Protein Alignment Klp67A and KIP2

DIOPT Version :9

• Sequence 1: NP_001286999.1
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_015170.1
• Gene: KIP2 / 855948
• SGDID: S000006076
• Length: 706
• Species: Saccharomyces cerevisiae
• Alignment Length: 652
• Identity: 190/652 - (29%)
• Similarity: 286/652 - (43%)
• Gaps: 136/652 - (20%)

  Fly    11 VAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLTM--- 72
            :.|.:||        |.||:....|...|......:.......|:....||.....|.|..:
Yeast   103 ITVTIRP--------KPRSVGTSRDHVGLKSPRYSQPRSNSHHGSNTFVRDPWFITNDKTIVHEE 159

  Fly    73 ----EFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYL 133
                :||.||....:|.:::|..:.|::|.:|.|:|.::|.||.||:||||||.|:|...||..|
Yeast   160 IGEFKFDHVFASHCTNLEVYERTSKPMIDKLLMGFNATIFAYGMTGSGKTFTMSGNEQELGLIPL 224

  Fly   134 TMQDLFDKIQAQS--DVRKFDVGVSYLEVYNEHVMNLL-------------------TKSG---- 173
            ::..||..|..||  ..:||||.:||||:|||.:.:||                   :||.
Yeast   225 SVSYLFTNIMEQSMNGDKKFDVIISYLEIYNERIYDLLESGLEESGSRISTPSRLYMSKSNSNGL 289

  Fly   174 --PLKLREDNN-GVVVSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRI 235
              .||:|:|:. ||.|.||......|:|||||.:.:|:..|....||.||.|||||||..:.:..
Yeast   290 GVELKIRDDSQYGVKVIGLTERRCESSEELLRWIAVGDKSRKIGETDYNARSSRSHAIVLIRLTS 354

  Fly   236 TERKTDTKRTVKLSMIDLAGSERAASTKGIGVRFKEGASINKSLLALGNCINKL-ADGL------ 293
            |..|..|.|:..||:.||||||||.   |...|.|||:.|||||||||..|:|| ||.:
Yeast   355 TNVKNGTSRSSTLSLCDLAGSERAT---GQQERRKEGSFINKSLLALGTVISKLSADKMNSVGSN 416

  Fly   294 ------------------------KHIPYRDSNLTRILKDSLGGNCRTLMVANVSMSSLTYEDTY 334
                                    .|||||||.|||:|:.:|.|:.....:..|...:....:|.
Yeast   417 IPSPSASGSSSSSGNATNNGTSPSNHIPYRDSKLTRLLQPALSGDSIVTTICTVDTRNDAAAETM 481

  Fly   335 NTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALEAKATQLERAGNSG 399
            |||::|||||.:...:.:..:.|....:....:..|::  ..:|:|:.:.:    ::|:...|.|
Yeast   482 NTLRFASRAKNVALHVSKKSIISNGNNDGDKDRTIELL--RRQLEEQRRMI----SELKNRSNIG 540

  Fly   400 FDPLELKTWYSKIDAVYAAARQLQEHVLGMRSKIKNINYRQTLKKELEEFRKLMCVDQRVCQEDF 464
             :||...:..|....:.|.......::..||::      .:.||.:||...||:..|....|:
Yeast   541 -EPLTKSSNESTYKDIKATGNDGDPNLALMRAE------NRVLKYKLENCEKLLDKDVVDLQD-- 596

  Fly   465 RRFANYMSTLTSQMEKYKEELPSWL-SKMEIAYQDLESLKREVNKSKAYQILIVYVKYKDLELQL 528
                       |::.:..|.||..: :.:|..:|.|||..|:            |.||
Yeast   597 -----------SEIMEIVEMLPFEVGTLLETKFQGLESQIRQ------------YRKY------- 631

  Fly   529 TKQNIFNNHVNAINQELVENLDLMRKSFRTACEVLNQTYDRLEDGQKLTPEIEAVFERLLRKMRF 593
                         .|:|.:.:..:.||..||..:.......:.:.||:....:.:.|.|....|.
Yeast   632 -------------TQKLEDKIMALEKSGHTAMSLTGCDGTEVIELQKMLERKDKMIEALQSAKRL 683

  Fly   594 AD 595
            .|
Yeast   684 RD 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	144/407 (35%)
		KISc_KIP3_like	8..346	CDD:276821	144/400 (36%)
KIP2	NP_015170.1	KISc_CENP_E	102..493	CDD:276825	144/400 (36%)
		SMC_prok_B	<445..>698	CDD:274008	66/299 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810