Protein Alignment LAMA2 and CG11248

DIOPT Version :10

• Sequence 1: NP_000417.3
• Gene: LAMA2 / 3908
• HGNCID: 6482
• Length: 3122
• Species: Homo sapiens
• Sequence 2: NP_649348.1
• Gene: CG11248 / 40411
• FlyBaseID: FBgn0037117
• Length: 830
• Species: Drosophila melanogaster
• Alignment Length: 674
• Identity: 145/674 - (21%)
• Similarity: 261/674 - (38%)
• Gaps: 168/674 - (24%)

Human  1586 LARLEQMVMSINL-----TGPLPAPYKMLYGLENMTQELKHLLSPQRAPERLIQLAEGNLNTLVT 1645
            |::|:|.|:.:.|     ||..    |.|..|::   :::|.|..:....|.:......|..::.
  Fly   182 LSQLQQTVVGMELESKHVTGKC----KQLLDLKS---QMEHQLELRSTTLRSVTAERDQLRQVIA 239

Human  1646 EMNELLTRATKVTADGEQTGQDA-------------------------ERTNTRA-------KSL 1678
            |:||.|.....:.|..||...|.                         |..|.:.       .||
  Fly   240 ELNETLQTQEHLLALKEQEFLDLKQYYQQKLKRESSMEIMHSYSMKFHEEINRKTSEIASLKNSL 304

Human  1679 GEFIKEL----------------------ARDAEAVNE------KAIKLN--ETLGTRDEAFERN 1713
            .|...||                      |..|:.:.|      .|:||.  |.|.....:.:.:
  Fly   305 NELQAELMLMSHMKEQCEEQQRQLEQLEFALQAQLLEETQLRQSNALKLEQVENLTISLASLQLD 369

Human  1714 LEGLQKEIDQMIKELRRKNLETQKEIAEDELVAAEALLKKVKKLFGESRGENEEM-------EKD 1771
            .|||::.:.:..|.|  |||:.:.:|.:.:.....:|.:|.|:.....:.|..:|       |.:
  Fly   370 KEGLKENLGEAQKTL--KNLQQKVDILQKQYAEMCSLCQKTKQQLELEKIEIAKMKQNGSLKESE 432

Human  1772 LREKLADYKNKVDDAWDLLREATDKI------REANRL-FAVNQKNMT------------ALEKK 1817
            |.|||.||..:.|:....|.||..:|      .|..:: ...||...|            .||::
  Fly   433 LMEKLKDYAAQCDELRKALAEAESRIDVQIKKTEGWQVQLKHNQATQTDLEDPILVQRIETLEQQ 497

Human  1818 KEAVESGK-----------RQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMS---E 1868
            ...|.|.|           :|.|..:|..|::..:..:|.|.:.:.....::::::|...:   |
  Fly   498 LADVRSQKLHTVSLLQILLQQQEAKIKSTNEMEADWQQLLDALQATQSLEQEMRSELQHKTVELE 562

Human  1869 ELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFNATAAF---KAYSN 1930
            .||:.....:.|:  :|| :|:|||:....:|  ...:|.....|  |:..|:.|:.   :....
  Fly   563 HLNELFAGQNDEL--QKL-QKLSQAQDEENRL--ELQLLKKTFQE--NLKINSAASINMQRLQGQ 620

Human  1931 IKDYIDEAEKVAKE-------AKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDV 1988
            :|..:||.|::|:|       .:.|.| ..::.|| |.|....:...|.|..|     |:|.|..
  Fly   621 VKSLLDEKEEIAREERKAVECLRSLGH-VLEMETG-RRLPHIKSWPQLAKILR-----KELRNGR 678

Human  1989 KENE--DHLNGLKTRIENADARNGDLL---RTLNDTL------------GKLSA--IPNDTAAKL 2034
            ..|.  :.|.|||.::.....|:...|   :.|..||            ||.:|  .|.:.|.::
  Fly   679 VNNRKAEELPGLKMKLAEISGRHQQALSKIKCLEHTLVMERARFEASDSGKSTASNTPQEPAHEV 743

Human  2035 QAVKDKARQ-----ANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIAD 2094
            ..:.|..::     ||:|.:...:.|.:|.:.....:.|..:|.:.::...:.:|:.|: .|||.
  Fly   744 ANLIDDYKKLVQQTANETCRPRNSFIFDLIERSQRCQPNLCQLGEGISACQSDMKELSR-IIIAG 807

Human  2095 ADATVKNLEQEADRLIDKLKPIKE 2118
            .:   :...:....|:|:|:.:.|
  Fly   808 RE---RRRVEPMPSLMDELRAVAE 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LAMA2	NP_000417.3	LamNT	37..285	CDD:214532
		EGF_Lam	287..334	CDD:238012
		Laminin_EGF	414..471	CDD:395007
		Laminin_EGF	469..515	CDD:395007
		LamB	578..710	CDD:214597
		EGF_Lam	756..805	CDD:238012
		Laminin_EGF	807..862	CDD:395007
		EGF_Lam	864..916	CDD:238012
		EGF_Lam	917..965	CDD:238012
		EGF_Lam	967..1011	CDD:214543
		EGF_Lam	1014..1057	CDD:214543
		Laminin_EGF	1060..1108	CDD:395007
		Laminin_EGF	1106..1163	CDD:395007
		LamB	1229..1364	CDD:214597
		Laminin_EGF	1420..1466	CDD:395007
		Laminin_EGF	1469..1524	CDD:395007
		EGF_Lam	1527..1574	CDD:238012
		Domain II and I	1574..2144		145/674 (22%)
		Laminin_I	1593..1852	CDD:310534	75/362 (21%)
		SMC_prok_B	1718..>2077	CDD:274008	96/432 (22%)
		Laminin_II	2037..2173	CDD:368703	17/87 (20%)
		Laminin_G_1	2174..2314	CDD:395008
		Laminin_G_1	2368..2507	CDD:395008
		Laminin_G_1	2554..2695	CDD:395008
		Laminin_G_1	2793..2921	CDD:395008
		LamG	2941..3093	CDD:238058
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3043..3063
CG11248	NP_649348.1	Smc	<144..702	CDD:440809	119/542 (22%)