DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp27 and Hspb2

DIOPT Version :9

Sequence 1:	NP_001287001.1	Gene:	Hsp27 / 39078	FlyBaseID:	FBgn0001226	Length:	213	Species:	Drosophila melanogaster
Sequence 2:	NP_569115.1	Gene:	Hspb2 / 161476	RGDID:	70914	Length:	182	Species:	Rattus norvegicus

Alignment Length:	183	Identity:	57/183 - (31%)
Similarity:	83/183 - (45%)	Gaps:	50/183 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 HAH------DLFHPRRLLLPNTLGLGRRRYS----PYE-----RSHGHH--NQMSRRASG---GP 78
            |||      :..:|.|        ||.:|:.    |.|     ..||::  .:.:|...|   |.
  Rat     8 HAHPATAEYEFANPSR--------LGEQRFGEGLLPEEILTPTLYHGYYVRPRAARAGEGGRAGA 64

  Fly    79 NALLPAVGKDGFQVCMDVSQFKPNELTVKVVDNTVVVEGKHEEREDGHGMIQRHFVRKYTLPKGF 143
            :.|..:.||  ||..:|||.|.|:|:||:.|||.:.|..:|.:|.|.||.:.|.|.|.|.||...
  Rat    65 SELRLSEGK--FQAFLDVSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSREFCRTYVLPADV 127

  Fly   144 DPNEVVSTVSSDGVLTLKAP--------------------PPPSKEQAKSERI 176
            ||..|.:.:|.||:|.|:||                    ||..:|:.:..|:
  Rat   128 DPWRVRAALSHDGILNLEAPRGGRHLDTEVNEVYISLLPAPPDPEEEEEVARV 180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp27	NP_001287001.1	metazoan_ACD	86..163	CDD:107247	35/76 (46%)
Hspb2	NP_569115.1	Crystallin	<16..51	CDD:395419	9/42 (21%)
Hspb2	NP_569115.1	alpha-crystallin-Hsps_p23-like	67..148	CDD:412199	37/82 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780