Protein Alignment Klp67A and Kif3c

DIOPT Version :10

• Sequence 1: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_445938.1
• Gene: Kif3c / 85248
• RGDID: 621538
• Length: 796
• Species: Rattus norvegicus
• Alignment Length: 780
• Identity: 223/780 - (28%)
• Similarity: 354/780 - (45%)
• Gaps: 163/780 - (20%)

  Fly     9 IKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLTME 73
            :||..|.||.:.:|.......|:.:          |.:..:...:..:....::.|      |..
  Rat    11 LKVVARCRPLSRKEEAAGHEQILTM----------DVKLGQVTLRNPRAAPGELPK------TFT 59

  Fly    74 FDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHP---GLTYLTM 135
            ||.|:|..:...||::|...||:|:||.|:|.:||.||.||.|||:||.|:...|   |:.....
  Rat    60 FDAVYDASSKQADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQGTWVEPELRGVIPNAF 124

  Fly   136 QDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGP---LKLRED-NNGVVVSGLCLTPIYS 196
            :.:|..| ::|..:::.|..||||:|.|.:.:||:|. |   |:|:|: ..||.:..|......:
  Rat   125 EHIFTHI-SRSQNQQYLVRASYLEIYQEEIRDLLSKE-PGKRLELKENPETGVYIKDLSSFVTKN 187

  Fly   197 AEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTK---RTVKLSMIDLAGSER 258
            .:|:..::.|||..|....|..|..||||||||.:.:..:||.:|.:   |..||:::|||||||
  Rat   188 VKEIEHVMNLGNQARAVGSTHMNEVSSRSHAIFVITVECSERGSDGQDHIRVGKLNLVDLAGSER 252

  Fly   259 -------------AASTKG-------------IGVRFKEGASINKSLLALGNCINKLADGLK-HI 296
                         ..||.|             .|.|.||.:.||.||.||||.|..||.... ||
  Rat   253 QNKAGPNTPGGPATQSTAGGGGGGGGTSGSGSSGERPKEASKINLSLSALGNVIAALAGNRSTHI 317

  Fly   297 PYRDSNLTRILKDSLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPT 361
            |||||.|||:|:||||||.:|:|||.:..:|.:|:::.:||::|:|||.|:...:.|    :.|.
  Rat   318 PYRDSKLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVN----EDPK 378

  Fly   362 EFYVKKIDEVVAENERLKERNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHV 426
            :..:::..|.:|   |||          .|||:.|..|..|....:...|  ||.|.|...:..|
  Rat   379 DTLLREFQEEIA---RLK----------AQLEKKGMLGKRPRRKSSRRKK--AVSAPAGYPEGAV 428

  Fly   427 L--------------------GMRSKI-KNI-NYRQTLKKELEEFRKLMCVDQRVCQEDFRRFAN 469
            :                    .:.:.: ||: ||.|..|:.|||       ::...|:|
  Rat   429 IEAWVAEEEDDNNNNHRPPQPTLEAALEKNMENYLQEQKERLEE-------EKAAIQDD------ 480

  Fly   470 YMSTLTSQMEKYKEELPSWLSKMEIAYQDLESLKREVNKSKAYQILIVYVKYKDLE--LQLTKQN 532
             .|.::.:.:|..||    ..||      ||.||||   .:|.::|.  .|||.:|  |.:..:|
  Rat   481 -RSLVSEEKQKLLEE----KEKM------LEDLKRE---QQATELLA--AKYKAMESKLLIGGRN 529

  Fly   533 IFNNHVNAINQELVENLDLMRKSFRTACEVLNQTYDRLEDGQKL------TPEIEAVFERLLRKM 591
            |. :|.|    |..:.|:|.|:      |:..|.....|..|::      |.|:...:..|
  Rat   530 IM-DHTN----EQQKMLELKRQ------EIAEQKRREREMQQEMLLRDEETMELRGTYSSL---- 579

  Fly   592 RFADSEANTKMAEMNPLAVPV-ALRSSAQEEEEPTCSLTASAKKRQRQAAQSDDDLHLSMEDFDS 655
               ..|...|..::..|...: |:::..|::.|....:....::.|.:..:.....:|.:|:|..
  Rat   580 ---QQEVEVKTKKLKKLYAKLQAVKAEIQDQHEEYIRVRQDLEEAQNEQTRELKLKYLIIENFIP 641

  Fly   656 QDTES--------DSEELHRTFKR--PRNLNETQVLGPCSSSSSSSTSSSSSARKALTATVTKPR 710
            .:.::        |.||....|:.  |..:|.:|:....:|:.......|..||.|: |..:.||
  Rat   642 PEEKNKIMNRLFLDCEEEQWKFQPLVPAGVNNSQMKKRPTSAVGYKRPISQYARVAM-AMGSHPR 705

  Fly   711  710
              Rat   706  705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	133/373 (36%)
Kif3c	NP_445938.1	KISc_KIF3	9..367	CDD:276822	133/373 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..292		8/40 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..421		8/25 (32%)
		Smc	<452..>637	CDD:440809	53/231 (23%)
		Globular. /evidence=ECO:0000255	633..793		18/74 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..796