DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4080 and MARCHF8

DIOPT Version :9

Sequence 1:	NP_001246695.1	Gene:	CG4080 / 39079	FlyBaseID:	FBgn0035983	Length:	617	Species:	Drosophila melanogaster
Sequence 2:	NP_001269795.1	Gene:	MARCHF8 / 220972	HGNCID:	23356	Length:	573	Species:	Homo sapiens

Alignment Length:	168	Identity:	94/168 - (55%)
Similarity:	129/168 - (76%)	Gaps:	4/168 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SGDICRICHCESDPQNPLLTPCYCSGSLKYVHQACLQQWLTASETNSCELCKFPFIMHTKIKPFN 103
            |||:|||||||.|.::||:|||:|:|||.:|||||||||:.:|:|..|||||:.|||.||:||..
Human   358 SGDVCRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLR 422

  Fly   104 EWRSLDISGIERRRLCYSVLFHCAAALCVIWSLCVLIERAADDVQR----GLIDWPFWTKLAVVT 164
            :|..|.::..|||::..||.||..|..||:|||.|||:|.|:::::    |:::|||||||.||.
Human   423 KWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVA 487

  Fly   165 VGLTGGIVFMYIQCKAYLHLCHRWKARNRILLIQNAPE 202
            :|.|||::|||:|||.|:.|..|.||.||::.:||.||
Human   488 IGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4080	NP_001246695.1	RINGv	42..90	CDD:128983	31/47 (66%)
MARCHF8	NP_001269795.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..72
MARCHF8	NP_001269795.1	RINGv	361..409	CDD:128983	31/47 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160217
Domainoid	1	1.000	87	1.000	Domainoid score	I8014
eggNOG	1	0.900	-	-		E1_COG5183
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001979
OrthoInspector	1	1.000	-	-		otm40944
orthoMCL	1	0.900	-	-		OOG6_106356
Panther	1	1.100	-	-	O	PTHR45981
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R328
SonicParanoid	1	1.000	-	-		X270
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.770