DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp27 and HSPB6

DIOPT Version :9

Sequence 1:	NP_001287001.1	Gene:	Hsp27 / 39078	FlyBaseID:	FBgn0001226	Length:	213	Species:	Drosophila melanogaster
Sequence 2:	NP_653218.1	Gene:	HSPB6 / 126393	HGNCID:	26511	Length:	160	Species:	Homo sapiens

Alignment Length:	179	Identity:	61/179 - (34%)
Similarity:	77/179 - (43%)	Gaps:	50/179 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GHLLEDDFGFGVHAHDLFHPRRLLLPNTLGLGRRRYSPYERSHGHHNQMSRRASGGPNALLPA-- 84
            |.|.:..||.|:...:|    ..|.|.||       :||          ..||   |:..||.
Human    26 GRLFDQRFGEGLLEAEL----AALCPTTL-------APY----------YLRA---PSVALPVAQ 66

  Fly    85 VGKD--GFQVCMDVSQFKPNELTVKVVDNTVVVEGKHEEREDGHGMIQRHFVRKYTLPKGFDPNE 147
            |..|  .|.|.:||..|.|.|:.||||...|.|..:||||.|.||.:.|.|.|:|.||.|.||..
Human    67 VPTDPGHFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEHGFVAREFHRRYRLPPGVDPAA 131

  Fly   148 VVSTVSSDGVLTLKAPPPPSKEQAKSERIVQIQQTGPAHLSVKAPAPEA 196
            |.|.:|.:|||:::|.|                      .|.:||.|.|
Human   132 VTSALSPEGVLSIQAAP----------------------ASAQAPPPAA 158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp27	NP_001287001.1	metazoan_ACD	86..163	CDD:107247	36/78 (46%)
HSPB6	NP_653218.1	Involved in stabilization of the HSPB1:HSBP6 heterodimer. /evidence=ECO:0000269\|PubMed:27717639	1..72		19/69 (28%)
		Crystallin	3..58	CDD:395419	14/55 (25%)
		ACD_HspB4-5-6	66..144	CDD:107233	37/77 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140703
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X393
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950