DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LAMA2 and LanB2

DIOPT Version :10

Sequence 1:NP_000417.3 Gene:LAMA2 / 3908 HGNCID:6482 Length:3122 Species:Homo sapiens
Sequence 2:NP_524006.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster


Alignment Length:2235 Identity:559/2235 - (25%)
Similarity:833/2235 - (37%) Gaps:738/2235 - (33%)


- Green bases have known domain annotations that are detailed below.


Human     6 GVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRG------------------LFPAVLNLASNALI 52
            |||.....:..||   |||| ....:..|:.||                  ..|..:|.|....|
  Fly    20 GVLFASCSTAILG---AQRP-PINSAGGHELRGTTFMPALECYDPYGRPQKCLPEFINAAYQLQI 80

Human    53 TTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQRHPITNAIDGKN-TWWQSPSIK 116
            .:..||||:....:|     :......:..|..|..|..||:.   :|:..|.:: |||||.::.
  Fly    81 ESTNTCGEQNDNHFC-----IQTMNQNHKNCEFCKYNDHNPSF---LTDLHDPQSPTWWQSETMF 137

Human   117 NGIEY-HYVTITLDLQQVFQIAYVIVKAANSPRPGNW-ILERSLDDVEYKPWQYHAVTDTECLTL 179
            .||:: :||.:||.|.:.:.|.||.: ...||||.:: |.:|:.:...:.|:|:::.|   |...
  Fly   138 EGIQHPNYVNLTLHLGKSYDITYVRI-LFRSPRPESFTIYKRTSESGPWIPYQFYSAT---CRDT 198

Human   180 YNIYPRTGPPSYA-----KDDEVICTSFYSKIHPLENGEIHISLINGRPSA--DDPSPELLEFTS 237
            |::     |.|.|     .:...:|||.||.|.||.:|||..|.:.||||.  .:.|.||.|:.:
  Fly   199 YSL-----PDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGINFERSGELQEWVT 258

Human   238 ARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPAT 302
            |..||:...|:.|...:|..         |..|.:.|:|::.||:||..|.|.|||..|......
  Fly   259 ATDIRITLDRLNTFGDELFG---------DSQVLKSYFYAISDIAVGARCKCNGHASKCVPSTGM 314

Human   303 NKSR---CECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNL 364
            :..|   |||.|||.|..||:|.|.::...|:..|.....||:||||:|.|::|::|.|:..|. 
  Fly   315 HGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDANLFNRT- 378

Human   365 SLNIRGKYIG-GGVCINCTQNTAGINCETCTDGFF-RPKGVSPNYPRPCQPCHCDPIGSLNEVCV 427
                     | ||.|::|.:|..|.|||.|.:.|: |..|.       |..|.|||:||.:..| 
  Fly   379 ---------GHGGHCLDCRENRDGPNCERCKENFYMRDDGY-------CVNCACDPVGSRSLQC- 426

Human   428 KDEKHARRGLAPGSCHCKTGFGGVSCDRCARGY--TGYPDCKACNCSGLGSKNEDPC----FGPC 486
              ..|       |.|.||.|..|..||||...|  .|...|:.|.|...||....|.    .|.|
  Fly   427 --NSH-------GKCQCKPGVTGDKCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGIC 482

Human   487 ICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVSNRCQ--------SSYWTYGKIQDMSGW 543
            .|||||||..|:.||.|||||.::|..||..|||.|.::.|.        |....:.|.::.  |
  Fly   483 FCKENVEGRRCNECKPGFFNLDKNNRFGCTPCFCYGHTSECMTAPGYSIVSVTSNFNKFKER--W 545

Human   544 YLTDLPGRIRVAPQQDDLD-SPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTIS 607
            ...||        .|.::| ...|.|.|.....|...|.|: .||..:||::..:....|.|.  
  Fly   546 TAADL--------NQREVDIKYNQYSRSIGTTAQGNEHVYF-QAPDRFLGDQRASYNRDLKFK-- 599

Human   608 YDLEEEEEDTERVLQLM----------IILEGNDLSIST---AQDEVYLHPSEEHTNVLLLKEES 659
                         |||:          :||||....||.   ||....  |.:.      :||.:
  Fly   600 -------------LQLVGQVANTGVSDVILEGAGSRISLPIFAQGNGI--PDQG------VKEYT 643

Human   660 FTIHGTH----FPVR-RKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLES----AVSYPTDG 715
            |.:|..|    .|.: .:.|:::|:||..:.::.|||...:||  |..|.|::    |..:|   
  Fly   644 FRLHEHHDYQWQPSQSARGFLSILSNLTAIKIRATYSVQGEAI--LDDVELQTAHRGAAGHP--- 703

Human   716 SIAAAVEVCQCPPGYTGSSCESCWP--RHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKD 778
              |..:|.|.||.||.|..||||.|  ||....|..|.. |.||.|.|||:.||..||.|: |:.
  Fly   704 --ATWIEQCTCPEGYLGQFCESCAPGYRHSPARGGPFMP-CIPCDCHGHADICDSETGRCI-CQH 764

Human   779 HTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPR 843
            :|.|..||:|..||||....||..||:.|.||      |......::... :||..||.||.|.|
  Fly   765 NTHGDNCDQCAKGFYGNALGGTPNDCKRCPCP------NDGACLQINEDT-VICTECPKGYFGSR 822

Human   844 CERCAEGYFGQPSVPGG---SCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGY 905
            ||:|::|:||.|:...|   :|:.|.||.|:|.:..|:|:..:|.||.|...|.|.:|:.|..|:
  Fly   823 CEQCSDGFFGDPTGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLSGH 887

Human   906 FGD--AVDAKNCQPCRCNAGGSFSEV-----CHSQTGQCECRANVQGQRCDKCKAGTFGLQSARG 963
            |||  |:....|..|.|...|:..:.     |...||||:|:.||.|:.|.:|:.|.|.::|..|
  Fly   888 FGDPLALPHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSGNG 952

Human   964 CVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACECSHLGNNCDPKT 1027
            |..|.|:..||.:..|:. ||||.|:|||.|::||:|.:.::.|.                    
  Fly   953 CENCLCDPVGSYNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGFS-------------------- 997

Human  1028 GRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVGSLDFQCNVNTGQCNCHPKFSGAKCTE 1092
                                      :.|||.|.|...||..|||                    
  Fly   998 --------------------------SEGCKPCECDESGSKGFQC-------------------- 1016

Human  1093 CSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDA 1157
                                                ||.|||.|..||||..||||:..|:... 
  Fly  1017 ------------------------------------DQNGQCPCNDNVEGRRCDRCKENKYDRH- 1044

Human  1158 KNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQHTTTKGIVFQHPEIVAHMD 1222
            :..:.|..||     ....:|..|.|..: ....||:    ||                 :|...
  Fly  1045 RGCIDCPDCY-----NLVQDAADLHRAKL-FNLSQTL----DE-----------------IARTP 1082

Human  1223 LMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEAREETGFSTYNPQVIIRGGTPTHARII 1287
            :..:|            :||. ||.|...|:. .:..:||:.:|           .|..|:|.:|
  Fly  1083 VTNDD------------EFEA-KLKAVQEKVA-VLAQDARDNSG-----------DGGQTYAEVI 1122

Human  1288 VRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQS 1352
                                        ||...|....||..:.                     
  Fly  1123 ----------------------------DDLHKHLDSVREHLVS--------------------- 1138

Human  1353 RISEISMEVAEQGRGTTMTPPADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTC 1417
                                 ||..:                                       
  Fly  1139 ---------------------ADKFQ--------------------------------------- 1143

Human  1418 VPCQCNGHSSLCDPETSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSP 1482
                       .|....|.:..|::|..|          .|.:....:.||              
  Fly  1144 -----------ADANGEIDRARQNYTILD----------QITENAKKELQQ-------------- 1173

Human  1483 SCVAEGLDDYRCTACPRGYE-----GQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPV 1542
              ..:.|:|....|..|..|     ||..|:                                  
  Fly  1174 --ALDLLNDEGAQALARAKEKSVEFGQQSEQ---------------------------------- 1202

Human  1543 TGFCTCRPGATGRKCDGCKHWHAREGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYK 1607
                                                    :.|::|..:.:..            
  Fly  1203 ----------------------------------------ISDISREARALAD------------ 1215

Human  1608 MLYGLENMTQ-ELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQTGQDAERT 1671
               .||:..| :||:....:.|.|:..|||:..::..:....||.:          :.|.:....
  Fly  1216 ---KLESEAQFDLKNAKDAKDAVEKAHQLAKSAIDLQLKIGTELRS----------EVGLELSHV 1267

Human  1672 NTRAKSLGEFI---KELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNL 1733
            .   :|||..:   ||..|.|..|.:.|:.|...:..:          .|.|||  |.:|::   
  Fly  1268 K---QSLGTVVQTSKEALRKANEVYDTALTLLNDVNRQ----------TQPEID--ISQLKK--- 1314

Human  1734 ETQKEIAEDELVAAEALLKKVKKLFGESRGE---NEEMEKDLREKLADYKNKVDDAWDLLREATD 1795
               ..:|.:|  .|:.|||::.:| ..|.||   :.|.|::|.|.|            |.|....
  Fly  1315 ---DAVAANE--RADELLKQITEL-SNSNGELFADFETEQELTEAL------------LKRAEQQ 1361

Human  1796 KIREANRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQ 1860
            ::.:...|    ::...|.:|..:|||.|    :|||||.|:..::          :..:..|:|
  Fly  1362 QLEDIELL----ERAKAAHDKATKAVEQG----DNTLKEANNTYEK----------LAGFQSDVQ 1408

Human  1861 TKLPPMSEELNDKIDDLSQEIKDRKLAEK-VSQAESHAAQLNDSSAVLDGILDEAKNISFNATAA 1924
             :....:|:....:.::.:||::   ||. :||||.          .|||....|.....||..|
  Fly  1409 -RSSESAEKALQTVPNIEKEIQN---AESLISQAEE----------ALDGANKNANEAKKNAQEA 1459

Human  1925 FKAYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVK 1989
            ...|         ||:.:|:|:.:..:|                          ||.|..|.:::
  Fly  1460 QLKY---------AEQASKDAELIRRKA--------------------------NETKVAARNLR 1489

Human  1990 ENEDHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQ 2054
            |..|.||. :.::...|....:...|.:|.|             :...|.|..||....::...|
  Fly  1490 EEADQLNH-RVKLTEMDIFKLEESSTKDDNL-------------VDDAKRKVGQAKADTQEAQKQ 1540

Human  2055 ITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEADRL-----IDKLK 2114
            |.:.:.:|..:|.....|.|    .|....|..:|::     |||   |.|.:|:     |:|.:
  Fly  1541 IEKANADLTAIKDELENLKD----INTGDLDRLENRL-----ATV---EGEINRVNLTGRIEKYR 1593

Human  2115 PIKELEDNL-KKNISEIKELINQAR 2138
            ..:.::.|| .|..:|::||.::.:
  Fly  1594 EQRTIQKNLIDKYDAELRELKDEVQ 1618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LAMA2NP_000417.3 LamNT 37..285 CDD:214532 80/275 (29%)
EGF_Lam 287..334 CDD:238012 19/49 (39%)
Laminin_EGF 414..471 CDD:395007 22/58 (38%)
Laminin_EGF 469..515 CDD:395007 23/49 (47%)
LamB 578..710 CDD:214597 39/153 (25%)
EGF_Lam 756..805 CDD:238012 24/48 (50%)
Laminin_EGF 807..862 CDD:395007 20/57 (35%)
EGF_Lam 864..916 CDD:238012 20/53 (38%)
EGF_Lam 917..965 CDD:238012 18/52 (35%)
EGF_Lam 967..1011 CDD:214543 18/44 (41%)
EGF_Lam 1014..1057 CDD:214543 0/42 (0%)
Laminin_EGF 1060..1108 CDD:395007 7/47 (15%)
Laminin_EGF 1106..1163 CDD:395007 15/56 (27%)
LamB 1229..1364 CDD:214597 18/134 (13%)
Laminin_EGF 1420..1466 CDD:395007 6/45 (13%)
Laminin_EGF 1469..1524 CDD:395007 8/59 (14%)
EGF_Lam 1527..1574 CDD:238012 0/46 (0%)
Domain II and I 1574..2144 124/579 (21%)
Laminin_I 1593..1852 CDD:310534 59/265 (22%)
SMC_prok_B 1718..>2077 CDD:274008 82/362 (23%)
Laminin_II 2037..2173 CDD:368703 27/108 (25%)
Laminin_G_1 2174..2314 CDD:395008
Laminin_G_1 2368..2507 CDD:395008
Laminin_G_1 2554..2695 CDD:395008
Laminin_G_1 2793..2921 CDD:395008
LamG 2941..3093 CDD:238058
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3043..3063
LanB2NP_524006.1 LamNT 61..296 CDD:214532 77/260 (30%)
EGF_Lam 298..347 CDD:238012 19/48 (40%)
Laminin_EGF 359..414 CDD:395007 24/71 (34%)
EGF_Lam 414..458 CDD:214543 20/53 (38%)
Laminin_EGF 461..511 CDD:395007 23/49 (47%)
LamB 572..697 CDD:214597 38/150 (25%)
EGF_Lam 743..791 CDD:238012 24/48 (50%)
EGF_Lam 793..836 CDD:214543 19/49 (39%)
Laminin_EGF 847..897 CDD:395007 20/49 (41%)
Laminin_EGF 902..953 CDD:395007 17/50 (34%)
EGF_Lam 956..1001 CDD:214543 18/90 (20%)
Laminin_EGF 1004..1046 CDD:395007 22/98 (22%)
SMC_prok_B <1054..1621 CDD:274008 170/991 (17%)
Blue background indicates that the domain is not in the aligned region.

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