIPAHITKPKEHKKLFLVQLQEKALFAVPK 189

  Fly   200 NYKLVAAPLFELYDNSQGYGPIISSLPQALCRFNFIY 236
            |||||||||||||||:.|||||||||||.|.||||||
Human   190 NYKLVAAPLFELYDNAPGYGPIISSLPQLLSRFNFIY 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpsf5	NP_001036597.1	NUDIX_2	45..232	CDD:404710	161/186 (87%)
NUDT21	NP_008937.1	Necessary for RNA-binding. /evidence=ECO:0000269\|PubMed:15169763	2..147		106/151 (70%)
		NUDIX_2	35..222	CDD:404710	161/186 (87%)
		Necessary for interactions with PAPOLA and PABPN1. /evidence=ECO:0000269\|PubMed:15169763	81..160		66/78 (85%)
		Interaction with RNA. /evidence=ECO:0000269\|PubMed:20479262, ECO:0000269\|PubMed:21295486, ECO:0000312\|PDB:3MDG, ECO:0000312\|PDB:3MDI, ECO:0000312\|PDB:3Q2T	102..104		1/1 (100%)
		Nudix box	109..130		16/20 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152562
Domainoid	1	1.000	346	1.000	Domainoid score	I1047
eggNOG	1	0.900	-	-		E1_KOG1689
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5090
Inparanoid	1	1.050	368	1.000	Inparanoid score	I2156
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54579
OrthoDB	1	1.010	-	-		D1194206at2759
OrthoFinder	1	1.000	-	-		FOG0006316
OrthoInspector	1	1.000	-	-		oto89982
orthoMCL	1	0.900	-	-		OOG6_102904
Panther	1	1.100	-	-	LDO	PTHR13047
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4023
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770