DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp23 and Hspb6

DIOPT Version :9

Sequence 1:	NP_001246694.1	Gene:	Hsp23 / 39077	FlyBaseID:	FBgn0001224	Length:	186	Species:	Drosophila melanogaster
Sequence 2:	NP_620242.1	Gene:	Hspb6 / 192245	RGDID:	621554	Length:	162	Species:	Rattus norvegicus

Alignment Length:	133	Identity:	53/133 - (39%)
Similarity:	63/133 - (47%)	Gaps:	33/133 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PYYCQRQRNPYLALVGPMEQQLRQLEKQVGASSGSSGAVSKIGKDGFQVCMDVSHFKPSELVVKV 89
            |||.   |.|.:||.          ..||....|.           |.|.:||.||.|.|:.|||
  Rat    52 PYYL---RAPSVALP----------TAQVPTDPGY-----------FSVLLDVKHFSPEEISVKV 92

  Fly    90 QDNSVLVEGNHEEREDDHGFITRHFVRRYALPPGYEADKVASTLSSDGVLTIK---------VPK 145
            ..:.|.|...||||.|:||||.|.|.|||.||||.:...|.|.||.:|||:|:         :|.
  Rat    93 VGDHVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQASLPS 157

  Fly   146 PPA 148
            |||
  Rat   158 PPA 160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp23	NP_001246694.1	metazoan_ACD	67..145	CDD:107247	39/86 (45%)
Hsp23	NP_001246694.1	IbpA	<69..161	CDD:223149	43/89 (48%)
Hspb6	NP_620242.1	Involved in stabilization of the HSPB1:HSBP6 heterodimer. /evidence=ECO:0000250\|UniProtKB:O14558	1..72		9/32 (28%)
		Crystallin	3..58	CDD:395419	4/8 (50%)
		ACD_HspB4-5-6	66..148	CDD:107233	42/92 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920