DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp27 and Hspb1

DIOPT Version :9

Sequence 1:	NP_001287001.1	Gene:	Hsp27 / 39078	FlyBaseID:	FBgn0001226	Length:	213	Species:	Drosophila melanogaster
Sequence 2:	NP_038588.2	Gene:	Hspb1 / 15507	MGIID:	96240	Length:	209	Species:	Mus musculus

Alignment Length:	139	Identity:	58/139 - (41%)
Similarity:	80/139 - (57%)	Gaps:	10/139 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MSRRASGGPNALLPAVGKDGFQVCMDVSQFKPNELTVKVVDNTVVVEGKHEEREDGHGMIQRHFV 134
            ::|:.|.|.:.:....  |.::|.:||:.|.|.|||||..:..|.:.||||||:|.||.|.|.|.
Mouse    81 LNRQLSSGVSEIRQTA--DRWRVSLDVNHFAPEELTVKTKEGVVEITGKHEERQDEHGYISRCFT 143

  Fly   135 RKYTLPKGFDPNEVVSTVSSDGVLTLKAPPPPSKEQAKSERIVQIQQTGPAHLSVKAPAPEAGDG 199
            ||||||.|.||..|.|::|.:|.||::||.|.:..|:..   :.|..|..|...:  ..|||  |
Mouse   144 RKYTLPPGVDPTLVSSSLSPEGTLTVEAPLPKAVTQSAE---ITIPVTFEARAQI--GGPEA--G 201

  Fly   200 KAENGSGEK 208
            |:|. ||.|
Mouse   202 KSEQ-SGAK 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp27	NP_001287001.1	metazoan_ACD	86..163	CDD:107247	39/76 (51%)
Hspb1	NP_038588.2	Interaction with TGFB1I1. /evidence=ECO:0000250	74..209		57/137 (42%)
Hspb1	NP_038588.2	ACD_HspB1_like	88..173	CDD:107230	41/86 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820