Protein Alignment Klp67A and KIP3

DIOPT Version :9

• Sequence 1: NP_001286999.1
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_011299.1
• Gene: KIP3 / 852655
• SGDID: S000003184
• Length: 805
• Species: Saccharomyces cerevisiae
• Alignment Length: 854
• Identity: 250/854 - (29%)
• Similarity: 394/854 - (46%)
• Gaps: 197/854 - (23%)

  Fly     1 MPSEQHTNIKVAVRVRPYNVRE------------------------------------------- 22
            :|..:.::|.||:||||:...|
Yeast     3 VPETRQSSIVVAIRVRPFTSMEKTRLVNEASGAEANFPGLGDSSLILPMSNNSDSDIDIDAEEGS 67

  Fly    23 --------LEQKQ------RSIIKVMDRSALLFDPDEED------DEFF---------------- 51
                    |.:|.      |.|:..:|...|:|||.:.:      |:..
Yeast    68 TRSKRNSLLRRKVIRPEGIRKIVDCVDDRMLIFDPADRNPLNKVSDQVLNSMRARATKATASSIN 132

  Fly    52 FQGAKQPYRDITKRMNKKLTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAG 116
            ...|...:....:|...::...||::||..:|...:::|.|:||:|:||:|:|.:||.|||||.|
Yeast   133 NSNATNKFSSQRRRHGGEIKFVFDKLFDETSSQARVYKETTSPLLDSVLDGFNSTVFAYGATGCG 197

  Fly   117 KTFTMLGSEAHPGLTYLTMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLL---TKSGPLKLR 178
            ||:|:.|:.:.||:.:|.|::||:||....|.:.|::.:||||:|||.:.:||   |.|..|.:|
Yeast   198 KTYTVSGTPSQPGIIFLAMEELFNKITDLKDEKDFEISLSYLEIYNERIRDLLKPETPSKRLVIR 262

  Fly   179 ED-NNGVVVSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTD- 241
            || .|.:.|:.|......:.|:::.:::.||.:||..||:||..||||||:.|:||..|.:..|
Yeast   263 EDTQNHIKVANLSYHHPNTVEDVMDLVVQGNINRTTSPTEANEVSSRSHAVLQIHIMQTNKLVDL 327

  Fly   242 -TKRT-VKLSMIDLAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLA--DGLK--HIPYRD 300
             ::.| ..||:||||||||||:|:..|:|..|||:||:||||||||||.|.  ||.:  ||||||
Yeast   328 TSQHTFATLSIIDLAGSERAAATRNRGIRLHEGANINRSLLALGNCINALCLNDGSRSCHIPYRD 392

  Fly   301 SNLTRILKDSLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYV 365
            |.|||:||.||||||:|:|:..:|.||..|::|.||||||:|||:|:|.:.:|..........|:
Yeast   393 SKLTRLLKFSLGGNCKTVMIVCISPSSSHYDETLNTLKYANRAKEIKTKIIRNQQSLSRHVGSYL 457

  Fly   366 KKIDEVVAENERLKER-NKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYA------AARQLQ 423
            |.|.|...:.|.|:|| .|.:..|.|:.:.  |.....|.:....:::...||      .|:.|:
Yeast   458 KMITEQKRQIEELREREEKMISLKLTKYKL--NKEKIQLAINECVNRVQQTYAGVETYQVAKTLK 520

  Fly   424 EHVLGMRSKIKNINYRQTLKKELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSW 488
            ..:|..|      .:.|.:|.|::....|...::....|        |..:.|.......:|.:.
Yeast   521 SLILCKR------RFLQMVKLEVDNLILLFEREESTAAE--------MQPVISNCRMISGQLYNK 571

  Fly   489 LSKMEIAYQDLESLKR--------EVNK-------SKAYQILIVYVKYKDLELQLTKQNIFNNHV 538
            :.::|:.:.:.::|..        ::||       .:.|.  :||::
Yeast   572 IHELEMKFDETDTLSSVIHQVHSIDLNKLREMEDWDETYD--LVYLE------------------ 616

  Fly   539 NAINQ--ELVENLDLMRKSFRT----ACEVLNQTYDRLEDG-QKLTPEIEAVFERLLRKMRFADS 596
            :.:||  ||..|..|:..|..|    :...||..:..|... ...||.||::.:.|:......:|
Yeast   617 SCLNQISELQRNEILVNSSIMTEKLMSDPGLNSRFKFLSKWLMNRTPNIESIIQDLVHIDEEFES 681

  Fly   597 EANTKMAEMNP------------------LAVPVAL--RSSAQEEEEPTCSLTASAKKRQRQAAQ 641
            .|.|.:|  ||                  ||||...  |.:..:::....|...|.........:
Yeast   682 FARTFIA--NPDSNFTNTNINIINTTAADLAVPAETLQRQNFSQKKVKWTSPDLSPSPMIEPQPE 744

  Fly   642 SDDDLHLSMEDFDSQDTESDSEELHRTFKRPRNLNETQVLGPCSSSSSSSTS-------SSSSAR 699
            .:.:||   :|.|:..:|.|......||      ||.   || |:.|:.:|:       ||....
Yeast   745 LEPELH---QDQDAIASEVDVSMQDTTF------NEQ---GP-STPSAPTTAVPRRKMRSSLLTH 796

  Fly   700 KALTATVTK 708
            ::|.||..|
Yeast   797 QSLLATARK 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	164/434 (38%)
		KISc_KIP3_like	8..346	CDD:276821	162/427 (38%)
KIP3	NP_011299.1	KISc_KIP3_like	82..438	CDD:276821	152/355 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344890
Domainoid	1	1.000	268	1.000	Domainoid score	I283
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	285	1.000	Inparanoid score	I547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	1	1.000	-	-		oto99207
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	1	1.000	-	-		X1854
TreeFam	1	0.960	-	-
	12	11.780