Protein Alignment LAMA2 and CG6059

DIOPT Version :10

• Sequence 1: NP_000417.3
• Gene: LAMA2 / 3908
• HGNCID: 6482
• Length: 3122
• Species: Homo sapiens
• Sequence 2: NP_651541.2
• Gene: CG6059 / 43270
• FlyBaseID: FBgn0039491
• Length: 884
• Species: Drosophila melanogaster
• Alignment Length: 665
• Identity: 139/665 - (20%)
• Similarity: 250/665 - (37%)
• Gaps: 166/665 - (24%)

Human  1564 HAREGWECVFCGDECT-------GLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQELKH 1621
            |.||..|..:..::.|       .|.|..|.|.:|..|:...|..:|...|.|.....:.:|...
  Fly   123 HLRESLEDAWRNEDATKNREETMQLQLMSLVRSDQSNMTKGTTDHVPISNKDLQLHRLVLRERDR 187

Human  1622 LLSPQRAPERLIQLAEGNLNTLVTEMNELLTRA-----TKVTADGEQTGQD----AERTNTRAKS 1677
            |.:..:..::.:|     .|.|.:|..|::...     :|:.|..::...|    ..|.|.....
  Fly   188 LAAELKDHQKRLQ-----TNRLYSESVEVMIEVYKEIISKLNARAKKAELDNFRLEHRCNVEQDK 247

Human  1678 LGEFIKELARDAEAVNEKAIKLNET------LGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQ 1736
            ..:.:..|.::..||.::..:|...      |...:||.::..:.|.:|...:.|.||
  Fly   248 YEDRLLHLNKELVAVVQQNEELQAAEKDFMELAATNEALKQRSDRLSRENHTLTKSLR------- 305

Human  1737 KEIAEDELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLRE---ATDKIR 1798
              |.|||....:..||..:.|....|.:..::|...|....|.|.|.||:..|.|.   ...|..
  Fly   306 --IMEDEKNKLQTSLKVSEGLNDAQRRDKLDLELARRSAERDAKKKADDSMILERRFHLLAKKNT 368

Human  1799 EANRLFAVNQKNMTALEKK--------KEAVESGKRQIENTLKEGNDILDEANRLAD-------E 1848
            |.|....|||..:...|||        .||:    ||.|...:..:.:..|.:||.|       |
  Fly   369 ELNDQVLVNQNELKVQEKKMLMATAKLNEAI----RQKEEIARSRDKLRAEISRLNDIVAGVRHE 429

Human  1849 INSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLA-EKVSQAESHAAQLNDSSAVLDGILD 1912
            |.||...::|:.|.|...:::|::|      :::.:|:| ||..|    :.:|||:...:|||
  Fly   430 IASIRHQMQDLLTDLLRANKQLDEK------DLQVQKIAREKREQ----SLELNDAYKKIDGI-- 482

Human  1913 EAKNISFNATAAFKA----------------YSNIKDYID--EAEKVAKEAKDLAHEATKLATGP 1959
                   ..|.|.|:                ::|:|..::  ::|||
  Fly   483 -------EETLALKSERLEVLQVELQQKQQEFANVKKQMEVIQSEKV------------------ 522

Human  1960 RGLLKEDAKGCLQKSFRILNEAKKLANDVKE-------NEDHLNGLKTRIENADARNGDLLRTLN 2017
              :|.:....|.:....:.|...||.:.:.:       ||..::.||.:||       .|.||:.
  Fly   523 --MLMKTMDMCSRDRSTLQNTMTKLTHQINQMTSSLAINEKEISSLKNQIE-------QLNRTVK 578

Human  2018 DTLGKL---SAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKT 2079
            ....::   |.:...|...|:.:|.:..||..|              :|..:|.:..:|
  Fly   579 QKQNEIHAKSRLLASTKTDLREMKIRLEQAAHT--------------IDTDEKRFKNMA------ 623

Human  2080 NAVVKDPSKNKIIADADATVKNLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSI 2144
             ..:.:.:|.|.:.......:|         |:::.::|..|.::|.|.......||..:....:
  Fly   624 -CALDEVTKEKSLVGLQMVRRN---------DEVRLLREKLDMMQKAIDRGTMQYNQRVEDIRLL 678

Human  2145 K---VSVSSGGDCIR 2156
            |   |::.:..:|::
  Fly   679 KLEVVNLRTSHECMQ 693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LAMA2	NP_000417.3	LamNT	37..285	CDD:214532
		EGF_Lam	287..334	CDD:238012
		Laminin_EGF	414..471	CDD:395007
		Laminin_EGF	469..515	CDD:395007
		LamB	578..710	CDD:214597
		EGF_Lam	756..805	CDD:238012
		Laminin_EGF	807..862	CDD:395007
		EGF_Lam	864..916	CDD:238012
		EGF_Lam	917..965	CDD:238012
		EGF_Lam	967..1011	CDD:214543
		EGF_Lam	1014..1057	CDD:214543
		Laminin_EGF	1060..1108	CDD:395007
		Laminin_EGF	1106..1163	CDD:395007
		LamB	1229..1364	CDD:214597
		Laminin_EGF	1420..1466	CDD:395007
		Laminin_EGF	1469..1524	CDD:395007
		EGF_Lam	1527..1574	CDD:238012	4/9 (44%)
		Domain II and I	1574..2144		132/638 (21%)
		Laminin_I	1593..1852	CDD:310534	66/291 (23%)
		SMC_prok_B	1718..>2077	CDD:274008	91/405 (22%)
		Laminin_II	2037..2173	CDD:368703	20/123 (16%)
		Laminin_G_1	2174..2314	CDD:395008
		Laminin_G_1	2368..2507	CDD:395008
		Laminin_G_1	2554..2695	CDD:395008
		Laminin_G_1	2793..2921	CDD:395008
		LamG	2941..3093	CDD:238058
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3043..3063
CG6059	NP_651541.2	Smc	<251..>524	CDD:440809	75/324 (23%)
		SMC_prok_B	<425..715	CDD:274008	65/345 (19%)