Protein Alignment LAMA2 and SP2353

DIOPT Version :10

• Sequence 1: NP_000417.3
• Gene: LAMA2 / 3908
• HGNCID: 6482
• Length: 3122
• Species: Homo sapiens
• Sequence 2: NP_611082.2
• Gene: SP2353 / 36771
• FlyBaseID: FBgn0034070
• Length: 1361
• Species: Drosophila melanogaster
• Alignment Length: 1414
• Identity: 263/1414 - (18%)
• Similarity: 470/1414 - (33%)
• Gaps: 425/1414 - (30%)

Human  1760 ESRGENEEMEKDLREKLADYKNKV--DDAWDLLREATDKIREANRLFAVNQKNMTALEKKKEAVE 1822
            :.||:::  |..|.:|.|.:..|:  ||....:.::|                 .||...:.|..
  Fly    93 DGRGKSD--EDVLYQKGASFSAKLANDDGGKSMAKST-----------------FALSAAQSASP 138

Human  1823 SGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLA 1887
            :|....|          ||:....|.    .||            .||.|...: :||.|.:.|.
  Fly   139 AGNENGE----------DESGSEGDS----YDY------------GELEDSNSE-TQEQKQKSLN 176

Human  1888 EKVSQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFKAYSNIKDYIDEAEKVAKEAKDLAHEA 1952
            .:..|.:......||       ....|::|:||:.:..:...::.|:...:..:..........:
  Fly   177 LQQQQQQQQKVNSND-------YYISAESINFNSESEGQEQQDVADFKAASTMLPSSVPPTPSRS 234

Human  1953 TKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKENE-----DHLNGLKTRIENADARNGDL 2012
            |..||..........:       |....|.|...||...|     |:....|:.:...|..|.:.
  Fly   235 TTRATASTTTTTTTTR-------RSPTRAPKQRVDVDYGEGDGSDDYSYSYKSDMSVYDDVNNNQ 292

Human  2013 LRTLNDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVA 2077
            |....::..:.....::|    ...|::.:..|.|:..|...||          :..|:|.:..|
  Fly   293 LNLRRNSKSQTYQQTSNT----NTAKNRRKYPNVTSNKVQMHIT----------RETNRLENISA 343

Human  2078 KTNAVVKDPSKNKIIADADATVKNLEQEADRLIDKLKPIKELEDNLKKNISEIKELINQARKQAN 2142
            ...|||    ...:..|......||:..:|.:.                      .:......:.
  Fly   344 AEPAVV----GAAMTTDRSTPTCNLDCGSDGIC----------------------ALEATAASSR 382

Human  2143 SIKVSVSSGGDC---IRTYKPEIKK----------GSYNNIVVNV--KTAVADNLLFYLGSAKFI 2192
            .:.....:|..|   ||.:.|...|          |:|.::.:.:  :....|.::...|....:
  Fly   383 CLCPFGKTGNGCQEDIRAHVPRFAKRSWLAFPALHGAYKHVQLRIEFRPESFDGIILLSGERDDL 447

Human  2193 --DFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASI 2255
              ||:|:.:.||.|.|.:|.|||||.|...: ||..:.|..::..|...:..:.:
  Fly   448 TGDFMALLLNKGFVEFWFDCGSGVGSVRSRE-TILLNEWNSVIIYRHRWDAWLVL---------- 501

Human  2256 VPSTHHSTSPPGYT---ILDVDANAMLFVGG---LTGKLKKADAVRVITFTGCM-------GETY 2307
                :|.|...|.:   ...:.....:|:||   :||..|:.....  .|.||:       .:..
  Fly   502 ----NHGTKVQGRSNGLFSRITFREPVFLGGIGNITGLAKRLPLAE--GFAGCIRRFVANEHDYK 560

Human  2308 FDNKPIG--LWNFREKEGDCKGCTVSPQVE-----------DSEGTI------------------ 2341
            |...|:|  :..|     |.:.|:....|.           ..:|.|
  Fly   561 FTEHPLGDVINGF-----DIQDCSTDKCVRYPCQHGGKCLPSDQGAICLCPIGFVGDLCEIRMDL 620

Human  2342 ---QFDGEGYALVSRPIRWYPNISTVMF------KFRTFSSSALLMYLATRDLRDFMSVELTDGH 2397
               .|:|..:      :|:.|...:.:.      ..:...:..|::|.......||:::.|.||.
  Fly   621 QVPAFNGSSF------LRYAPLGDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGF 679

Human  2398 IKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDL 2462
            ::.::|||||.|.|.|..:.:.|:|.:..:||   .|.::::.:|.:||  :.|.||...:.|.|
  Fly   680 VEFAFDLGSGPALVRSEHSLSLGQWHTIKISR---TARLAVLKVDKHQE--VLTISSNGFWHLSL 739

Human  2463 KADDKIYFGG------LPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSS---------- 2511
              |..::.||      ||    |.:|.:|     .:.||::.|:|:.....|::.
  Fly   740 --DQNLFVGGVNHVDRLP----LDLKYKP-----FFVGCIQRIDINGHSLGIVAEALGGSNIGNC 793

Human  2512 ----------------PDYVGVTKGCSLENV---YTVSFPKPGFVELS----------------- 2540
                            |........||:.|.   .....|.....||:
  Fly   794 PHACVARPCGPLAECVPQMESYECRCSIHNERCNKAAEVPPEQLPELALHKSKVLETKDNGEAAK 858

Human  2541 -------------------PVPIDVGTEINLSFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYY 2586
                               |.|....|....|.:|..           |.||..|....|..|
  Fly   859 KVSGLAHKKHSKKHRNLHKPTPATSTTTSTTSTTTTT-----------TEAPSERTEEATAGA-- 910

Human  2587 AILLNRGRLEVHL--------------------------STGARTMRKIVIRPEPNLFHDGREHS 2625
               |:...:|..:                          :|...:......:|..:..|...:|.
  Fly   911 ---LSNEEIEDDIIFRLVQQQQQQKELKKQHQQTTTTAPATSTTSSGPSKAKPRLSGKHHASKHE 972

Human  2626 VHVERTRGIFT---------------------VQVDENRRYMQNLTVEQ------PIEVKKLFVG 2663
            .|: :....||                     :..::|..::.:|..::      ..:|...|..
  Fly   973 HHL-KPNAAFTRKLSRLPTHYESFQTNPDSDILTFEDNNDWVTSLQQQEYGDAMAASQVPLAFED 1036

Human  2664 GAPPEFQPSPL----RNIPPFEGCIWNLVINS-------VPMDFARPVSFKNADIGRCAHQKLR- 2716
            .:|...:.|..    .|...|:..:::....:       :..|..|.:|..||   ..:|:|..
  Fly  1037 ASPGTPRSSDNNEDDENAFVFDESLFDASDGTEEYQRKQLAQDMKRIMSNSNA---HSSHKKAEV 1098

Human  2717 ------------------------EDEDGAAPA-----EIVIQPEPVPTPAFPTPTPVLTHGPCA 2752
                                    .|::...|.     |:.::.....||...|...:|.....:
  Fly  1099 QFPPQGSQEVGTANEDTSQYSDDYNDDELLTPVMQGGEEVKLEQHTSSTPQTHTDWSLLKKFDLS 1163

Human  2753 AESEPALLIGSKQFG---LSRNSHIAIAFDDTK---VKNRLTIELEVRTEAESGLLFYMAR---- 2807
            ||.:..:....|.||   ...:|:......||.   :...:.:.|.::|.:|:|::.:..|
  Fly  1164 AEHQSQVQGVRKNFGACFAGSDSYFHYNDADTMSQVISYSIDLNLRIKTHSENGVILWTGRQGTT 1228

Human  2808 INHADFATVQLRNGLPYFSYDLGSGDTHTMI-PTKINDGQWHKIKIMRSKQEGILYVDGASNRTI 2871
            ..|.|:.::.:..|..:|.||||||:..... .||::||.||:::.:|:.|||.|.|||....|:
  Fly  1229 EEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGRKTVTL 1293

Human  2872 -SPKKADILDVVGMLYVGGLP-INYTTRRIGPVTY--SIDGCVRNLHMA 2916
             :|.|...|:....|||||:| :.|.|.:    .|  .|.||:..:.:|
  Fly  1294 RAPGKLRQLNTDTGLYVGGMPDVGYFTHQ----RYFSGIVGCISEIVLA 1338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LAMA2	NP_000417.3	LamNT	37..285	CDD:214532
		EGF_Lam	287..334	CDD:238012
		Laminin_EGF	414..471	CDD:395007
		Laminin_EGF	469..515	CDD:395007
		LamB	578..710	CDD:214597
		EGF_Lam	756..805	CDD:238012
		Laminin_EGF	807..862	CDD:395007
		EGF_Lam	864..916	CDD:238012
		EGF_Lam	917..965	CDD:238012
		EGF_Lam	967..1011	CDD:214543
		EGF_Lam	1014..1057	CDD:214543
		Laminin_EGF	1060..1108	CDD:395007
		Laminin_EGF	1106..1163	CDD:395007
		LamB	1229..1364	CDD:214597
		Laminin_EGF	1420..1466	CDD:395007
		Laminin_EGF	1469..1524	CDD:395007
		EGF_Lam	1527..1574	CDD:238012
		Domain II and I	1574..2144		66/390 (17%)
		Laminin_I	1593..1852	CDD:310534	18/93 (19%)
		SMC_prok_B	1718..>2077	CDD:274008	58/323 (18%)
		Laminin_II	2037..2173	CDD:368703	24/148 (16%)
		Laminin_G_1	2174..2314	CDD:395008	34/156 (22%)
		Laminin_G_1	2368..2507	CDD:395008	40/144 (28%)
		Laminin_G_1	2554..2695	CDD:395008	24/204 (12%)
		Laminin_G_1	2793..2921	CDD:395008	45/133 (34%)
		LamG	2941..3093	CDD:238058
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3043..3063
SP2353	NP_611082.2	FXa_inhibition	53..82	CDD:464251
		LamG	404..555	CDD:238058	35/167 (21%)
		EGF	583..612	CDD:394967	3/28 (11%)
		LamG	625..774	CDD:238058	43/170 (25%)
		LamG	1205..1340	CDD:214598	46/138 (33%)