DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp27 and Hspb6

DIOPT Version :9

Sequence 1:	NP_001287001.1	Gene:	Hsp27 / 39078	FlyBaseID:	FBgn0001226	Length:	213	Species:	Drosophila melanogaster
Sequence 2:	NP_620242.1	Gene:	Hspb6 / 192245	RGDID:	621554	Length:	162	Species:	Rattus norvegicus

Alignment Length:	161	Identity:	59/161 - (36%)
Similarity:	76/161 - (47%)	Gaps:	34/161 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GHLLEDDFGFGVHAHDLFHPRRLLLPNTLGLGRRRYSPYERSHGHHNQMSRRASGGPNALLPA-- 84
            |.|.:..||.|:...:|    ..|.|..:       :||          ..||   |:..||.
  Rat    26 GRLFDQRFGEGLLEAEL----ASLCPAAI-------APY----------YLRA---PSVALPTAQ 66

  Fly    85 VGKDG--FQVCMDVSQFKPNELTVKVVDNTVVVEGKHEEREDGHGMIQRHFVRKYTLPKGFDPNE 147
            |..|.  |.|.:||..|.|.|::||||.:.|.|..:||||.|.||.|.|.|.|:|.||.|.||..
  Rat    67 VPTDPGYFSVLLDVKHFSPEEISVKVVGDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAA 131

  Fly   148 VVSTVSSDGVLTLKAPPP------PSKEQAK 172
            |.|.:|.:|||:::|.|.      ||...||
  Rat   132 VTSALSPEGVLSIQATPASAQASLPSPPAAK 162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp27	NP_001287001.1	metazoan_ACD	86..163	CDD:107247	37/78 (47%)
Hspb6	NP_620242.1	Involved in stabilization of the HSPB1:HSBP6 heterodimer. /evidence=ECO:0000250\|UniProtKB:O14558	1..72		17/69 (25%)
		Crystallin	3..58	CDD:395419	12/55 (22%)
		ACD_HspB4-5-6	66..148	CDD:107233	39/81 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.850