Protein Alignment Klp67A and cenpe

DIOPT Version :10

• Sequence 1: NP_523992.2
• Gene: Klp67A / 39068
• FlyBaseID: FBgn0004379
• Length: 814
• Species: Drosophila melanogaster
• Sequence 2: NP_001314688.1
• Gene: cenpe / 767754
• ZFINID: ZDB-GENE-060929-860
• Length: 2690
• Species: Danio rerio
• Alignment Length: 867
• Identity: 221/867 - (25%)
• Similarity: 370/867 - (42%)
• Gaps: 179/867 - (20%)

  Fly     5 QHTNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKK 69
            :.:.:||.|||||...||..:....:                  :.:::..||....:.:...:.
Zfish     3 EESAVKVCVRVRPLIKREASESSEPV------------------QLYWRSDKQAIHQLDEDGAQT 49

  Fly    70 LTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLTYLT 134
            .:..|||||....|...|:::...|||.:.:.|||.::|.||.|.:||||||:|||.:||:..|.
Zfish    50 KSYSFDRVFSAAESTAQLYQDIAKPLVVSAVEGYNGTIFAYGQTSSGKTFTMMGSEHNPGVIPLA 114

  Fly   135 MQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLT---KSGPLKLREDN-NGVVVSGLCLTPIY 195
            |.|:|..|:: ...::|.:.|||:|:|||.|.:||.   |..||::||.| ..|.|:.|....:.
Zfish   115 MADVFKTIKS-FPKKEFLLRVSYMEIYNETVTDLLCDSWKRKPLEIREGNYKNVYVADLTEELVT 178

  Fly   196 SAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITERKTDTKR--------TVKLSMID 252
            |.|:.|..:..|..:|....|..|..|||||.||::.:...||...|..        ...|:::|
Zfish   179 SPEQALSWITKGEKNRHYGKTKMNQRSSRSHTIFRMILESRERSDPTAGESADGAIIVSHLNLVD 243

  Fly   253 LAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLADGLK--HIPYRDSNLTRILKDSLGGNC 315
            |||:|||:.|...|.|||||.:||:||..||..|.||:|..:  .:.||||.|||||::|||||.
Zfish   244 LAGAERASQTGAEGARFKEGCNINRSLFTLGQVIKKLSDESQKGFLNYRDSKLTRILQNSLGGNA 308

  Fly   316 RTLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSKMPTEFYVKKI-----------D 369
            :|:::..::.:  |.::|.:||::||.||             :|..:.:|.::           :
Zfish   309 KTVIICTITPA--TVDETVSTLQFASAAK-------------RMKNDPHVTEVSDEGALLRRYRN 358

  Fly   370 EVVAENERLKERNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHVLGMRSKIK 434
            |:|....||:|.:...:..||:.|                 .:..:.....|||..   ...:||
Zfish   359 EIVDLKRRLQEVSSVTQTTATERE-----------------SLCQLLQEKDQLQRE---QEDRIK 403

  Fly   435 NI-----------------NYRQTLKKELEEFRKLMCVDQRVCQEDF---------RRFANYMST 473
            |:                 ..|.|...:|  .|....:::.:|..|.         ||....::.
Zfish   404 NLTKLLVTSSNIALIPKVPKRRVTWGGKL--LRSAHLLNEDLCSTDMSFAEPYLKKRRADCSLAD 466

  Fly   474 LTSQMEKYKEELPSWLSKMEIAYQDLESLKREVNKS----------KAYQILIVYVKYKDLELQL 528
            :...|:::.....  .:.||....|:|.....|..|          :|.:::   .|...||.||
Zfish   467 VGEDMDEFDSRFD--FTAMEEPNMDMEMSSITVRSSSEGSHFLDSPRASELM---QKVSSLESQL 526

  Fly   529 TKQNIFNNHVNAINQELVENLDLMRKSFRTACEVLNQTYDRLEDGQKLTPEIEAVFERLLRKMRF 593
            ..:.........:|.||...|..::.....      |:....|:...:: |:|...|.|.|::..
Zfish   527 EAETQSKQIAEEMNAELQMKLSHLQNMLEA------QSAPSHEEKNTIS-ELEKQMEDLQRRLET 584

  Fly   594 ADSEANTKMAEMNPLAVPVALRSSAQEEEEPTCSLTASAKKRQRQAAQSDDDLHLSMEDFDSQDT 658
            ...|..|...:...|.:.||      |.|:|                 |::.||       ||:|
Zfish   585 EVQERQTAEEKSISLELKVA------ELEKP-----------------SEELLH-------SQNT 619

  Fly   659 ----ESDSEELHR-----TFKRPRNLNETQVLGPCSSSSSSSTSSSSSARKALTATVTKPRTVQQ 714
                :.|.||..:     :|::...:.|..::    ..|...|:....:.||...::.|.:...|
Zfish   620 CERVKKDLEEAIQLCETVSFEKDAVIAERDMI----KHSLDMTTEELESLKAEKDSLQKEKDALQ 680

  Fly   715 RLVSDLISDQNVRGGNEKIKKALLKSNHFTAQGLQRTLAAA-SLAKENVKYNANYVR--KSPRAL 776
            :....|..|...|...::.:|...:|.    :..:|.|.|. |..::|:|.:.:.::  |:..||
Zfish   681 KDKDALQKDMEERRDADEFEKLEEESK----RDYERELEAENSRLEKNLKQSEDMIQKLKADLAL 741

  Fly   777 MAKALAGTSTLARKPLGSASKE 798
            |:..|...:.|..:..|.:.|:
Zfish   742 MSSELQKKTDLTTELQGFSGKD 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp67A	NP_523992.2	KISc_KIP3_like	8..346	CDD:276821	129/351 (37%)
cenpe	NP_001314688.1	KISc_CENP_E	6..337	CDD:276825	129/364 (35%)
		SMC_prok_B	512..1266	CDD:274008	61/300 (20%)
		SMC_prok_B	<917..1759	CDD:274008
		Smc	<1486..>2047	CDD:440809
		sbcc	1716..2415	CDD:129705