DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4080 and MARCHF11

DIOPT Version :9

Sequence 1:	NP_001246695.1	Gene:	CG4080 / 39079	FlyBaseID:	FBgn0035983	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_001096032.1	Gene:	MARCHF11 / 441061	HGNCID:	33609	Length:	402	Species:	Homo sapiens

Alignment Length:	274	Identity:	64/274 - (23%)
Similarity:	103/274 - (37%)	Gaps:	99/274 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GSGSSQAS---QNSGDICRICHCESDPQNPLLTPCYCSGSLKYVHQACLQQWLTASETNSCELCK 90
            |.|..:|.   |:...||:||. :...|..||.||.|.||::|.||.||.:|::...:.:||||.
Human   153 GGGDQRAGHQHQHHQPICKICF-QGAEQGELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCC 216

  Fly    91 FPF-IMHTKIKPFNEWRSLDISGIERRRLCYSV---LFHCAAALCVIWSLCVLIERAADDVQRGL 151
            :.: ::..|:|...:|:|:.|:.:|:.::...:   ||..|:...::||              ..
Human   217 YRYHVIAIKMKQPCQWQSISITLVEKVQMIAVILGSLFLIASVTWLLWS--------------AF 267

  Fly   152 IDWPFWTK---LAVVTVGLTGGIVFMYIQC--------KAYLHLCHRWKA--------------- 190
            ..:..|.:   |..:..|:.|   ||.:.|        .|...:..||:|
Human   268 SPYAVWQRKDILFQICYGMYG---FMDLVCIGLIVHEGAAVYRVFKRWRAVNLHWDVLNYDKATD 329

  Fly   191 ----------------------RNRILLIQNAPEKIHPVAPPSP------VAAH-------HQHF 220
                                  |||.|        :||....||      |..|       |:..
Human   330 IEESSRGESSTSRTLWLPLTALRNRNL--------VHPTQLTSPRFQCGYVLLHLFNRMRPHEDL 386

  Fly   221 SEPLAHAGSTSGAV 234
            ||     .::||.|
Human   387 SE-----DNSSGEV 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4080	NP_001246695.1	RINGv	42..90	CDD:128983	21/47 (45%)
MARCHF11	NP_001096032.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..161		3/7 (43%)
		RINGv	169..215	CDD:128983	20/46 (43%)
		YXXL motif	371..374		1/2 (50%)
		PDZ-binding	399..402
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810