DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp23 and Hspb6

DIOPT Version :9

Sequence 1:	NP_001246694.1	Gene:	Hsp23 / 39077	FlyBaseID:	FBgn0001224	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_001012401.1	Gene:	Hspb6 / 243912	MGIID:	2685325	Length:	162	Species:	Mus musculus

Alignment Length:	133	Identity:	55/133 - (41%)
Similarity:	65/133 - (48%)	Gaps:	33/133 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PYYCQRQRNPYLALVGPMEQQLRQLEKQVGASSGSSGAVSKIGKDGFQVCMDVSHFKPSELVVKV 89
            |||.   |.|.:||.          ..||...||.           |.|.:||.||.|.|:.|||
Mouse    52 PYYL---RAPSVALP----------TAQVSTDSGY-----------FSVLLDVKHFLPEEISVKV 92

  Fly    90 QDNSVLVEGNHEEREDDHGFITRHFVRRYALPPGYEADKVASTLSSDGVLTI---------KVPK 145
            .|:.|.|...||||.|:||||.|.|.|||.||||.:...|.|.||.:|||:|         ::|.
Mouse    93 VDDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQAQLPS 157

  Fly   146 PPA 148
            |||
Mouse   158 PPA 160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp23	NP_001246694.1	metazoan_ACD	67..145	CDD:107247	40/86 (47%)
Hsp23	NP_001246694.1	IbpA	<69..161	CDD:223149	44/89 (49%)
Hspb6	NP_001012401.1	Involved in stabilization of the HSPB1:HSBP6 heterodimer. /evidence=ECO:0000250\|UniProtKB:O14558	1..72		9/32 (28%)
		Crystallin	5..56	CDD:278926	3/6 (50%)
		ACD_HspB4-5-6	66..148	CDD:107233	44/92 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920