Protein Alignment LAMA2 and NetA

DIOPT Version :9

• Sequence 1: XP_016866340.1
• Gene: LAMA2 / 3908
• HGNCID: 6482
• Length: 3212
• Species: Homo sapiens
• Sequence 2: NP_001285243.1
• Gene: NetA / 32398
• FlyBaseID: FBgn0015773
• Length: 726
• Species: Drosophila melanogaster
• Alignment Length: 683
• Identity: 178/683 - (26%)
• Similarity: 286/683 - (41%)
• Gaps: 141/683 - (20%)

Human    33 AHELRARGLFPAVLNLASNALITTNATCGEKGPEMYCKLVEHVPGQPVRNPQCRICNQNSSNPNQ 97
            |||.||  ..|..:|.|.:|.:..::|||..|.:.||:..:|       ...|..|:.  ::|.:
  Fly    44 AHEPRA--CIPDFVNAAYDAPVVASSTCGSSGAQRYCEYQDH-------ERSCHTCDM--TDPLR 97

Human    98 RHPITNAIDGKN----TWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVK-AANSPRPGNWILE 157
            ..|..:..|..|    |.|:|..:....:  .||:||.|.:.|::.|||:: ..::|||.:.::.
  Fly    98 SFPARSLTDLNNSNNVTCWRSEPVTGSGD--NVTLTLSLGKKFELTYVILQLCPHAPRPDSMVIY 160

Human   158 RSLD-DVEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHISLI 221
            :|.| .:.::|:|:.:   ::|..|:. .|.........:.|..|:..   ..||.: .|..|.:
  Fly   161 KSTDHGLSWQPFQFFS---SQCRRLFG-RPARQSTGRHNEHEARCSDV---TRPLVS-RIAFSTL 217

Human   222 NGRPSAD--DPSPELLEFTSARYIRLRFQRIR--------TLNA----DLMMFAHKDPREIDP-- 270
            .||||:.  |.||.|.::.:|..||:.|.|::        :|.|    ||....:..|....|
  Fly   218 EGRPSSRDLDSSPVLQDWVTATDIRVVFHRLQRPDPQALLSLEAGGATDLASGKYSVPLANGPAG 282

Human   271 ----------IVT--RRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQC 323
                      :.|  ...:|::.|.||||.|.|.|||..|..| |:.:..|||.|||.|..|::|
  Fly   283 NNIEANLGGDVATSGSGLHYAISDFSVGGRCKCNGHASKCSTD-ASGQLNCECSHNTAGRDCERC 346

Human   324 CPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTA 388
            .|....:||...|.....||:.|||:..|.:|.::..:.|.:       :.:.||||.||..:|.
  Fly   347 KPFHFDRPWARATAKEANECKECNCNKHARQCRFNMEIFRLS-------QGVSGGVCQNCRHSTT 404

Human   389 GINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGV 453
            |.||..|.:||:|.......:.:.|:.|.|.||||..::|         ....|.|.||.|..|:
  Fly   405 GRNCHQCKEGFYRDATKPLTHRKVCKACDCHPIGSSGKIC---------NSTSGQCPCKDGVTGL 460

Human   454 SCDRCARGYTGYPDCKACNCSGLGSKNEDPCFGPCICK----------ENV------------EG 496
            :|:||||||                :.......|||.:          :|.            .|
  Fly   461 TCNRCARGY----------------QQSRSHIAPCIKQPPRMINMLDTQNTAPEPDEPESSPGSG 509

Human   497 GDCS-----RCKSGFFNLQEDNWKGCDECFCS----GVSNRCQSSYWTYGKI--QDMSGWYLTDL 550
            ||.:     ..:|.::  :.:..:.|.:|..|    .::..|:..|....|:  :|.|...::..
  Fly   510 GDRNGAAGMAAQSQYY--RTEGGRECGKCRVSTKRLNLNKFCKRDYAIMAKVIGRDTSSEAVSRE 572

Human   551 PGRIRVAPQQDDLDSPQQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEE 615
            ..|..:.|...|.:..|   :....||..:...|.:.| |.| .|..|...|.         |.|
  Fly   573 VQRRAMDPDVADYEMDQ---VQPGSARSPITGVYEFQA-ADY-PNPNPNPRGS---------EME 623

Human   616 EEDTERVLQLMIILEGNDLSISTAQDEVYLHPS 648
            ..|    ||:..:.:.:....|:....||..|:
  Fly   624 RFD----LQIQAVFKRSRPGESSGAGNVYGMPN 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LAMA2	XP_016866340.1	None
NetA	NP_001285243.1	LamNT	44..280	CDD:214532	68/256 (27%)
		EGF_Lam	312..357	CDD:238012	20/45 (44%)
		EGF_Lam	369..426	CDD:238012	20/63 (32%)
		EGF_Lam	431..479	CDD:238012	20/72 (28%)
		NTR_netrin-1_like	545..723	CDD:239634	27/126 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910