Protein Alignment Klp67A and kif5ab

DIOPT Version :10

• Sequence 1: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: XP_009301044.1
• Gene: kif5ab / 799274
• ZFINID: ZDB-GENE-110510-3
• Length: 1050
• Species: Danio rerio
• Alignment Length: 896
• Identity: 230/896 - (25%)
• Similarity: 375/896 - (41%)
• Gaps: 214/896 - (23%)

  Fly     8 NIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPD-EEDDEFFFQGAKQPYRDITKRMNKKLT 71
            ||:|..|.||.|..|:.:..:            |.|. :.||.....|.               :
Zfish     9 NIRVLCRFRPLNQSEILRGDK------------FMPTFQGDDTVIIAGR---------------S 46

  Fly    72 MEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHP----GLTY 132
            ..||:||..:.:.:.::..|...:|..||:|||.::|.||.|.:|||:||.| :.|.    |:..
Zfish    47 YVFDKVFPTNCTQEQVYNTCAQQIVKDVLDGYNGTIFAYGQTSSGKTYTMEG-KLHDANGRGIIP 110

  Fly   133 LTMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLL--TKSGPLKLREDNNGV-VVSGLCLTPI 194
            ...:|:|:.|....:..:|.:.|||.|:|.:.:.:||  ||:. |.:.||.|.| .|.|.....:
Zfish   111 RIAEDIFNHIYTMDENLEFHIKVSYFEIYMDKIRDLLDVTKTN-LSVHEDKNRVPYVKGCTERFV 174

  Fly   195 YSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKRTVKLSMIDLAGSERA 259
            .|.||::.::..|.::|....|:.|..|||||:||.::|:....:|:.|...||.::||||||:.
Zfish   175 SSPEEVMDLIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQEHVETEQKLCGKLYLVDLAGSEKV 239

  Fly   260 ASTKGIGVRFKEGASINKSLLALGNCINKLADGLK-HIPYRDSNLTRILKDSLGGNCRTLMVANV 323
            :.|...|....|..:|||||.||||.|:.||:|.| |:|||||.:||||:|||||||||.|....
Zfish   240 SKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTMFICC 304

  Fly   324 SMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKIDEVVAENERLKERNKALEAK 388
            |.|:....:|.:||.:..|||.|..:...|:   ::..|.:.:|.::...:|:.|||..:.|||
Zfish   305 SPSAYNDAETKSTLMFGQRAKTIMNSASVNL---ELTAEQWKRKYEKEKEKNKDLKESMQRLEA- 365

  Fly   389 ATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHVLGMRSKIKNINYRQT----------LK 443
                           ||..|.:....|........|..:...:.:.|.::.||          .:
Zfish   366 ---------------ELNHWRNGESVVLITPVSPAECDVTEDTAVDNQSHGQTELIPEQHNSRYE 415

  Fly   444 KELEE-FRKLMCVDQRV---CQEDFRRFANYMSTLTSQMEKYKEELPSWLSKMEIAYQDLESLKR 504
            :|::: :|:|...|..:   ||               .:||.||::......:..|..|||.::.
Zfish   416 EEIQQLYRQLDDKDDEINLQCQ---------------LVEKLKEQMLDQEELLACARADLERVQC 465

  Fly   505 EVNKSKAYQILIVYVKYKDLELQLTKQNIFNNHVNAINQELVENLDLMRKSFRTACEVLNQTYDR 569
            :|.:.:|..      :...||:|...|.:         :||..:.|  .||.        :..|.
Zfish   466 DVRRLQADS------ESSKLEVQEVLQAL---------EELALSYD--HKSL--------EAQDN 505

  Fly   570 LEDGQKLTPE----------IEAVFERL-----LRKMRFADSEANTKMAEMN---------PLAV 610
            ....::||.|          :|:.|.||     .::.|..: ..||.:.::|         .|.:
Zfish   506 SRHNRRLTEELAHTTSALLSLESDFSRLQEVNGQQRKRITE-VLNTLVKDLNDFSFILGNGDLRL 569

  Fly   611 PVALRSSAQEEEEPTCSLTASAK-------KRQRQAAQSDDDLHLSMEDFDSQ------------ 656
            |..|....:||....|...:..|       ||.||......|.|..||:...:
Zfish   570 PSELSGVLEEEYAVVCVYMSKVKSELKTLVKRCRQLESLQTDCHRKMEETGRELSSCQLLISQHE 634

  Fly   657 -DTESDSEELHRTFKRPRNLNE-----TQVLGPCSSSSS-------SSTSSSSSARKALTATVTK 708
             ...|.:|.:.....:.|.|.|     ::.|....::.|       :..|.:..:.||:......
Zfish   635 AKIRSLTEYMQNMELKKRQLEENYDCLSEELAKLQNTESILDRPLDTDESVNVKSHKAVDQKSEV 699

  Fly   709 PRTVQ--------------QRLVSDLISDQNVRGGNE----KIKKALLKSNHF------------ 743
            .|..|              |:::.:| :|.|.|...:    .::.::|||...
Zfish   700 QREPQHKQLGRLRDDINHKQKIIDEL-TDDNQRLDLQLEQLSVEFSVLKSREHEKSRQLEELRYL 763

  Fly   744 ------TAQ---GLQRTLAAA----SLAKENVKYNANYVRKSPRALMAKAL 781
                  |.|   ||:.|:.:|    .::.:|  .|..|.|.:..:|.|:.|
Zfish   764 HERQEQTRQDMKGLEETVVSAYRKYDISNDN--NNGVYDRPAHFSLKAREL 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	126/346 (36%)
kif5ab	XP_009301044.1	KISc_KHC_KIF5	7..327	CDD:276820	126/346 (36%)
		SMC_prok_B	<408..738	CDD:274008	69/371 (19%)
		EnvC	700..>921	CDD:443969	23/116 (20%)
		Khc_CBD_cc	853..922	CDD:467880