DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4461 and HSPB8

DIOPT Version :9

Sequence 1:	NP_648304.1	Gene:	CG4461 / 39074	FlyBaseID:	FBgn0035982	Length:	200	Species:	Drosophila melanogaster
Sequence 2:	NP_055180.1	Gene:	HSPB8 / 26353	HGNCID:	30171	Length:	196	Species:	Homo sapiens

Alignment Length:	186	Identity:	54/186 - (29%)
Similarity:	81/186 - (43%)	Gaps:	34/186 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LSREFDRLRPLYHPPYD--FQLYPYLWDDSRLWWPS----------PHTSRSDLLRPLDELVSRR 63
            |.|:..|..||.....|  |.:.|:. ||....||.          |.|.||.:: |.....:.|
Human    16 LRRDPFRDSPLSSRLLDDGFGMDPFP-DDLTASWPDWALPRLSSAWPGTLRSGMV-PRGPTATAR 78

  Fly    64 VRNQLIQSTPYEWAHPMRWDNYYSGERVHVDEKGFRIDIDVRQFHPHDIVVKTNDDYVIVQGNHN 128
            .      ..|.|...|..    :.||       .:::.::|..|.|.:::|||.|.||.|.|.|.
Human    79 F------GVPAEGRTPPP----FPGE-------PWKVCVNVHSFKPEELMVKTKDGYVEVSGKHE 126

  Fly   129 RRDEGSNGLVERHFVRKYLLPRGYNANEVISDISSDGILTIKAPPPPPAKYYTPGE 184
            .:.: ..|:|.::|.:|..||...:...|.:.:|.:|:|.|:||..||  |.|.||
Human   127 EKQQ-EGGIVSKNFTKKIQLPAEVDPVTVFASLSPEGLLIIEAPQVPP--YSTFGE 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4461	NP_648304.1	metazoan_ACD	94..169	CDD:107247	22/74 (30%)
HSPB8	NP_055180.1	ACD_HspB8_like	80..170	CDD:107235	29/101 (29%)
HSPB8	NP_055180.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..196		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1187096at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820