DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LAMA2 and nsp1

DIOPT Version :9

Sequence 1:XP_016866340.1 Gene:LAMA2 / 3908 HGNCID:6482 Length:3212 Species:Homo sapiens
Sequence 2:NP_594158.1 Gene:nsp1 / 2542668 PomBaseID:SPAC26A3.15c Length:598 Species:Schizosaccharomyces pombe


Alignment Length:556 Identity:110/556 - (19%)
Similarity:162/556 - (29%) Gaps:169/556 - (30%)


- Green bases have known domain annotations that are detailed below.


Human  1493 SQPGGRT--------------PGPTLGTCVPCQCNGHSSLCDP-ETSICQNCQHHTAGDFCERCA 1542
            :.|.|.|              |..|..|..|...:..|....| .|....|..  .|.......|
pombe   134 TNPSGSTFNFGSSNNSFNFGKPASTTNTTTPAAASTGSLFGKPAATGTTSNAP--PASSTSTTPA 196

Human  1543 LGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRGYE-GQYCERCAPG---- 1602
            .|..|...|.|..        :.|:||.|.|..|..           |:. |:.....|||    
pombe   197 TGSGGFSFGKPAS--------LGSTNNASTSTTANS-----------GFSFGKPATTSAPGSNTT 242

Human  1603 YTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRP-----------GATGRKCDGCKHWHAR 1656
            .|.|....|.:..:......||.     |.|||...:|           |.|.....|       
pombe   243 VTPSSSITGTNDSKPAASNTGSA-----PTTGFSFGKPAGQAASTATDKGTTTTSSAG------- 295

Human  1657 EGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQELKHLLS---PQRA 1718
                        ||...|..|..|.       |....||..........|.:.|...|   ..:.
pombe   296 ------------TGFSFGKPATTED-------TNKPTAPNSAFTKPATSTGDNKPTFSFGNTSKP 341

Human  1719 PERLIQLAEGNLNTLVTEMNELLTRATKVTADGEQT------GQDAERTNTRAKSLGEFIKELAR 1777
            .|        |.:|..|.... |:..||......||      |:.|..|.|.....|........
pombe   342 TE--------NTSTTATSAPP-LSNNTKPAEGANQTSSGFSFGKPATDTTTSTSKTGPLFGNKPA 397

Human  1778 DAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIA----------ED 1832
            |..|      |...|..|...  |.....::.:..|.|......:|.||.|:.          :.
pombe   398 DPSA------KPGATASTTPS--EPPPSSIKHKTLQEILNKWSTDLTTQTEVFNKLCDQVSDWDR 454

Human  1833 ELVAAEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVN 1897
            .||...||   :.||:.|: .|.|:|           .|::||..:.:..:..:      ||   
pombe   455 TLVDNGAL---ISKLYTET-VEAEQM-----------SNRIDDGLEYVSSSQQE------LF--- 495

Human  1898 QKNMTALEKKKEAVESGKRQIENTLKE-----GNDILDEANRLADEINSIIDYVEDIQTKLPPMS 1957
             |.:.:.|.:.|..:.......|..:|     .:|||...:||.:::.::|:.:.|.......:|
pombe   496 -KLLDSYETQLETFDGRATSALNVERERAFGVADDILSRLDRLGEDLGTVINQMNDFSKPDDSIS 559

Human  1958 E--------------------ELNDKIDDLSQEIKD 1973
            |                    ::.:|:|.:.::..|
pombe   560 EIVKVLNAQLASLGWVENRIFQMEEKLDTIKKKNSD 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LAMA2XP_016866340.1 None
nsp1NP_594158.1 Nsp1_C 407..520 CDD:282867 27/139 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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