DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp26 and Hspb6

DIOPT Version :9

Sequence 1:	NP_001287000.1	Gene:	Hsp26 / 39075	FlyBaseID:	FBgn0001225	Length:	208	Species:	Drosophila melanogaster
Sequence 2:	NP_620242.1	Gene:	Hspb6 / 192245	RGDID:	621554	Length:	162	Species:	Rattus norvegicus

Alignment Length:	132	Identity:	50/132 - (37%)
Similarity:	64/132 - (48%)	Gaps:	26/132 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 CPCASPICPSSPAGQVLALRREMANRNDIHWPATAHVGKDG--FQVCMDVAQFKPSELNVKVVDD 110
            ||.|  |.|.......:||             .||.|..|.  |.|.:||..|.|.|::||||.|
  Rat    46 CPAA--IAPYYLRAPSVAL-------------PTAQVPTDPGYFSVLLDVKHFSPEEISVKVVGD 95

  Fly   111 SILVEGKHEERQDDHGHIMRHFVRRYKVPDGYKAEQVVSQLSSDGVLTV---------SIPKPQA 166
            .:.|..:||||.|:||.|.|.|.|||::|.|.....|.|.||.:|||::         |:|.|.|
  Rat    96 HVEVHARHEERPDEHGFIAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQATPASAQASLPSPPA 160

  Fly   167 VE 168
            .:
  Rat   161 AK 162

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp26	NP_001287000.1	metazoan_ACD	85..163	CDD:107247	37/88 (42%)
Hsp26	NP_001287000.1	IbpA	<87..179	CDD:223149	40/93 (43%)
Hspb6	NP_620242.1	Involved in stabilization of the HSPB1:HSBP6 heterodimer. /evidence=ECO:0000250\|UniProtKB:O14558	1..72		11/40 (28%)
		Crystallin	3..58	CDD:395419	5/13 (38%)
		ACD_HspB4-5-6	66..148	CDD:107233	37/81 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	1	1.000	-	-		FOG0000383
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45640
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920