Protein Alignment CG4461 and HSPB1

DIOPT Version :10

• Sequence 1: NP_648304.1
• Gene: CG4461 / 39074
• FlyBaseID: FBgn0035982
• Length: 200
• Species: Drosophila melanogaster
• Sequence 2: NP_001531.1
• Gene: HSPB1 / 3315
• HGNCID: 5246
• Length: 205
• Species: Homo sapiens
• Alignment Length: 172
• Identity: 49/172 - (28%)
• Similarity: 70/172 - (40%)
• Gaps: 49/172 - (28%)

  Fly    35 WDDSRLWWPSPHTSRSDLLRPLDELVSRRVRNQLIQSTPYEWAHPM---RWDNY----------- 85
            ||..|.|:  ||:...|....|..|             |.||:..:   .|..|
Human    16 WDPFRDWY--PHSRLFDQAFGLPRL-------------PEEWSQWLGGSSWPGYVRPLPPAAIES 65

  Fly    86 -------YS-----------GERVHVDEKGFRIDIDVRQFHPHDIVVKTNDDYVIVQGNHNRRDE 132
                   ||           .|..|..:: :|:.:||..|.|.::.|||.|..|.:.|.|..|.:
Human    66 PAVAAPAYSRALSRQLSSGVSEIRHTADR-WRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQD 129

  Fly   133 GSNGLVERHFVRKYLLPRGYNANEVISDISSDGILTIKAPPP 174
             .:|.:.|.|.|||.||.|.:..:|.|.:|.:|.||::||.|
Human   130 -EHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMP 170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4461	NP_648304.1	metazoan_ACD	94..169	CDD:107247	27/74 (36%)
HSPB1	NP_001531.1	Interaction with TGFB1I1. /evidence=ECO:0000250	70..205		35/103 (34%)
		ACD_HspB1_like	84..169	CDD:107230	31/86 (36%)